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Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Ruella et al.
Nature Medicine
October 2018
Authors and Affiliates
Ruella M1,2,3,4,5, Xu J1,2,3, Barrett DM6, Fraietta JA1,2,3,4, Reich TJ1, Ambrose DE1, Klichinsky M1,7, Shestova O1, Patel PR1, Kulikovskaya I1, Nazimuddin F1, Bhoj VG1,2,3, Orlando EJ8, Fry TJ9, Bitter H8, Maude SL6, Levine BL1,2,3, Nobles CL10, Bushman FD10, Young RM1, Scholler J1, Gill SI1,3,5, June CH11,12,13,14, Grupp SA6, Lacey SF1,2,3, Melenhorst JJ15,16,17.
1Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
2
Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
3
Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
4
Parker Institute for Cellular Immunotherapy at the University of Pennsylvania, Philadelphia, PA, USA.
5
Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
6
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
7
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
8
Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
9
University of Colorado, Children's Hospital Colorado, Denver, CO, USA.
10
Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
11
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.
12
Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.
13
Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.
14
Parker Institute for Cellular Immunotherapy at the University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.
15
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. mej@upenn.edu.
16
Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. mej@upenn.edu.
17
Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. mej@upenn.edu
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma
Amaria et al.
Nature Medicine
Papers
October 2018
Authors and Affiliates
Rodabe N. Amaria1, Sangeetha M. Reddy2, Hussein A. Tawbi1, Michael A. Davies1, Merrick I. Ross3, Isabella C. Glitza1, Janice N. Cormier3, Carol Lewis4, Wen-Jen Hwu1, Ehab Hanna4, Adi Diab1, Michael K. Wong1, Richard Royal3, Neil Gross4, Randal Weber4, Stephen Y. Lai4, Richard Ehlers3, Jorge Blando5, Denái R. Milton6, Scott Woodman1, Robin Kageyama7, Danny K. Wells7, Patrick Hwu1, Sapna P. Patel1, Anthony Lucci3, Amy Hessel4, Jeffrey E. Lee3, Jeffrey Gershenwald3, Lauren Simpson1, Elizabeth M. Burton3, Liberty Posada1, Lauren Haydu3, Linghua Wang8, Shaojun Zhang8, Alexander J. Lazar 9, Courtney W. Hudgens 9, Vancheswaran Gopalakrishnan3, Alexandre Reuben3, Miles C. Andrews3, Christine N. Spencer8, Victor Prieto9, Padmanee Sharma5,10, James Allison5, Michael T. Tetzlaff9,11 and Jennifer A. Wargo3,8
1Department of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA. 2Department of Breast Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA. 3Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA. 4Department of Head and Neck Surgery, MD Anderson Cancer Center, Houston, TX, USA. 5Department of Immunology, MD Anderson Cancer Center, Houston, TX, USA. 6Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA. 7Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. 8Department of Genomic Medicine, MD Anderson Cancer Center, Houston, TX, USA. 9Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA. 10Department of Genitourinary Cancers, MD Anderson Cancer Center, Houston, TX, USA. 11Department of Translational and Molecular Pathology, MD Anderson Cancer Center, Houston, TX, USA.
CD4+T cells mediate protection against Zika associated severe disease in a mouse model of infection
Hassert et al.
Papers
PLOS Pathogens
September 2018
Authors and Affiliates
Mariah Hassert1, Kyle J. Wolf1, Katherine E. Schwetye2, Richard J. DiPaolo1, James D. Brien1, Amelia K. Pinto1
1Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, Missouri, United States of America, 2Department of Pathology, Saint Louis University, St. Louis, Missouri, United States of America
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
Paulson et al.
Nature Communications
Papers
September 2018
Authors and Affiliates
K.G. Paulson1,2,3, V. Voillet2, M.S. McAfee2, D.S. Hunter2, F.D. Wagener2, M. Perdicchio2,6, W.J. Valente2, S.J. Koelle1,2, C.D. Church1, N. Vandeven1, H. Thomas1, A.G. Colunga1, J.G. Iyer1, C. Yee4, R. Kulikauskas1, D.M. Koelle1,2,5, R.H. Pierce2, J.H. Bielas1,2, P.D. Greenberg1,2, S. Bhatia1,2,3, R. Gottardo1,2, P. Nghiem1,2,3 & A.G. Chapuis1,2,3
1University of Washington, Seattle, WA, USA. 2Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 3Seattle Cancer Care Alliance, Seattle, WA, USA. 4MD Anderson Cancer Center, Houston, TX, USA. 5Benaroya Research Institute, Seattle, WA, USA.
Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis
Jelcic et al.
Papers
September 2018
Authors and Affiliates
Ivan Jelcic,1 Faiez Al Nimer,1,2 Jian Wang,1 Verena Lentsch,1 Raquel Planas,1 Ilijas Jelcic,1 Aleksandar Madjovski,1 Sabrina Ruhrmann,2 Wolfgang Faigle,1 Katrin Frauenknecht,3 Clemencia Pinilla,4 Radleigh Santos,5 Christian Hammer,6,7 Yaneth Ortiz,1 Lennart Opitz,8 Hans Gronlund,9 Gerhard Rogler,10 Onur Boyman,11 Richard Reynolds,12 Andreas Lutterotti,1 Mohsen Khademi,2 Tomas Olsson,2 Fredrik Piehl,2 Mireia Sospedra,1 and Roland Martin1
1Neuroimmunology and MS Research Section (NIMS), Neurology Clinic, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland 2Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, 17176 Stockholm, Sweden 3Institute of Neuropathology, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland 4Torrey Pines Institute for Molecular Studies (TPIMS), San Diego, CA, USA 5Torrey Pines Institute for Molecular Studies (TPIMS), Port St. Lucie, FL, USA 6School of Life Sciences, E cole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland 7Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland 8Functional Genomics Center Zurich, Swiss Federal Institute of Technology and University of Zurich, 8057 Zurich, Switzerland 9Therapeutic Immune Design Unit, Department of Clinical Neuroscience, Karolinska Institutet, 17176 Stockholm, Sweden 10Department of Gastroenterology and Hepatology, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland 11Department of Immunology, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland 12Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
T cells in patients with narcolepsy target self-antigens of hypocretin neurons
Latorre et al.
Nature
Papers
September 2018
Authors and Affiliates
Latorre D1,2, Kallweit U3,4, Armentani E1, Foglierini M1,5, Mele F1, Cassotta A1,2, Jovic S1, Jarrossay D1, Mathis J3, Zellini F6, Becher B7, Lanzavecchia A1, Khatami R8, Manconi M3,6, Tafti M9, Bassetti CL10, Sallusto F11,12
1Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland. 2Institute of Microbiology, ETH Zurich, Zurich, Switzerland. 3Department of Neurology, University Hospital, Bern, Switzerland. 4Institute of Immunology, University of Witten/Herdecke, Witten, Germany. 5Swiss Institute of Bioinformatics, Lausanne, Switzerland. 6Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Lugano, Switzerland. 7Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. 8Center for Sleep Research and Sleep Medicine, Clinic Barmelweid, Barmelweid, Switzerland. 9Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. 10Department of Neurology, University Hospital, Bern, Switzerland. 11Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland. 12Institute of Microbiology, ETH Zurich, Zurich, Switzerland.
Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus
Clave et al.
Science Translational Medicine
September 2018
Authors and Affiliates
Clave E1,2, Araujo IL1,2, Alanio C3,4,5, Patin E6,7,8, Bergstedt J9, Urrutia A3,4,5,10, Lopez-Lastra S5,11, Li Y5,11, Charbit B3, MacPherson CR3, Hasan M3, Melo-Lima BL1,2, Douay C1,2, Saut N12,13, Germain M14,15, Trégouët DA14,15, Morange PE12,13, Fontes M10,16, Duffy D3,4,5, Di Santo JP5,11, Quintana-Murci L6,7,8, Albert ML17,4,5,10, Toubert A18,2,19; Milieu Intérieur Consortium.
Author information
1
Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, 75010 Paris, France.
2
INSERM, UMRS-1160, Alloimmunity-Autoimmunity-Transplantation, 75010 Paris, France.
3
Center for Translational Research, Technology Core, Institut Pasteur, 75015 Paris, France.
4
Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 75015 Paris, France.
5
INSERM, UMRS-1223, 75015 Paris, France.
6
Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France.
7
CNRS UMR-2000, 75015 Paris, France.
8
Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, 75015 Paris, France.
9
Department of Automatic Control, Lund University, Lund SE-221, Sweden.
10
Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
11
Innate Immunity Unit, Institut Pasteur, 75015 Paris, France.
12
Laboratory of Haematology, La Timone Hospital, 13005 Marseille, France.
13
Aix Marseille University, INSERM, UMRS-1260, INRA U1260, Center for Cardiovascular and Nutrition Research (C2VN), 13005 Marseille, France.
14
Sorbonne Université, Université Paris 6/UPMC, INSERM, UMRS-1166, Genomics and Pathophysiology of Cardiovascular Diseases, 75013 Paris, France.
15
Institute for Cardiometabolism and Nutrition, 75013 Paris, France.
16
International Group for Data Analysis, Institut Pasteur, 75015 Paris, France.
17
Center for Translational Research, Technology Core, Institut Pasteur, 75015 Paris, France. antoine.toubert@univ-paris-diderot.fr albert.matthew@gene.com.
18
Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, 75010 Paris, France. antoine.toubert@univ-paris-diderot.fr albert.matthew@gene.com.
19
Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint-Louis, AP-HP, 75010 Paris, France.
Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease
Chung et al.
Hepatology Communications
Papers
August 2018
Authors and Affiliates
Brian K. Chung,1-4 Eva Kristine Klemsdal Henriksen,2-5 Kristin Kaasen Jørgensen,2,6 Tom H. Karlsen,2-5 Gideon M. Hirschfield,1,7 and Evaggelia Liaskou1
1Centre for Liver Research and National Institute for Health Research Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; 2Norwegian PSC Research Center, Depart- ment of Transplantation Medicine, Division of Surgery, Inflammatory Medicine, and Transplantation, Oslo University Hospital Rikshospi- talet, Oslo, Norway; 3Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 4Research Institute of Internal Medicine, Division of Surgery, Inflammatory Medicine, and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 5K.G. Jebsen Inflammation Research Center, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 6Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; 7Centre for Rare Diseases, Institute of Translational Medicine, Birmingham Health Partners, University Hospitals Birmingham, Birmingham, United Kingdom.
Quantifying size and diversity of the human T cell alloresponse
DeWolf et al.
JCI Insight
Papers
August 2018
Authors and Affiliates
Susan DeWolf,1 Boris Grinshpun,2 Thomas Savage,1 Sai Ping Lau,1 Aleksandar Obradovic,1 Brittany Shonts,1 Suxiao Yang,1 Heather Morris,1 Julien Zuber,1 Robert Winchester,3 Megan Sykes,1 and Yufeng Shen4
1Center for Translational Immunology, Department of Medicine, 2Department of Systems Biology, 3Division of Rheumatology, Department of Medicine, and 4Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, New York, USA.