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Preliminary analysis of spatial-temporal homogeneity and heterogeneity of TCR β chain CDR3 repertoires in BALB/c mice

Li et al.
International Journal of Molecular Epidemiology and Genetics
February 2019
Authors and Affiliates
Yuehong Li,1,* Long Ma,1,* Xiaoheng Dong,1,* Yurong Pan,1 Bin Shi,2 Xiaoyan He,1 Teng Zhang,1 Suhong Sun,3 and Xinsheng Yao1 1 Department of Immunology, Research Center for Medicine and Biology, Innovation and Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563003, China, 2 Department of Laboratory Medicine, Zunyi Medical University, Zunyi 563003, China, 3 Department of Breast Surgery, The First Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China,

T cell clonal expansions in ileal Crohn’s disease are associated with smoking behaviour and postoperative recurrence

Allez et al.
Gut
February 2019
Authors and Affiliates
Allez M1,2, Auzolle C1, Ngollo M2, Bottois H2, Chardiny V2, Corraliza AM3, Salas A3, Perez K2, Stefanescu C4, Nancey S5, Buisson A6, Pariente B7, Fumery M8, Sokol H9, Tréton X10, Barnich N11, Seksik P9, Le Bourhis L2; REMIND Study Group; Author information 1 Department of Gastroenterology, Hopital Saint Louis, Paris, France. 2 INSERM U1160, Hôpital Saint-Louis, Paris, France. 3 Hospital Clinic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain. 4 Service de Gastroentérologie, MICI et Assistance Nutritive, Hôpital Beaujon, Clichy, France. 5 Department of Gastroenterology, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre Benite, Lyon, France. 6 Gastroenterology Department, University Hospital Estaing, Clermont-Ferrand, France. 7 Department of Gastroenterology, Hopital Claude huriez, Lille, France. 8 Hepato-Gastroenterology Department, CHU Amiens, Amiens, France. 9 Department of Gastroenterology, Hopital Saint-Antoine, Paris, Île-de-France, France. 10 Service de Gastroentérologie, MICI et Assistance Nutritive, Hopital Beaujon, Clichy, France. 11 M2iSH, UMR Inserm U1071, USC INRA 2018, Université d'Auvergne, Clermont Ferrand, France.

Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool

Fu et al.
Cell Stem Cell
February 2019
Authors and Affiliates
Fu J1, Zuber J1, Martinez M2, Shonts B1, Obradovic A1, Wang H1, Lau SP1, Xia A1, Waffarn EE1, Frangaj K1, Savage TM1, Simpson MT1, Yang S1, Guo XV3, Miron M4, Senda T5, Rogers K1, Rahman A3, Ho SH1, Shen Y6, Griesemer A5, Farber DL7, Kato T8, Sykes M9. 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA. 2 Department of Pediatrics, Columbia University, New York, NY 10032, USA. 3 Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 4 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA. 5 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 6 Center for Computational Biology and Bioinformatics, Department of Systems Biology, Columbia University, New York, NY 10032, USA. 7 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 8 Department of Surgery, Columbia University, New York, NY 10032, USA. 9 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. Electronic address: megan.sykes@columbia.edu.

High frequency of shared clonotypes in human B cell receptor repertoires

Soto et al.
Nature
February 2019
Authors and Affiliates
Soto C1,2, Bombardi RG1, Branchizio A1, Kose N1, Matta P1, Sevy AM3, Sinkovits RS4, Gilchuk P1, Finn JA3, Crowe JE Jr5,6,7. 1 The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. 2 Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. 3 Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA. 4 San Diego Supercomputer Center, University of California, San Diego, San Diego, CA, USA. 5 The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu. 6 Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu. 7 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu.

Altered T Cell Receptor Beta Repertoire Patterns in Pediatric Ulcerative Colitis

Werner et al.
Clinical and Experimental Immunology
January 2019
Authors and Affiliates
Werner L1,2, Nunberg MY1,2, Rechavi E2,3,4,5, Lev A2,3,4,5, Braun T1,2, Haberman Y1,2, Lahad A1,2, Shteyer E6, Schvimer M7, Somech R2,3,4,5, Weiss B1,2, Lee YN2,3,4,5, Shouval DS1,2. 1 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 3 Pediatric Department A, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 4 Immunology Service, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 5 Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 6 Juliet Keidan Institute of Pediatric Gastroenterology, Hepatology and Nutrition, Shaare Zedek Medical Center and The Hebrew University of Jerusalem, Jerusalem, Israel. 7 Institute of Pathology, Sheba Medical Center, Tel Hashomer, Israel.

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

Lindau et al.
Journal of Immunology
January 2019
Authors and Affiliates
Lindau P1,2, Mukherjee R3, Gutschow MV2, Vignali M4, Warren EH5,6, Riddell SR5,6, Makar KW7, Turtle CJ5,6, Robins HS8,4 1 Molecular and Cellular Biology Graduate Program, University of Washington School of Medicine, Seattle, WA 98195; plindau@uw.edu hrobins@fredhutch.org. 2 Herbold Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109. 3 Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101. 4 Adaptive Biotechnologies, Seattle, WA 98102. 5 Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109. 6 Department of Medicine, University of Washington, Seattle, WA 98195; and. 7 Bill and Melinda Gates Foundation, Seattle, WA 98109. 8 Herbold Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109; plindau@uw.edu hrobins@fredhutch.org.

Tumor-infiltrating human CD4 regulatory Tcells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity

Ahmadzadeh et al.
Science Immunology
January 2019
Authors and Affiliates
Ahmadzadeh M1, Pasetto A1, Jia L1, Deniger DC1, Stevanović S2, Robbins PF1, Rosenberg SA3. 1 Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA. 2 Experimental Transplantation and Immunology Branch, NCI, NIH, Bethesda, MD 20892, USA. 3 Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma

Vieyra-Garcia et al.
JCI Insight
January 2019
Authors and Affiliates
Vieyra-Garcia P1,2, Crouch JD1, O'Malley JT1, Seger EW1, Yang CH1, Teague JE1, Vromans AM1, Gehad A1, Win TS1, Yu Z3, Lowry EL1, Na JI1,4, Rook AH5, Wolf P2, Clark RA1 1 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2 Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. 3 Harvard Medical School, Boston, Massachusetts, USA. 4 Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, South Korea. 5 Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

A multifactorial model of T cell expansion and durable clinical benefit in response to a PD-L1 inhibitor

Leiserson et al.
PLOS ONE
December 2018
Authors and Affiliates
Leiserson MDM1,2, Syrgkanis V1, Gilson A1, Dudik M3, Gillett S1, Chayes J1,3, Borgs C1, Bajorin DF4,5, Rosenberg JE4, Funt S4,5, Snyder A4,6, Mackey L1; 1 Microsoft Research New England, Cambridge, MA, United States of America. 2 University of Maryland, College Park, Department of Computer Science, College Park, MD, United States of America. 3 Microsoft Research New York, New York, NY, United States of America. 4 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America. 5 Department of Medicine, Weill Cornell Medical College, New York, NY, United States of America. 6 Adaptive Biotechnologies, Seattle, WA, United States of America