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Model to improve specificity for identification of clinically-relevant expanded T cells in peripheral blood.
Rytlewski et al.
PLOS ONE
March 2019
Authors and Affiliates
Rytlewski J1, Deng S2, Xie T2, Davis C2, Robins H1,3, Yusko E1, Bienkowska J2
1 Adaptive Biotechnologies, Seattle, Washington, United States of America.
2
Pfizer Incorporated, La Jolla, California, United States of America.
3
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation
Cippà et al.
Nature Communications
March 2019
Authors and Affiliates
Cippà PE1,2, Liu J3, Sun B4, Kumar S3, Naesens M5,6, McMahon AP7.
1
Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, 90033-9080, CA, USA. pietro.cippa@eoc.ch.
2
Division of Nephrology, Regional Hospital Lugano, Lugano, 6900, Switzerland. pietro.cippa@eoc.ch.
3
Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, 90033-9080, CA, USA.
4
Molecular and Computational Biology, University of Southern California, Los Angeles, 90089-2910, CA, USA.
5
Department of Microbiology and Immunology, KU Leuven, Leuven, 3000, Belgium.
6
Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, 3000, Belgium.
7
Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, 90033-9080, CA, USA. amcmahon@med.usc.edu.
Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells
Montel-Hagen wt al.
Cell Stem Cell
March 2019
Authors and Affiliates
Montel-Hagen A1, Seet CS2, Li S3, Chick B1, Zhu Y1, Chang P4, Tsai S5, Sun V4, Lopez S1, Chen HC1, He C1, Chin CJ1, Casero D1, Crooks GM6
1
Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
2
Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.
3
Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA; Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.
4
Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA; Molecular Biology Interdepartmental Program, UCLA, Los Angeles, CA, USA.
5
Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
6
Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA; Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA; Division of Pediatric Hematology-Oncology, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. Electronic address: gcrooks@mednet.ucla.edu
Association of Tumor Microenvironment T-Cell Repertoire and Mutational Load With Clinical Outcome After Sequential Checkpoint Blockade in Melanoma
Yusko et al.
Cancer Immunology Research
March 2019
Authors and Affiliates
Yusko E1, Vignali M1, Wilson RK2, Mardis ER2, Hodi FS3, Horak C4, Chang H4, Woods DM5, Robins H1,6, Weber J7
1
Adaptive Biotechnologies, Seattle, Washington.
2
McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri.
3
Dana-Farber Cancer Center, Boston, Massachusetts.
4
Bristol-Myers Squibb, Princeton, New Jersey.
5
Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center, New York, New York.
6
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
7
Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center, New York, New York.
Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire.
Lu et al.
Nature Communications
March 2019
Authors and Affiliates
Lu J1, Van Laethem F2, Bhattacharya A2, Craveiro M2, Saba I2, Chu J1, Love NC2, Tikhonova A2, Radaev S1, Sun X3, Ko A3, Arnon T4,5, Shifrut E4, Friedman N4, Weng NP3, Singer A6, Sun PD7
1
Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA.
2
Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA.
3
Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institute of Health, Baltimore, MD, 21224, USA.
4
Department of Immunology, Weizmann Institute of Science, 76100, Rehovot, Israel.
5
Department of Physics and Astronomy, Alfred University, 1 Saxon Drive, Alfred, NY, 14802, USA.
6
Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA. singera@nih.gov.
7
Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA. psun@nih.gov.
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
Miller et al.
Nature Immunology
March 2019
Authors and Affiliates
Miller BC1,2,3,4,5, Sen DR1,3,6, Al Abosy R1,3, Bi K1,3, Virkud YV7, LaFleur MW1,3,4,5,6, Yates KB1,3, Lako A8, Felt K8, Naik GS8, Manos M2,8, Gjini E2,8, Kuchroo JR4,5,6, Ishizuka JJ1,2,3, Collier JL1,3,4,5,6, Griffin GK1,3,9, Maleri S4,5, Comstock DE1,3,6, Weiss SA1,3,6, Brown FD1,3,4,5,6, Panda A1,3, Zimmer MD3, Manguso RT3, Hodi FS2,8, Rodig SJ8,9, Sharpe AH3,4,5,6, Haining WN10,11,12
1
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
2
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
3
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
4
Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
5
Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
6
Division of Medical Sciences, Harvard Medical School, Boston, MA, USA.
7
Division of Pediatric Allergy and Immunology, Massachusetts General Hospital, Boston, MA, USA.
8
Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
9
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
10
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. wnhaining@gmail.com.
11
Broad Institute of MIT and Harvard, Cambridge, MA, USA. wnhaining@gmail.com.
12
Division of Medical Sciences, Harvard Medical School, Boston, MA, USA. wnhaining@gmail.com
Helios+ and Helios− Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires
Thornton et al.
European Journal of Immunology
March 2019
Authors and Affiliates
Thornton AM1, Lu J2, Korty PE1, Kim YC1, Martens C3, Sun PD2, Shevach EM1
1
Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
2
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
3
Rocky Mountain Laboratories Genomics Unit, Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
Fischer et al.
Cancer Discovery
February 2019
Authors and Affiliates
Fischer GM1,2,3, Jalali A4, Kircher DA5, Lee WC6, McQuade JL2, Haydu LE7, Joon AY8, Reuben A9, de Macedo MP10, Carapeto FCL3, Yang C11, Srivastava A12, Ambati CR13,14, Sreekumar A13,14, Hudgens CW3, Knighton B2, Deng W2, Ferguson SD15, Tawbi HA2, Glitza IC2, Gershenwald JE1,7, Vashisht Gopal YN2,3, Hwu P2, Huse JT3,16, Wargo JA6,7, Futreal PA6, Putluri N13,14, Lazar AJ3,6,16, DeBerardinis RJ11,17, Marszalek JR18, Zhang J6, Holmen SL5,19, Tetzlaff MT3,16, Davies MA20,3,21
1
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
2
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
3
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
4
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
5
Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah.
6
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
7
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
8
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
9
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
10
Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil.
11
Children's Medical Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
12
Department of Computational Sciences, The Jackson Lab for Genomic Medicine, Farmington, Connecticut.
13
Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
14
Advanced Technology Core, Alkek Center for Molecular Discovery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
15
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
16
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
17
Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
18
Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.
19
Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah.
20
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. mdavies@mdanderson.org.
21
Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells
Çuburu et al.
Journal of Immunology
February 2019
Authors and Affiliates
Çuburu N1, Kim R2, Guittard GC3, Thompson CD2, Day PM2, Hamm DE4, Pang YS2, Graham BS5, Lowy DR2, Schiller JT1.
1
Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; cuburun@mail.nih.gov schillej@mail.nih.gov.
2
Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
3
Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
4
Adaptive Biotechnologies, Seattle, WA 98102; and.
5
Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.