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Early expansion of donor-specific Tregs in tolerant kidney transplant recipients

Savage et al.
JCI Insight
November 2018
Authors and Affiliates
Savage TM1, Shonts BA1, Obradovic A1, Dewolf S1, Lau S1, Zuber J1, Simpson MT1, Berglund E1, Fu J1, Yang S1, Ho SH1, Tang Q2, Turka LA3,4, Shen Y5, Sykes M1,6,7 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, New York, USA. 2 Department of Surgery, University of California San Francisco, San Francisco, California, USA. 3 Center for Translational Sciences, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA. 4 Immune Tolerance Network, Bethesda, Maryland, USA. 5 Center for Computational Biology and Bioinformatics, Department of Systems Biology, Columbia University, New York, New York, USA. 6 Department of Microbiology & Immunology, Columbia University Medical Center, Columbia University, New York, New York, USA. 7 Department of Surgery, Columbia University Medical Center, Columbia University, New York, New York, USA.

A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus

Chen et al.
Cancer Reports
November 2018
Authors and Affiliates
Chen S1, Luperchio TR2, Wong X2, Doan EB1, Byrd AT1, Roy Choudhury K3, Reddy KL2, Krangel MS4. 1 Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. 2 Department of Biological Chemistry, Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, USA. 3 Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA. 4 Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: krang001@mc.duke.edu.

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients

Naing et al.
Cancer Cell
November 2018
Authors and Affiliates
Naing A1, Infante JR2, Papadopoulos KP3, Chan IH4, Shen C5, Ratti NP4, Rojo B4, Autio KA5, Wong DJ6, Patel MR7, Ott PA8, Falchook GS9, Pant S10, Hung A4, Pekarek KL4, Wu V4, Adamow M5, McCauley S4, Mumm JB4, Wong P5, Van Vlasselaer P4, Leveque J4, Tannir NM1, Oft M11. 1 MD Anderson Cancer Center, Houston, TX, USA. 2 Sarah Cannon Research Institute / Tennessee Oncology, PLLC, Nashville, TN, USA. 3 START Center for Cancer Care, San Antonio, TX, USA. 4ARMO BioSciences, Eli Lilly and Company, Redwood City, CA, USA. 5Memorial Sloan Kettering Cancer Center, New York, NY, USA. 6 University of California Los Angeles (UCLA), Los Angeles, CA, USA. 7 Sarah Cannon Research Institute/Florida Cancer Specialists, Sarasota, FL, USA. 8 Dana-Farber Cancer Institute, Boston, MA, USA. 9 Sarah Cannon Research Institute at HealthONE, Denver, CO, USA. 10 Oklahoma University, Oklahoma City, OK, USA. 11 ARMO BioSciences, Eli Lilly and Company, Redwood City, CA, USA. Electronic address: martinoft@gmail.com.

Resident Memory and Recirculating Memory T Cells Cooperate to Maintain Disease in a Mouse Model of Vitiligo

Richmond et al.
Journal of Investigative Dermatology
November 2018
Authors and Affiliates
Richmond JM1, Strassner JP1, Rashighi M1, Agarwal P1, Garg M1, Essien KI1, Pell LS1, Harris JE2 1 Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 2 Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. Electronic address: john.harris@umassmed.edu.

Viral genetics modulate orolabial HSV-1 shedding in humans

Ramchandani et al.
Journal of Infectious Diseases
November 2018
Authors and Affiliates
Ramchandani MS1, Jing L1, Russell RM1, Tran T1, Laing KJ1, Magaret AS2,3,4, Selke S2,3, Cheng A3, Huang ML2, Xie H2, Strachan E5, Greninger AL2, Roychoudhury P2, Jerome KR2,4, Wald A1,6,2,4, Koelle DM1,2,7,4,8 1 Department of Medicine, University of Washington, Seattle, USA. 2 Department of Laboratory Medicine, University of Washington, Seattle, USA. 3 Department of Biostatistics, University of Washington, Seattle, USA. 4 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, USA. 5 Department of Psychiatry, University of Washington, Seattle, USA. 6 Department of Epidemiology, University of Washington, Seattle, USA. 7 Global Health, University of Washington, Seattle, USA. 8 Benaroya Research Institute, Seattle, USA.

Neoadjuvant ipilimumab (3 mg/kg or 10 mg/kg) and high dose IFN-α2b in locally/regionally advanced melanoma: safety, efficacy and impact on T-cell repertoire

Tarhini et al.
Journal for ImmunoTherapy of Cancer
October 2018
Authors and Affiliates
Tarhini A1,2, Lin Y3, Lin H3, Rahman Z3, Vallabhaneni P3, Mendiratta P4, Pingpank JF3, Holtzman MP3, Yusko EC5, Rytlewski JA5, Rao UNM3, Ferris RL3, Kirkwood JM3 1 UPMC Hillman Cancer Center, Pittsburgh, USA. tarhina1@ccf.org. 2 Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute and Case Comprehensive Cancer Center, 9500 Euclid Ave CA6-157, Cleveland, OH, 44195, USA. tarhina1@ccf.org. 3 UPMC Hillman Cancer Center, Pittsburgh, USA. 4 Department of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute and Case Comprehensive Cancer Center, 9500 Euclid Ave CA6-157, Cleveland, OH, 44195, USA. 5 Adaptive Biotechnologies, Seattle, USA.

T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Ettinger et al.
Blood
Papers
October 2018
Authors and Affiliates
Ruth A. Ettinger,1 Pedro Paz,2 Eddie A. James,3 Devi Gunasekera,1,4 Fred Aswad,2 Arthur R. Thompson,1,5 Dana C. Matthews,6,7 and Kathleen P. Pratt1,4,5 1 Bloodworks Northwest Research Institute, Seattle, WA; 2 Bayer Healthcare, South San Francisco, CA; 3 Benaroya Research Institute, Seattle, WA; 4 Uniformed Services University of the Health Sciences, Bethesda, MD; 5 Division of Hematology, Department Medicine, and 6 Pediatric Hematology/ Oncology, University of Washington, Seattle, WA; and 7 Blood Disorders Program, Seattle Children’s Hospital, Seattle, WA

Neoantigenic Potential of Complex Chromosomal Rearrangements in Mesothelioma

Mansfield et al.
Journal of Thoracic Oncology
October 2018
Authors and Affiliates
Mansfield AS1, Peikert T2, Smadbeck JB3, Udell JBM4, Garcia-Rivera E5, Elsbernd L6, Erskine CL6, Van Keulen VP6, Kosari F3, Murphy SJ3, Ren H7, Serla VV3, Schaefer Klein JL3, Karagouga G3, Harris FR3, Sosa C3, Johnson SH3, Nevala W6, Markovic SN1, Bungum AO2, Edell ES2, Dong H8, Cheville JC7, Aubry MC7, Jen J9, Vasmatzis G10 1 Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota. 2 Division of Pulmonary Medicine and Critical Care, Mayo Clinic, Rochester, Minnesota. 3 Center for Individualized Medicine, Biomarker Discovery Group, Mayo Clinic, Rochester, Minnesota. 4 Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota. 5 nference, Cambridge, Massachusetts. 6 Department of Immunology, Mayo Clinic, Rochester, Minnesota. 7 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. 8 Department of Immunology, Mayo Clinic, Rochester, Minnesota; Department of Urology, Mayo Clinic, Rochester, Minnesota. 9 Medical Genome Facility, Mayo Clinic, Rochester, Minnesota. 10 Center for Individualized Medicine, Biomarker Discovery Group, Mayo Clinic, Rochester, Minnesota. Electronic address: vasmatzis.george@mayo.edu

High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata

De Jong et al.
JCI Insight
October 2018
Authors and Affiliates
de Jong A1, Jabbari A1, Dai Z1, Xing L2, Lee D1, Li MM1, Duvic M3, Hordinsky M4, Norris DA5, Price V6, Mackay-Wiggan J1, Clynes R1, Christiano AM1,7 1 Department of Dermatology and. 2 Department of Pathology, Columbia University, New York, New York, USA. 3 Department of Dermatology, MD Anderson Cancer Center, Houston, Texas, USA. 4 Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA. 5 Department of Dermatology, University of Colorado, Denver, Colorado, USA. 6 Department of Dermatology, UCSF, San Francisco, California, USA. 7 Department of Genetics and Development, Columbia University, New York, New York, USA.
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