Browse our 650+ Publications​

Latest Publications

Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development

Kury P., et al.
EBio Medicine
September 2020
Authors and Affiliates
Patrick Kury 1, Marita Führer 2, Sebastian Fuchs 3, Myriam R Lorenz 4, Orlando Bruno Giorgetti 5, Shahrzad Bakhtiar 6, Andreas P Frei 3, Paul Fisch 7, Thomas Boehm 5, Klaus Schwarz 8, Carsten Speckmann 9, Stephan Ehl 10; 1 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 115, 79106 Freiburg, Germany; Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, D-79104 Freiburg, Germany. 2 Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Baden-Wuerttemberg - Hessen, Ulm, Germany. 3 Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland. 4 Institute for Transfusion Medicine, University of Ulm, Ulm, Germany. 5 Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics Freiburg, Freiburg, Germany. 6 Division for Pediatric Stem-Cell Transplantation, Immunology and Intensive Medicine, University Hospital Frankfurt, Frankfurt/Main, Germany. 7 Department of Pathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 8 Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Baden-Wuerttemberg - Hessen, Ulm, Germany; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany. 9 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 115, 79106 Freiburg, Germany; Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 10 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 115, 79106 Freiburg, Germany; CIBBS -Centre for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany. Electronic address: stephan.ehl@uniklinik-freiburg.de.

Radiation induces dynamic changes to the T cell repertoire in renal cell carcinoma patients

Chow J., et al.
PNAS
September 2020
Authors and Affiliates
Jacky Chow 1, Nicholas C Hoffend 1, Scott I Abrams 1, Thomas Schwaab 1,2, Anurag K Singh 3, Jason B Muhitch 4,2; 1 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263. 2 Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263. 3 Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263. 4 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263; jason.muhitch@roswellpark.org.

Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases

Barennes P., et al.
Nature Biotechnology
September 2020
Authors and Affiliates
Pierre Barennes 1,2, Valentin Quiniou 1,2, Mikhail Shugay 3,4,5, Evgeniy S Egorov 4, Alexey N Davydov 6, Dmitriy M Chudakov 3,4,5,6, Imran Uddin 7, Mazlina Ismail 7, Theres Oakes 7, Benny Chain 7, Anne Eugster 8, Karl Kashofer 9, Peter P Rainer 10,11, Samuel Darko 12, Amy Ransier 12, Daniel C Douek 12, David Klatzmann 1,2, Encarnita Mariotti-Ferrandiz 13,14; 1 Sorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), Paris, France. 2 AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France. 3 Center of Life Sciences, Skoltech, Moscow, Russia. 4 Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. 5 Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia. 6 Adaptive Immunity Group, Central European Institute of Technology, Brno, Czechia. 7 Division of Infection and Immunity, University College London, London, UK. 8 DFG-Centre for Regenerative Therapies Dresden, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 9 Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria. 10 Division of Cardiology, Medical University of Graz, Graz, Austria. 11 BioTechMed-Graz, Graz, Austria. 12 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 13 Sorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), Paris, France. encarnita.mariotti@sorbonne-universite.fr. 14 AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France. encarnita.mariotti@sorbonne-universite.fr.

Ultra-efficient sequencing of T Cell receptor repertoires reveals shared responses in muscle from patients with Myositis

Montagne JM., et al.
EBio Medicine
September 2020
Authors and Affiliates
Janelle M Montagne 1, Xuwen Alice Zheng 1, Iago Pinal-Fernandez 2, Jose C Milisenda 3, Lisa Christopher-Stine 4, Thomas E Lloyd 5, Andrew L Mammen 2, H Benjamin Larman 6; 1 Division of Immunology, Pathology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 2 Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3 Internal Medicine Department, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain and Centro de Investigación Médica en Red Enfermedades Raras. 4 Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 5 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Division of Immunology, Pathology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: hlarman1@jhmi.edu.

Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate

Pandey A., et al.
Nature Communications
September 2020
Authors and Affiliates
Akhilesh Pandey 1,2,3, Eric W Stawiski 4,5,6, Steffen Durinck 7,8, Harsha Gowda 9,10, Leonard D Goldstein 7,8, Mustafa A Barbhuiya 9,11, Markus S Schröder 8,12, Sreelakshmi K Sreenivasamurthy 9, Sun-Whe Kim 13, Sameer Phalke 14, Kushal Suryamohan 15, Kayla Lee 15, Papia Chakraborty 15, Vasumathi Kode 15, Xiaoshan Shi 15, Aditi Chatterjee 9, Keshava Datta 9, Aafaque A Khan 9, Tejaswini Subbannayya 9, Jing Wang 15, Subhra Chaudhuri 8, Sanjiv Gupta 16, Braj Raj Shrivastav 17, Bijay S Jaiswal 8, Satish S Poojary 18, Shushruta Bhunia 18, Patricia Garcia 19, Carolina Bizama 19, Lorena Rosa 20, Wooil Kwon 13, Hongbeom Kim 13, Youngmin Han 13, Thakur Deen Yadav 21, Vedam L Ramprasad 14, Amitabha Chaudhuri 15, Zora Modrusan 8, Juan Carlos Roa 19, Pramod Kumar Tiwari 18, Jin-Young Jang 22, Somasekar Seshagiri 23,24; 1 Institute of Bioinformatics, Bangalore, Karnataka, 560066, India. pandey.akhilesh@mayo.edu. 2 Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India. pandey.akhilesh@mayo.edu. 3 Center for Individualized Medicine and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. pandey.akhilesh@mayo.edu. 4 Bioinformatics and Computational Biology Department, Genentech Inc, South San Francisco, CA, 94080, USA. eric.s@medgenome.com. 5 Molecular Biology Department, Genentech Inc., South San Francisco, CA, 94080, USA. eric.s@medgenome.com. 6 Research and Development Department, MedGenome Inc, Foster City, CA, 94404, USA. eric.s@medgenome.com. 7 Bioinformatics and Computational Biology Department, Genentech Inc, South San Francisco, CA, 94080, USA. 8 Molecular Biology Department, Genentech Inc., South San Francisco, CA, 94080, USA. 9 Institute of Bioinformatics, Bangalore, Karnataka, 560066, India. 10 QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. 11 Department of Pathology and Laboratory Medicine, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA. 12 SciGenom Labs, Cochin, Kerala, 682037, India. 13 Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, 08826, South Korea. 14 Research and Development Department, MedGenome Labs Pvt. Ltd., Bangalore, Karnataka, 560099, India. 15 Research and Development Department, MedGenome Inc, Foster City, CA, 94404, USA. 16 Department of Pathology, Cancer Hospital and Research Institute, Gwalior, Madhya Pradesh, 474009, India. 17 Department of Surgical Oncology, Cancer Hospital and Research Institute, Gwalior, Madhya Pradesh, 474009, India. 18 Jiwaji University, Gwalior, Madhya Pradesh, 474011, India. 19 Department of Pathology, Millennium Institute on Immunology and Immunotherapy, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. 20 Applied Molecular and Cellular Biology PhD Program Universidad De la Frontera, Temuco, Chile. 21 Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. 22 Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, 08826, South Korea. jangjy4@snu.ac.kr. 23 Molecular Biology Department, Genentech Inc., South San Francisco, CA, 94080, USA. sekar@sgrf.org. 24 SciGenom Research Foundation, 3rd Floor, Narayana Nethralaya Building, Narayana Health City, #258/A, Bommasandra, Hosur Road, Bangalore, Karnataka, 560099, India. sekar@sgrf.org.

Hepatitis E Virus (HEV)-Specific T Cell Receptor Cross-Recognition: Implications for Immunotherapy

Soon CF., et al.
Frontiers in Immunology
September 2020
Authors and Affiliates
Chai Fen Soon 1,2, Shihong Zhang 1, Pothakamuri Venkata Suneetha 1, Dinler Amaral Antunes 3, Michael Peter Manns 1,2, Solaiman Raha 4, Christian Schultze-Florey 4,5, Immo Prinz 2,4, Heiner Wedemeyer 1,6,7, Margaret Sällberg Chen 8,9, Markus Cornberg 1,2,6,10,11; 1 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hanover, Germany. 2 Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hanover, Germany. 3 Department of Computer Science, Rice University, Houston, TX, United States. 4 Hannover Medical School, Institute of Immunology, Hanover, Germany. 5 Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany. 6 German Center for Infection Research, Partner Site Hannover-Braunschweig, Hanover, Germany. 7 Department of Gastroenterology and Hepatology, University Clinic Essen, Essen, Germany. 8 Department of Dental Medicine and Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. 9 Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. 10 Centre for Individualised Infection Medicine, Hanover, Germany. 11 Helmholtz Centre for Infection Research, Braunschweig, Germany.

A large-scale database of T-cell receptor beta (TCRB) sequences and binding associations from natural and synthetic exposure to SARS-CoV-2

Nolan S., et al.
September 2020
Authors and Affiliates
Sean Nolan, Marissa Vignali, Mark Klinger, Jennifer N. Dines, Ian M. Kaplan, Emily Svejnoha, Tracy Craft, Katie Boland, Mitch Pesesky, Rachel M. Gittelman, Thomas M. Snyder, Christopher J. Gooley, Simona Semprini, Claudio Cerchione, Massimiliano Mazza, Ottavia M. Delmonte, Kerry Dobbs, Gonzalo Carreño-Tarragona, Santiago Barrio, Vittorio Sambri, Giovanni Martinelli, Jason D. Goldman, James R. Heath, Luigi D. Notarangelo, Jonathan M. Carlson, Joaquin Martinez-Lopez, and Harlan S. Robins

T cell receptor diversity and lineage relationship between virus-specific CD8 T cell subsets during chronic LCMV infection

Chang YM., et al.
Journal of Virology
September 2020
Authors and Affiliates
Yun Min Chang 1,2,3, Andreas Wieland 1,2, Zheng-Rong Li 1,2,4, Se Jin Im 1,2,5, Donald J McGuire 1,2, Haydn T Kissick 1,2,6, Rustom Antia 1,4, Rafi Ahmed 7,2; 1 Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA. 2 Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA. 3 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA. 4 Department of Biology, Emory University, Atlanta, Georgia, USA. 5 Department of Immunology, Sungkyunkwan University School of Medicine, Suwon, Korea. 6 Department of Urology, Emory University School of Medicine, Atlanta, Georgia, USA. 7 Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA rahmed@emory.edu.

A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma

Cader FZ., et al.
Nature Medicine
September 2020
Authors and Affiliates
Fathima Zumla Cader 1,2, Xihao Hu 3,4,5, Walter L Goh 6, Kirsty Wienand 1,7, Jing Ouyang 1, Elisa Mandato 1, Robert Redd 3, Lee N Lawton 1, Pei-Hsuan Chen 8, Jason L Weirather 8, Ron C J Schackmann 6,9, Bo Li 3 4,10, Wenjiang Ma 1,11, Philippe Armand 1, Scott J Rodig 12, Donna Neuberg 3, X Shirley Liu 13,14, Margaret A Shipp 15; 1 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 2 AstraZeneca, City House, Cambridge, UK. 3 Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. 4 Harvard T.H. Chan School of Public Health, Boston, MA, USA. 5 GV20 Therapeutics LLC, Cambridge, MA, USA. 6 Department of Cell Biology, Harvard Medical School, Boston, MA, USA. 7 Department of Hematology and Oncology, Göttingen Comprehensive Cancer Center, Göttingen, Germany. 8 Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 9 Merus, Utrecht, the Netherlands. 10 Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA. 11 Clarion Healthcare, Boston, MA, USA. 12 Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. 13 Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. xsliu@ds.dfci.harvard.edu. 14 Harvard T.H. Chan School of Public Health, Boston, MA, USA. xsliu@ds.dfci.harvard.edu. 15 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Margaret_Shipp@dfci.harvard.edu.
Previous Next