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The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity

Palakurthi et al.
Cancer Immunology Research
July 2019
Authors and Affiliates
Palakurthi S#1, Kuraguchi M#1, Zacharek SJ#1, Zudaire E#2, Huang W1, Bonal DM3, Liu J1, Dhaneshwar A1, DePeaux K1, Gowaski MR1, Bailey D1, Regan SN1, Ivanova E1, Ferrante C2, English JM1, Khosla A4, Beck AH4, Rytlewski JA5, Sanders C5, Laquerre S2, Bittinger MA1, Kirschmeier PT1, Packman K2, Janne PA1,6, Moy C2, Wong KK1,7, Verona RI#8, Lorenzi MV8; 1 Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts. 2 Janssen, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania. 3 Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, Massachusetts. 4 PathAI, Boston, Massachusetts. 5 Adaptive Biotechnologies, Seattle, Washington. 6 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. 7 Laura & Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York University, New York, New York. 8 Janssen, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania. rverona@its.jnj.com mlorenzi@its.jnj.com. # Contributed equally

A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor- induced encephalitis

Johnson et al.
Nature Medicine
July 2019
Authors and Affiliates
Johnson DB1,2, McDonnell WJ3,4,5,6,7, Gonzalez-Ericsson PI8, Al-Rohil RN5,9, Mobley BC5, Salem JE3,10, Wang DY3, Sanchez V5, Wang Y11, Chastain CA3, Barker K12, Liang Y12, Warren S12, Beechem JM12, Menzies AM13,14,15,16, Tio M13, Long GV13,14,15,16, Cohen JV17, Guidon AC17, O'Hare M17, Chandra S18, Chowdhary A18, Lebrun-Vignes B10, Goldinger SM19, Rushing EJ20, Buchbinder EI21, Mallal SA3,4,5,6,22, Shi C5, Xu Y11, Moslehi JJ3, Sanders ME5, Sosman JA23, Balko JM24,25,26,27; 1 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. douglas.b.johnson@vumc.org. 2 Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. douglas.b.johnson@vumc.org. 3 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. 4 Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. 5 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. 6 Center for Translational Immunology and Infectious Disease, Vanderbilt University Medical Center, Nashville, TN, USA. 7 Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. 8 Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, TN, USA. 9 Department of Pathology and Dermatology, Duke University Medical Center, Durham, NC, USA. 10 Sorbonne Université, INSERM CIC Paris-Est, AP-HP, ICAN, Regional Pharmacovigilance Centre, Pitié-Salpêtrière Hospital, Department of Pharmacology, Paris, France. 11 Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. 12 NanoString Technologies, Seattle, WA, USA. 13 Melanoma Institute Australia, Sydney, Australia. 14 The University of Sydney, Sydney, New South Wales, Australia. 15 Royal North Shore Hospital, Sydney, New South Wales, Australia. 16 Mater Hospital, Sydney, New South Wales, Australia. 17 Massachusetts General Hospital, Boston, MA, USA. 18 Feinberg School of Medicine, Northwestern University, Evanston, IL, USA. 19 Department of Dermatology, University Hospital, Zurich, Switzerland. 20 Institute of Neuropathology, University Hospital, Zurich, Switzerland. 21 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 22 Institute for Immunology and Infectious Diseases, Perth, Australia. 23 Northwestern Feinberg School of Medicine, Chicago, IL, USA. 24 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. justin.balko@vumc.org. 25 Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. justin.balko@vumc.org. 26 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. justin.balko@vumc.org. 27 Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, TN, USA. justin.balko@vumc.org.

Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer

Berner et al.
JAMA Oncology
July 2019
Authors and Affiliates
Fiamma Berner 1, David Bomze 2, Stefan Diem 2 3 4, Omar Hasan Ali 2 3 5 6, Mirjam Fässler 2 6, Sandra Ring 1 2, Rebekka Niederer 2 6, Christoph J Ackermann 3, Petra Baumgaertner 7, Natalia Pikor 2, Cristina Gil Cruz 2, Willem van de Veen 8 9, Mübeccel Akdis 8, Sergey Nikolaev 10 11, Heinz Läubli 12 13, Alfred Zippelius 12 13, Fabienne Hartmann 2, Hung-Wei Cheng 2, Gideon Hönger 14 15 16, Mike Recher 17, Jonathan Goldman 18, Antonio Cozzio 6, Martin Früh 3 19, Jacques Neefjes 20, Christoph Driessen 2 3, Burkhard Ludewig 2, Ahmed N Hegazy 21 22, Wolfram Jochum 23, Daniel E Speiser 7, Lukas Flatz 2 3 5 6; 1Microbiology and Immunology PhD Program, University of Zurich, Zurich, Switzerland. 2Institute of Immunobiology, Kantonsspital St Gallen, St Gallen, Switzerland. 3Department of Oncology and Haematology, Kantonsspital St Gallen, St Gallen, Switzerland. 4Department of Oncology and Haematology, Spital Grabs, Grabs, Switzerland. 5Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. 6Department of Dermatology and Allergology, Kantonsspital St Gallen, St Gallen, Switzerland. 7Department of Oncology, Ludwig Cancer Research, University of Lausanne, Lausanne, Switzerland. 8Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland. 9Christine Kühne - Center for Allergy Research and Education, Davos, Switzerland. 10Gustave Roussy Cancer Campus, Villejuif, France. 11University Paris 7, St Louis Hospital, Paris, France. 12Cancer Immunology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland. 13Division of Oncology, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland. 14Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland. 15HLA-Diagnostics and Immunogenetics, Department of Laboratory Medicine, University Hospital Basel, Basel, Switzerland. 16Transplantation Immunology and Nephrology, Department of Biomedicine, University Basel, Basel, Switzerland. 17Immunodeficiency Clinic and Immunodeficiency Lab, Medical Outpatient Unit and Department Biomedicine, University Hospital Basel, Basel, Switzerland. 18David Geffen School of Medicine, Department of Medicine, UCLA (University of California, Los Angeles), Ronald Reagan UCLA Medical Center, Santa Monica. 19University of Bern, Bern, Switzerland. 20Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. 21Medical Department for Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Berlin, Germany. 22Berlin Institute of Health, Berlin, Germany. 23Institute of Pathology, Kantonsspital St Gallen, St Gallen, Switzerland.

Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer

Wang et al.
Nature Immunology
July 2019
Authors and Affiliates
Wang L1, Simons DL1, Lu X2, Tu TY1, Solomon S1, Wang R1, Rosario A1, Avalos C1, Schmolze D3, Yim J4, Waisman J5, Lee PP6.; 1 Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. 2 Department of Biostatistics, University of California, Los Angeles, Los Angeles, CA, USA. 3 Department of Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. 4 Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. 5 Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. 6 Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. plee@coh.org.

Human CD4+ CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals

Klicznik et al.
Science Immunology
July 2019
Authors and Affiliates
Klicznik MM1, Morawski PA2, Höllbacher B1,2, Varkhande SR1, Motley SJ2, Kuri-Cervantes L3, Goodwin E3, Rosenblum MD4, Long SA2, Brachtl G5, Duhen T2, Betts MR3, Campbell DJ6,7, Gratz IK8,2,9; 1 Department of Biosciences, University of Salzburg, Salzburg, Austria. 2 Benaroya Research Institute, Seattle, WA 98101, USA. 3 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 4 Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. 5 Experimental and Clinical Cell Therapy Institute, Spinal Cord and Tissue Regeneration Center, Paracelsus Medical University, Salzburg, Austria. 6 Benaroya Research Institute, Seattle, WA 98101, USA. campbell@benaroyaresearch.org iris.gratz@sbg.ac.at. 7 Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA. 8 Department of Biosciences, University of Salzburg, Salzburg, Austria. campbell@benaroyaresearch.org iris.gratz@sbg.ac.at. 9 EB House Austria, Department of Dermatology, University Hospital of the Paracelsus Medical University, Salzburg, Austria.

CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK1 lymphoma after transplantation

Rajan et al.
Blood Advances
June 2019
Authors and Affiliates
Rajan SS1,2, Li L2,3, Kweh MF2,3, Kunkalla K2,4, Amin AD2,3, Agarwal NK2,4, Vega F2,4, Schatz JH2,3; Author information 1 Sheila and David Fuente Graduate Program in Cancer Biology. 2 Sylvester Comprehensive Cancer Center. 3 Division of Hematology, Department of Medicine, and. 4 Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

Chapuis et al.
Nature Medicine
June 2019
Authors and Affiliates
Chapuis AG1,2,3, Egan DN2,3, Bar M2,3, Schmitt TM1,2, McAfee MS1,2, Paulson KG1,2,3, Voillet V4, Gottardo R4,5, Ragnarsson GB1,2,6, Bleakley M1,2,3, Yeung CC2,3, Muhlhauser P3, Nguyen HN1,7, Kropp LA1,2,8, Castelli L1,2,8, Wagener F1,2, Hunter D1,2, Lindberg M1,2,9, Cohen K4, Seese A4, McElrath MJ2,3,4, Duerkopp N1,2, Gooley TA2,5, Greenberg PD10,11,12,13. Author information 1 Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 3 University of Washington School of Medicine, Seattle, WA, USA. 4 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 5 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 6 Landspítali Háskólasjúkrahús, Reykjavík, Iceland. 7 Alpine Biotech, Seattle, WA, USA. 8 Therapeutic Products Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 9 School of Informatics, University of Edinburgh, Edinburgh, UK. 10 Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. pgreen@u.washington.edu. 11 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. pgreen@u.washington.edu. 12 University of Washington School of Medicine, Seattle, WA, USA. pgreen@u.washington.edu. 13 Departments of Immunology and Medicine, University of Washington, Seattle, WA, USA. pgreen@u.washington.edu.

Defining Virus-specific CD8+ TCR Repertoires for Therapeutic Regeneration of T Cells against Chronic Hepatitis E

Soon et al.
Journal of Hepatology
June 2019
Authors and Affiliates
Soon CF1, Behrendt P2, Todt D3, Manns MP1, Wedemeyer H4, Sällberg Chen M5, Cornberg M6. Author information 1 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. 2 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), partner site Hannover, Braunschweig, Germany; Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research. 3 Department for Molecular and Medical Virology, Ruhr-Universität Bochum, Bochum, Germany. 4 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), partner site Hannover, Braunschweig, Germany; Department of Gastroenterology and Hepatology, University Clinic Essen, Essen, Germany. 5 Department of Dental Medicine and Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. 6 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), partner site Hannover, Braunschweig, Germany; Centre for Individualised Infection Medicine (CIIM), Hannover, Germany; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany. Electronic address: Cornberg.Markus@mh-hannover.de.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

Wong et al.
Communications Biology
June 2019
Authors and Affiliates
Wong EB#1,2,3,4, Gold MC#5,6,7, Meermeier EW5, Xulu BZ1, Khuzwayo S1, Sullivan ZA1, Mahyari E8, Rogers Z1, Kløverpris H1,4,9, Sharma PK6, Worley AH6, Lalloo U10, Baijnath P10,11, Ambaram A11, Naidoo L11, Suleman M11,12, Madansein R13,14, McLaren JE15, Ladell K15, Miners KL15, Price DA15,16, Behar SM17, Nielsen M18,19, Kasprowicz VO1,20,21, Leslie A1,4, Bishai WR22, Ndung'u T1,19,20,21,23, Lewinsohn DM5,6,7. Author information 1 1Africa Health Research Institute, KwaZulu-Natal, South Africa. 2 2Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA USA. 3 3Harvard Medical School, Boston, MA USA. 4 4Division of Infection and Immunity, University College London, London, UK. 5 5Department of Pulmonary & Critical Care Medicine, Oregon Health & Science University, Portland, OR USA. 6 6VA Portland Health Care System, Portland, OR USA. 7 7Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR USA. 8 8Division of Bioinformatics and Computational Biology (BCB), Department of Medical Informatics and Clinical Epidemiology (DMICE), Oregon Health & Science University, Portland, OR USA. 9 9Institute for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. 10 10Durban University of Technology, Durban, South Africa. 11 Department of Pulmonology, Inkosi Albert Luthuli Hospital, Durban, South Africa. 12 12Department of Pulmonology & Critical Care, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 13 13Department of Cardiothoracic Surgery, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 14 14Centre for AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. 15 15Institute of Infection & Immunity, Cardiff University School of Medicine, Cardiff, Wales UK. 16 16Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA. 17 17Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA USA. 18 18Center for Biological Sequence Analysis, Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark. 19 19Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, Buenos Aires, Argentina. 20 20HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 21 21The Ragon Institute of MGH, MIT, and Harvard, Harvard Medical School, Cambridge, MA USA. 22 22Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD USA. 23 23Max Planck Institute for Infection Biology, Berlin, Germany. # Contributed equally

A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen

Ahmed et al.
Cell
May 2019
Authors and Affiliates
Ahmed R1, Omidian Z1, Giwa A2, Cornwell B1, Majety N1, Bell DR3, Lee S3, Zhang H4, Michels A5, Desiderio S6, Sadegh-Nasseri S1, Rabb H7, Gritsch S8, Suva ML9, Cahan P10, Zhou R11, Jie C12, Donner T7, Hamad ARA13; Author information 1 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 2 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 3 Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA. 4 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. 5 Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO 80045, USA. 6 Department of Molecular Biology and Genetics and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 7 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 8 Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. 9 Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. 10 Department of Molecular Biology and Genetics and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 11 Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA. Electronic address: rz24@columbia.edu. 12 Department of Biochemistry and Nutrition, Des Moines University, Des Moines, IA 50312, USA. 13 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: ahamad@jhmi.edu.
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