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Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma

Rajan et al.
Journal for ImmunoTherapy of Cancer
October 2019
Authors and Affiliates
Rajan A1, Heery CR2, Thomas A3, Mammen AL4, Perry S3, O'Sullivan Coyne G5, Guha U3, Berman A3, Szabo E3,6, Madan RA5, Ballester LY7, Pittaluga S7, Donahue RN2, Tsai YT2, Lepone LM2, Chin K8, Ginty F9, Sood A9, Hewitt SM7, Schlom J2, Hassan R3, Gulley JL10; 1 Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CRC, Room 4-5330, 10 Center Drive, Bethesda, MD, 20892, USA. rajana@mail.nih.gov. 2 Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 3 Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CRC, Room 4-5330, 10 Center Drive, Bethesda, MD, 20892, USA. 4 Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. 5 Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., 13N240, Bethesda, MD, 20892, USA. 6 Lung and Upper Aerodigestive Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 7 Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 8 EMD Serono, Billerica, MA, USA. 9 GE Global Research Center, Niskayuna, NY, USA. 10 Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., 13N240, Bethesda, MD, 20892, USA. gulleyj@mail.nih.gov.

T cell repertoire remodeling following post-transplant T cell therapy coincides with clinical response

Smith et al.
Journal of Clinical Investigation
October 2019
Authors and Affiliates
Smith C1,2, Corvino D1, Beagley L1, Rehan S1, Neller MA1, Crooks P1, Matthews KK1, Solomon M1, Le Texier L1, Campbell S3,4, Francis RS3,4, Chambers D4,5, Khanna R1,4.; 1 QIMR Centre for Immunotherapy and Vaccine Development, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 2 School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia. 3 Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia. 4 School of Clinical Medicine, The University of Queensland, Brisbane, Queensland, Australia. 5 Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, Queensland, Australia.

Low-grade glioma harbors few CD8 t cells, which is accompanied by decreased expression of chemo- attractants, not immunogenic antigens

Weenink et al.
Scientific Reports
October 2019
Authors and Affiliates
Weenink B1, Draaisma K1, Ooi HZ1, Kros JM2, Sillevis Smitt PAE1, Debets R3, French PJ4; 1 Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. 2 Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. 3 Department of Medical Oncology, Laboratory of Tumor immunology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. 4 Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. p.french@erasmusmc.nl.

An innate-like Vd1 gd T cell compartment in the human breast is associated with remission in triple-negative breast cancer

Wu et al.
Science Translational Medicine
October 2019
Authors and Affiliates
Wu Y1,2,3,4, Kyle-Cezar F1,2, Woolf RT1,5, Naceur-Lombardelli C6, Owen J6, Biswas D4,7, Lorenc A1, Vantourout P1,2, Gazinska P3,8, Grigoriadis A3, Tutt A3,8, Hayday A9,2; 1 Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London SE1 9RT, UK. 2 Immunosurveillance Laboratory, Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. 3 Breast Cancer Now Research Unit, Innovation Hub, Cancer Centre at Guy's Hospital, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, UK. 4 Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, University College London, London WC1E 6DD, UK. 5 St John's Institute of Dermatology, King's College London, London SE1 9RT, UK. 6 KHP Cancer Biobank, Innovation Hub, Cancer Centre at Guy's Hospital, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, UK. 7 Bill Lyons Informatics Centre, University College London Cancer Institute, University College London, London WC1E 6DD, UK. 8 Breast Cancer Now Research Centre, Institute of Cancer Research, London SW3 6JB, UK. 9 Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London SE1 9RT, UK. adrian.hayday@kcl.ac.uk.

En masse discovery of anti-cancer human monoclonal antibodies by de novo assembly of immunoglobulin sequences from transcriptomes and genome sequences of cancer tissues

Zhang et al.
Cellular & Molecular Immunology
September 2019
Authors and Affiliates
Zhang P1, Chou HY1,2, Young L3, Zheng P4,5, Liu Y6,7; 1 Division of Immunotherapy, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. 2 The Institute for Biomedical Sciences, The George Washington University, Washington, DC, 20037, USA. 3 Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, 20010, USA. 4 Division of Immunotherapy, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. PZheng@ihv.umaryland.edu. 5 OncoImmune, Inc, Rockville, MD, 20852, USA. PZheng@ihv.umaryland.edu. 6 Division of Immunotherapy, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. YaLiu@ihv.umaryland.edu. 7 OncoImmune, Inc, Rockville, MD, 20852, USA. YaLiu@ihv.umaryland.edu.

Distinct PLZF+CD8αα+ Unconventional T Cells Enriched in Liver Use a Cytotoxic Mechanism to Limit Autoimmunity

Sheng et al.
Journal of Immunology
September 2019
Authors and Affiliates
Sheng H1,2, Marrero I1,2, Maricic I1,2, Fanchiang SS1,2, Zhang S3, Sant'Angelo DB3, Kumar V4,2.; 1 Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093. 2 Torrey Pines Institute for Molecular Studies, San Diego, CA 92121; and. 3 Rutgers University, New Brunswick, NJ 08901. 4 Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093

mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes

Raybuck et al.
FASEB J
September 2019
Authors and Affiliates
Raybuck AL1, Lee K2, Cho SH1,3, Li J1, Thomas JW4, Boothby MR1,3,4,5.; 1 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 2 Department of Biomedical Science, Hallym University, Chuncheon, Gangwon-do, South Korea. 3 Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4), Vanderbilt University Medical Center, Nashville, Tennessee, USA. 4 Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 5 Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance

Rivadeneira et al.
Immunity
September 2019
Authors and Affiliates
Dayana B. Rivadeneira,1,2 Kristin DePeaux,1,2 Yiyang Wang,1,2,5 Aditi Kulkarni,4 Tracy Tabib,3 Ashley V. Menk,1,2 Padmavathi Sampath,2 Robert Lafyatis,3 Robert L. Ferris,1,2,4 Saumendra N. Sarkar,2 Stephen H. Thorne,2 and Greg M. Delgoffe1,2,4,6,*; 1Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA 2Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA 3Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 4Head and Neck Cancer SPORE, University of Pittsburgh, Pittsburgh, PA, USA 5School of Medicine, Tsinghua University, Beijing, China 6Lead Contact

IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development

Stier et al.
Journal of Immunology
September 2019
Authors and Affiliates
Stier MT1, Mitra R2, Nyhoff LE1, Goleniewska K3, Zhang J3, Puccetti MV1, Casanova HC1, Seegmiller AC1, Newcomb DC1,3, Kendall PL1,3, Eischen CM4, Peebles RS Jr5,3.; 1 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232. 2 Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107; and. 3 Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232. 4 Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107; and christine.eischen@jefferson.edu stokes.peebles@vanderbilt.edu. 5 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232; christine.eischen@jefferson.edu stokes.peebles@vanderbilt.edu.

Deletion of donor-reactive T cell clones after human liver transplant

Savage et al.
American Journal of Transplantation
September 2019
Authors and Affiliates
Savage TM1, Shonts BA1, Lau S1, Obradovic A1, Robins H2, Shaked A3, Shen Y4, Sykes M1,5,6; 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, New York. 2 Fred Hutchinson Cancer Research Center, Adaptive Biotechnologies, Inc., Seattle, Washington. 3 Division of Transplant Surgery, University of Pennsylvania, Philadelphia, Pennsylvania. 4 Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York. 5 Department of Microbiology & Immunology, Columbia University Medical Center, Columbia University, New York, New York. 6 Department of Surgery, Columbia University Medical Center, Columbia University, New York, New York.
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