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Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab
Casneuf et al.
Leukemia
May 2020
Authors and Affiliates
Tineke Casneuf1 Homer C. Adams III2 Niels W.C.J. van de Donk3 Yann Abraham1 Jaime Bald2 Greet Vanhoof1 Koen Van der Borght1 Tina Smets1 Brad Foulk2 Karl C. Nielsen2 Joshua Rusbuldt2 Amy Axel2
Andrew Lysaght4 Hugo Ceulemans1 Frederik Stevenaert1 Saad Z. Usmani5 Torben Plesner6
Herve Avet-Loiseau7 Inger Nijhof3 Tuna Mutis3 Jordan M. Schecter8 Christopher Chiu2 Nizar J. Bahlis9
1 Janssen Research & Development, Beerse, Belgium
2 Janssen Research & Development, LLC, Spring House, PA, USA
Department of Hematology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
3 Vejle Hospital and University of Southern Denmark,
4 Immuneering Corp, Cambridge, MA, USA 5 Levine Cancer Institute/Carolinas Healthcare System, Charlotte, NC, USA
6
Vejle, Denmark
7
Toulouse, France
8 9
Janssen Research & Development, LLC, Raritan, NJ, USA
Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, AB, Canada
T Cell Clonal Dynamics Determined by High-Resolution TCR-β Sequencing in Recipients after Allogeneic Hematopoietic Cell Transplantation
Leick et al.
Biology of Blood and Marrow Transplantation
May 2020
Authors and Affiliates
Mark Leick 1, Rachel M Gittelman 2, Erik Yusko 2, Catherine Sanders 2, Harlan Robins 2, Zachariah DeFilipp 1, Sarah Nikiforow 3, Jerome Ritz 3, Yi-Bin Chen 4
1Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, Massachusetts.
2Adaptive Biotechnologies, Seattle, Washington.
3Division of Hematological Malignancies, Dana-Farber Cancer Institute, Boston, Massachusetts.
4Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: ychen6@partners.org.
Feasibility and efficacy of CD19-targeted CAR T cells with concurrent ibrutinib for CLL after ibrutinib failure
Gauthier J, et al.
Blood
May 2020
Authors and Affiliates
Jordan Gauthier,1-3 Alexandre V. Hirayama,1,3 Janaki Purushe,1 Kevin A. Hay,1,4 James Lymp,5 Daniel H. Li,5 Cecilia C. S. Yeung,1,6 Alyssa Sheih,1
Barbara S. Pender,1 Reed M. Hawkins,1 Aesha Vakil,1 Tinh-Doan Phi,1 Rachel N. Steinmetz,1 Mazyar Shadman,1,2 Stanley R. Riddell,1-3
David G. Maloney,1-3 and Cameron J. Turtle1-3
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 2Division of Medical Oncology, Department of Medicine, University of
Washington, Seattle, WA; 3Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA; 4Department of Medicine,
University of British Columbia, Vancouver, BC, Canada; 5Juno Therapeutics, a Bristol-Myers Squibb Company, Seattle, WA; and 6Department of Pathology,
University of Washington, Seattle, WA
Somatic mTOR Mutation in Clonally Expanded T Lymphocytes Associated With Chronic Graft Versus Host Disease
Kim et al.
Nature Communications
May 2020
Authors and Affiliates
Daehong Kim 1 2, Giljun Park 1 2, Jani Huuhtanen 1 2, Sofie Lundgren 1 2, Rajiv K Khajuria 1, Ana M Hurtado 3, Cecilia Muñoz-Calleja 4, Laura Cardeñoso 5, Valle Gómez-García de Soria 6, Tzu Hua Chen-Liang 3, Samuli Eldfors 7, Pekka Ellonen 7, Sari Hannula 7, Matti Kankainen 1 2 8 9, Oscar Bruck 1 2 9, Anna Kreutzman 1 2, Urpu Salmenniemi 10, Tapio Lönnberg 11, Andrés Jerez 3, Maija Itälä-Remes 10, Mikko Myllymäki 1 2, Mikko A I Keränen 1 2 12, Satu Mustjoki 13 14 15;
1Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, 00290, Helsinki, Finland.
2Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, 00014, Helsinki, Finland.
3Hematology and Medical Oncology Department, Hospital Morales Meseguer. Centro Regional de Hemodonación, Universidad de Murcia, IMIB, 30008, Murcia, Spain.
4Department of Immunology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, 28006, Madrid, Spain.
5Department of Microbiology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, 28006, Madrid, Spain.
6Department of Hematology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, 28006, Madrid, Spain.
7Institute of Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland.
8Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland.
9iCAN Digital Precision Cancer Medicine, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland.
10Stem Cell transplantation unit, Turku University Hospital, 20521, Turku, Finland.
11Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland.
12Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, 00029, Helsinki, Finland.
13Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, 00290, Helsinki, Finland. satu.mustjoki@helsinki.fi.
14Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, 00014, Helsinki, Finland. satu.mustjoki@helsinki.fi.
15iCAN Digital Precision Cancer Medicine, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland. satu.mustjoki@helsinki.fi.
Genetic and Immune Changes Associated with Disease Progression under the Pressure of Oncolytic Therapy in A Neuroblastoma Outlier Patient
Franco-Luzon et al.
Cancers
April 2020
Authors and Affiliates
Lidia Franco-Luzón 1, Sandra García-Mulero 2 3, Rebeca Sanz-Pamplona 3, Gustavo Melen 4 5, David Ruano 5, Álvaro Lassaletta 5, Luís Madero 1 5 6, África González-Murillo 4 5, Manuel Ramírez 4 5; 1Children Oncohematology Foundation, 28079 Madrid, Spain.
2Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
3Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
4Biomedical Research Foundation, Niño Jesús Children Hospital, 28009 Madrid, Spain.
5La Princesa Institute of Health Research, 28006 Madrid, Spain.
6Oncohematology Unit, Hospital Infantil Universitario Niño Jesús, 28009 Madrid, Spain.
Blockade of BAFF Reshapes the Hepatic B Cell Receptor Repertoire and Attenuates Autoantibody Production in Cholestatic Liver Disease
Thapa et al.
Journal of Immunology
April 2020
Authors and Affiliates
Thapa M1, Tedesco D2, Gumber S3, Elrod EJ2, Han JH2, Kitchens WH4, Magliocca JF4, Adams AB4, Grakoui A1,5.;
1
Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329; manoj.thapa@emory.edu arash.grakoui@emory.edu.
2
Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329.
3
Division of Pathology and Laboratory Medicine, Yerkes Research Primate Center, Emory University School of Medicine, Atlanta, GA 30329.
4
Division of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30329; and.
5
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329.
Maternal T Cells in the Human Placental Villi Support an Allograft Response during Noninfectious Villitis
Enninga et al.
Journal of Immunology
April 2020
Authors and Affiliates
Elizabeth Ann L. Enninga,* Patrick Raber,† Reade A. Quinton,‡ Rodrigo Ruano,* Nadia Ikumi,x Clive M. Gray,x Erica L. Johnson,{ Rana Chakraborty,*,‖,# and Sarah E. Kerr**; *Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905; †Adaptive Biotechnologies, Seattle, WA 98102; ‡Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905; xDivision of Immunology, In- stitute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Cape Town, South Africa 7791; {Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322; ‖Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905; #Department of Immunology, Mayo Clinic, Rochester, MN 55905; and **Hospital Pathology Associates, Minneapolis, MN 55407
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma
Mitra et al.
Nature Communications
April 2020
Authors and Affiliates
Akash Mitra, Miles C. Andrews, Whijae Roh, Marianna Petaccia De Macedo, Courtney W. Hudgens, Fernando Carapeto, Shailbala Singh, Alexandre Reuben, Feng Wang, Xizeng Mao, Xingzhi Song, Khalida Wani, Samantha Tippen, Kwok-Shing Ng, Aislyn Schalck, Donald A. Sakellariou-Thompson, Eveline Chen, Sangeetha M. Reddy, Christine N. Spencer, Diana Wiesnoski, Latasha D. Little, Curtis Gumbs, Zachary A. Cooper, Elizabeth M. Burton, Patrick Hwu, Michael A. Davies, Jianhua Zhang, Chantale Bernatchez, Nicholas Navin, Padmanee Sharma, James P. Allison, Jennifer A. Wargo, Cassian Yee, Michael T. Tetzlaff, Wen-Jen Hwu, Alexander J. Lazar & P. Andrew Futreal; 1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
2Quantitative Sciences Graduate Training Program, Graduate School of Biomedical Sciences, Houston, Texas, USA.
3Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
4Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University, Heidelberg, VIC, Australia.
5The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
6Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
7Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
8Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
9Institute for Personalized Cancer Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
10Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
11Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
12Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
13Parker Institute for Cancer Immunotherapy, San Francisco, California, USA.
14AstraZeneca, Gaithersburg, Maryland, USA.
15Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
16Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. AFutreal@mdanderson.org.
Cellular Origins and Genetic Landscape of Cutaneous Gamma Delta T Cell Lymphomas
Daniels et al.
Nature Communications
April 2020
Authors and Affiliates
Jay Daniels 1 2, Peter G Doukas 1, Maria E Martinez Escala 1, Kimberly G Ringbloom 1, David J H Shih 3, Jingyi Yang 1, Kyle Tegtmeyer 1, Joonhee Park 1, Jane J Thomas 1, Mehmet E Selli 1, Can Altunbulakli 1, Ragul Gowthaman 4 5, Samuel H Mo 6, Balaji Jothishankar 7, David R Pease 1, Barbara Pro 8, Farah R Abdulla 9, Christopher Shea 7, Nidhi Sahni 3 10 11 12, Alejandro A Gru 13 14, Brian G Pierce 4 5, Abner Louissaint Jr 15, Joan Guitart 16, Jaehyuk Choi 17 18 19 20; 1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
3Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
4University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.
5Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.
6University of Illinois College of Medicine, Chicago, IL, USA.
7Department of Medicine, Section of Dermatology, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
8Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
9Division of Dermatology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
10Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA.
11Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
12Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA.
13Department of Pathology, University of Virginia Health System, Charlottesville, VA, USA.
14Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.
15Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. alouissaint@partners.org.
16Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. JGUITART@nm.org.
17Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.
18Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.
19Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.
20Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.