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Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells
Keitany GJ, et al.
Cell Chemical Biology
December 2023
Authors and Affiliates
Gladys J Keitany 1, Benjamin E R Rubin 1, Meghan E Garrett 1, Andrea Musa 1, Jeff Tracy 1, Yu Liang 1, Peter Ebert 1, Amanda J Moore 1, Jonathan Guan 1, Erica Eggers 1, Ninnia Lescano 1, Ryan Brown 1, Adria Carbo 1, Hussein Al-Asadi 1, Travers Ching 1, Austin Day 1, Rebecca Harris 1, Charles Linkem 1, Dimitry Popov 1, Courtney Wilkins 1, Lianqu Li 2, Jiao Wang 2, Chuanxin Liu 2, Li Chen 2, Jennifer N Dines 1, Caroline Atyeo 3, Galit Alter 3, Lance Baldo 1, Anna Sherwood 1, Bryan Howie 1, Mark Klinger 1, Erik Yusko 1, Harlan S Robins 1, Sharon Benzeno 1, Amy E Gilbert 4;
1 Adaptive Biotechnologies, Seattle, WA 98109, USA.
2 GenScript ProBio Biotech, Nanjing, Jiangsu Province, China.
3 Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
4 Adaptive Biotechnologies, Seattle, WA 98109, USA. Electronic address: agilbert@adaptivebiotech.com.
Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides
Yu Z, et al.
Journal of Investigative Dermatology
December 2023
Authors and Affiliates
Zizi Yu 1, Pablo Vieyra-Garcia 2, Theresa Benezeder 2, Jack D Crouch 1, Ira R Kim 1, John T O'Malley 1, Phillip M Devlin 3, Ahmed Gehad 1, Qian Zhan 1, Johann E Gudjonsson 4, Mrinal K Sarkar 4, J Michelle Kahlenberg 5, Nega Gerard 1, Jessica E Teague 1, Thomas S Kupper 6, Nicole R LeBoeuf 6, Cecilia Larocca 6, Marianne Tawa 7, Bohdan Pomahac 8, Simon G Talbot 9, Dennis P Orgill 9, Peter Wolf 10, Rachael A Clark 11;
1 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2 Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
3 Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
4 Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
5 Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
6 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Center for Cutaneous Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
7 Center for Cutaneous Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
8 Division of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA.
9 Division of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
10 Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. Electronic address: peter.wolf@medunigraz.at.
11 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: rclark@bwh.harvard.edu.
Ibrutinib maintenance after frontline treatment in patients with mantle cell lymphoma.
Karmali R, et al.
Blood Advances
December 2023
Authors and Affiliates
Reem Karmali, Jeremy S Abramson, Deborah M Stephens, Jeffrey Barnes, Jane N Winter, Shuo Ma, Juehua Gao, Jason Kaplan, Adam M Petrich, Ephraim Hochberg, Tak Takvorian, Xinlei Mi, Valerie Nelson, Leo I Gordon, Barbara Pro
Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.
Sonneveld P, et al.
New England Journal of Medicine
December 2023
Authors and Affiliates
Pieter Sonneveld, Meletios A Dimopoulos, Mario Boccadoro, Hang Quach, P Joy Ho, Meral Beksac, Cyrille Hulin, Elisabetta Antonioli, Xavier Leleu, Silvia Mangiacavalli, Aurore Perrot, Michele Cavo, Angelo Belotti, Annemiek Broijl, Francesca Gay, Roberto Mina, Inger S Nijhof, Niels W C J van de Donk, Eirini Katodritou, Fredrik Schjesvold, Anna Sureda Balari, Laura Rosiñol, Michel Delforge, Wilfried Roeloffzen, Tobias Silzle, Annette Vangsted, Hermann Einsele, Andrew Spencer, Roman Hajek, Artur Jurczyszyn, Sarah Lonergan, Tahamtan Ahmadi, Yanfang Liu, Jianping Wang, Diego Vieyra, Emilie M J van Brummelen, Veronique Vanquickelberghe, Anna Sitthi-Amorn, Carla J de Boer, Robin Carson, Paula Rodriguez-Otero, Joan Bladé, Philippe Moreau; PERSEUS Trial Investigators
The prospect of universal coronavirus immunity: characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses
Soni MK, et al.
Frontiers in Immunology
November 2023
Authors and Affiliates
Mithil K Soni 1, Edoardo Migliori 1, Jianing Fu 1, Amer Assal 2 3, Hei Ton Chan 3, Jian Pan 3, Prabesh Khatiwada 1, Rodica Ciubotariu 3, Michael S May 3, Marcus R Pereira 4, Valeria De Giorgi 5, Megan Sykes 1, Markus Y Mapara 1, Pawel J Muranski 1;
1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, United States.
2 Department of Medicine, Blood and Marrow Transplantation and Cell Therapy Program, Columbia University Irving Medical Center, New York, NY, United States.
3 Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, New York, NY, United States.
4 Department of Medicine, Division of Infectious Disease, Columbia University College of Physicians and Surgeons, New York, NY, United States.
5 Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, United States.
Elucidating the heterogeneity of immunotherapy response and immune-related toxicities by longitudinal ctDNA and immune cell compartment tracking in lung cancer
Murray JC, et al.
Clinical Cancer Research
November 2023
Authors and Affiliates
Joseph C Murray 1, Lavanya Sivapalan 2, Karlijn Hummelink 3, Archana Balan 2, James R White 4, Noushin Niknafs 5, Lamia Rhymee 2, Gavin Pereira 2, Nisha Rao 2, Benny Weksler 6, Nathan Bahary 6, Jillian Phallen 2, Alessandro Leal 7, David L Bartlett 8, Kristen A Marrone 5, Jarushka Naidoo 9, Akul Goel 10, Benjamin Levy 11, Samuel Rosner 2, Christine L Hann 2, Susan C Scott 2, Josephine Feliciano 12, Vincent K Lam 13, David S Ettinger 5, Qing Kay Li 2, Peter B Illei 14, Kim Monkhorst 15, Robert B Scharpf 9, Julie R Brahmer 2, Victor E Velculescu 2, Ali H Zaidi 6, Patrick M Forde 2, Valsamo Anagnostou 2;
1Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, United States.
2Johns Hopkins University School of Medicine, Baltimore, MD, United States.
3Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.
4Resphera Biosciences, Baltimore, MD, United States.
5Johns Hopkins University, Baltimore, MD, United States.
6Allegheny Health Network, Pittsburgh, PA, United States.
7Delfi Diagnostics, Baltimore, Maryland, United States.
8University of Pittsburgh, Pittsburgh, PA, United States.
9Johns Hopkins University School of Medicine, Baltimore, United States.
10California Institute of Technology, United States.
11Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Washington, D.C., United States.
12Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, MD, United States.
13Johns Hopkins, Baltimore, MD, United States.
14Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
15Netherlands Cancer Institute, Amsterdam, Netherlands.
Characterization of immune cell populations of cutaneous neurofibromas in neurofibromatosis 1
Kallionpää RA, et al.
November 2023
Authors and Affiliates
Roope A Kallionpää 1, Sirkku Peltonen 2, Kim My Le 3, Eija Martikkala 3, Mira Jääskeläinen 3, Elnaz Fazeli 4, Pilvi Riihilä 5, Pekka Haapaniemi 6, Anne Rokka 6, Marko Salmi 7, Ilmo Leivo 3, Juha Peltonen 8;
1 Institute of Biomedicine, University of Turku, Turku, Finland; FICAN West Cancer Centre, University of Turku and Turku University Hospital, Turku, Finland.
2 Department of Dermatology and Venereology, University of Turku, Turku, Finland; Department of Dermatology, Turku University Hospital, Turku, Finland; Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Dermatology and Venereology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Dermatology and Allergology, University of Helsinki, Helsinki, Finland; Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
3 Institute of Biomedicine, University of Turku, Turku, Finland.
4 Institute of Biomedicine, University of Turku, Turku, Finland; Biomedicum Imaging Unit, Faculty of Medicine and HiLIFE, University of Helsinki, Helsinki, Finland.
5 Department of Dermatology and Venereology, University of Turku, Turku, Finland; Department of Dermatology, Turku University Hospital, Turku, Finland; FICAN West Cancer Research Laboratory, University of Turku and Turku University Hospital, Turku, Finland.
6 Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
7 Institute of Biomedicine, University of Turku, Turku, Finland; MediCity Research Laboratory, and InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
8 Institute of Biomedicine, University of Turku, Turku, Finland; FICAN West Cancer Centre, University of Turku and Turku University Hospital, Turku, Finland. Electronic address: juhpel@utu.fi.
The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis
Norberg SM, et al.
Science Translational Medicine
November 2023
Authors and Affiliates
Scott M Norberg 1, Ke Bai 2, Cem Sievers 2, Yvette Robbins 2, Jay Friedman 2, Xinping Yang 2, Meg Kenyon 1, Elizabeth Ward 3, Jeffrey Schlom 1, James Gulley 1, Amy Lankford 3, Roshanak Semnani 3, Helen Sabzevari 3, Douglas E Brough 3, Clint T Allen 1,2;
1 Center for Immune-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
2 Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
3 Precigen Inc., Germantown, MD 20876, USA.
Heterozygote advantage at HLA class I and II loci and reduced risk of colorectal cancer
Tsai Y, et al.
Frontiers in Immunology
November 2023
Authors and Affiliates
Ya-Yu Tsai 1, Chenxu Qu 2, Joseph D Bonner 3, Rebeca Sanz-Pamplona 4 5 6 7, Sidney S Lindsey 3, Marilena Melas 8, Kevin J McDonnell 3, Gregory E Idos 3, Christopher P Walker 3, Kevin K Tsang 3, Diane M Da Silva 2, Ferran Moratalla-Navarro 4 5 6 9, Asaf Maoz 10, Hedy S Rennert 11, W Martin Kast 2, Joel K Greenson 12, Victor Moreno 4 5 6 9, Gad Rennert 11, Stephen B Gruber 3, Stephanie L Schmit 1 13;
1Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, United States.
2Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States.
3Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, United States.
4Catalan Institute of Oncology (ICO), Hospitalet de Llobregat, Barcelona, Spain.
5ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.
6Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
7Hospital Universitario Lozano Blesa, Aragon Health Research Institute (IISA), ARAID Foundation, Aragon Government, Zaragoza, Spain.
8Molecular Diagnostics, New York Genome Center, New York, NY, United States.
9Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona, Barcelona, Spain.
10Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, United States.
11B. Rappaport Faculty of Medicine, Technion and the Association for Promotion of Research in Precision Medicine (APRPM), Haifa, Israel.
12Department of Pathology, University of Michigan, Ann Arbor, MI, United States.
13Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, OH, United States.