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Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection

Magnoumba M., et al.
November 2020
Authors and Affiliates
Magalli Magnoumba 1, Alveera Singh 1, Paul Ogongo 1,2, Julia Roider 3,4, Osaretin Asowata 1, Michael Fehlings 5, Farina Karim 1, Thumbi Ndung'u 1,6,7, Frank Anderson 8, Alasdair Leslie 1,7, Henrik Kløverpris 1,7,9; 1 Africa Health Research Institute (AHRI), University of KwaZulu-Natal (UKZN), Durban, South Africa. 2 Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya. 3 Department of Infectious Diseases, Medizinische Klinik IV, Ludwig-Maximilians-University Munich, Munich, Germany. 4 German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. 5 ImmunoScape Pte Ltd, Singapore, Singapore. 6 HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa. 7 Division of Infection and Immunity, University College London (UCL), London, United Kingdom. 8 Department of Surgery, Inkosi Albert Luthuli Hospital, Durban, South Africa. 9 Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Isatuximab as monotherapy and combined with dexamethasone in patients with relapsed/refractory multiple myeloma

Dimopoulos MA., et al.
November 2020
Authors and Affiliates
Meletios A Dimopoulos 1, Sara Bringhen 2, Pekka M Anttila 3, Marcelo Capra 4, Michele Cavo 5, Craig Emmitt Cole 6, Cristina Gasparetto 7, Vania Tietsche de Moraes Hungria 8, Matthew W Jenner 9, Vladimir I Vorobyev 10, Eduardo Patricio Yanez Ruiz 11, Jian Y Yin 12, Rao Saleem 12, Maeva Hellet 13, Sandrine Macé 14, Bruno Paiva 15, Ravi Vij 16; 1 National and Kapodistrian University of Athens, Athens, Greece. 2 University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy. 3 Helsinki University and Helsinki University Hospital, Helksinki, Finland. 4 Hospital Mãe de Deus, Porto Alegre, Brazil. 5 Seràgnoli Institute of Hematology, Bologna, Italy. 6 Michigan State University, East Lansing, Michigan, United States. 7 Duke University. 8 Clinica Sao Germano, São Paulo, Brazil. 9 University Hospital Southampton, Southampton, United Kingdom. 10 S.P. Botkin Hospital, Moscow, Russian Federation. 11 Universidad de la Frontera, Temuco, Chile. 12 Sanofi, Bridgewater, New Jersey, United States. 13 Ividata (for Sanofi), Paris, France. 14 Sanofi, Paris, France. 15 Clinica Universidad de Navarra, Pamplona, Spain. 16 Washington University, St Louis, Missouri, United States.

CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17

Corgnac S, et al.
October 2020
Authors and Affiliates
Stephanie Corgnac,1 Ines Malenica,1 Laura Mezquita,2,9,10 Edouard Auclin,3,9 Elodie Voilin,1 Jamila Kacher,1 Heloise Halse,1 Laetitia Grynszpan,1 Nicolas Signolle,4 Thibault Dayris,5 Marine Leclerc,1 Nathalie Droin,5 Vincent de Montpreville,1,6 Olaf Mercier,6 Pierre Validire,7 Jean-Yves Scoazec,5 Christophe Massard,8 Salem Chouaib,1 David Planchard,2 Julien Adam,1,9 Benjamin Besse,2,9 and Fathia Mami-Chouaib1,11,*; 1 INSERM UMR 1186, Integrative Tumor Immunology and Immunotherapy, Gustave Roussy, Faculte de Medecine, Universite Paris-Sud, Universite Paris-Saclay, 94805 Villejuif, France 2 Department of Cancer Medicine, Gustave Roussy, Institut d’Oncologie Thoracique, Gustave Roussy, Universite Paris-Saclay, 94805 Villejuif, France 3 Gastrointestinal and Medical Oncology Department, Hopital Europe en Georges Pompidou, Paris, France 4 INSERM Unit U981, Department of Experimental Pathology, Gustave Roussy, Universite Paris-Sud, Universite Paris-Saclay, 94805 Villejuif, France 5 Department of Biology and Medical Pathology, Gustave Roussy, 94805 Villejuif, France 6 Hopital Marie-Lannelongue, Service d’Anatomie Pathologique, 92350 Le-Plessis-Robinson, France 7 Institut Mutualiste Montsouris, Service d’Anatomie Pathologique, 75014 Paris, France 8 Drug Development Department, Gustave Roussy, Universite Paris-Saclay, 94805 Villejuif, France 9 These authors contributed equally 10 Present address: Laboratory of Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), and Medical Oncology Department, Hospital Clinic, Barcelona, Spain 11 Lead Contact * Correspondence: fathia.mami-chouaib@gustaveroussy.fr

Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s

Oba T., et al.
October 2020
Authors and Affiliates
Takaaki Oba 1,8, Mark D. Long 2,8, Tibor Keler3, Henry C. Marsh 3, Hans Minderman 4, Scott I. Abrams 5,9, Song Liu2,9 & Fumito Ito 1,5,6,7; 1 Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 2 Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 3 Celldex Therapeutics, Inc., Hampton, NJ, USA. 4 Flow & Image Cytometry Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 5 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 6 Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 7 Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY, USA. 8 These authors contributed equally: Takaaki Oba, Mark D. Long. 9 These authors jointly supervised: Scott I. Abrams, Song Liu. email: fumito.ito@roswellpark.org

The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer

Mungenast F, et al.
October 2020
Authors and Affiliates
Felicitas Mungenast 1,†, Anastasia Meshcheryakova 1,†,*, Andrea Beer 2, Martina Salzmann 1, Dietmar Tamandl 3, Thomas Gruenberger 4,‡, Peter Pietschmann 1, Oskar Koperek 2,§, Peter Birner 2, Ilan Kirsch 5, Harlan Robins 5, Martina Mittlboeck 6, Markus Jaritz 7, Michael Bergmann 8, Philip Zimmermann 9 and Diana Mechtcheriakova 1,*; 1 Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna 1090, Austria; felicitas.mungenast@meduniwien.ac.at (F.M.); martina.salzmann@meduniwien.ac.at (M.S.); peter.pietschmann@meduniwien.ac.at (P.P.) 2 Department of Pathology, Medical University of Vienna, Vienna 1090, Austria; andrea.beer@meduniwien.ac.at (A.B.); Koperek@labor-kaserer.at (O.K.); peter.birner@meduniwien.ac.at (P.B.) 3 Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna 1090, Austria; dietmar.tamandl@meduniwien.ac.at 4 Department of Surgery, Kaiser Franz Josef Hospital, Vienna 1100, Austria; thomas.gruenberger@gesundheitsverbund.at 5 Adaptive Biotechnologies Corporation, Seattle, WA 98102, USA; lkirsch@adaptivebiotech.com (I.K.); hrobins@adaptivebiotech.com (H.R.) 6 Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna 1090, Austria; martina.mittlboeck@meduniwien.ac.at 7 Research Institute of Molecular Pathology, Vienna Biocenter, Vienna 1030, Austria; Markus.Jaritz@imp.ac.at 8 Department of Surgery, Medical University of Vienna, Vienna 1090, Austria; michael.bergmann@meduniwien.ac.at 9 Nebion AG, Zürich, 8048, Switzerland; phz@nebion.com * Correspondence: diana.mechtcheriakova@meduniwien.ac.at (D.M.); anastasia.meshcheryakova@meduniwien.ac.at (A.M.) † These authors contributed equally to this work. ‡ Current affiliation: Department of Surgery I, Rudolf Foundation Clinic, Vienna 1030, Austria. § Current affiliation: Clinical Pathology Laboratory Kaserer, Koperek and Beer, Vienna 1030, Austria.

Long-term Sculpting of the B-cell Repertoire following Cancer Immunotherapy in Patients Treated with Sipuleucel-T

Zhang L., et al.
Cancer Immunology Research
October 2020
Authors and Affiliates
Li Zhang 1,2, Harini Kandadi 3, Hai Yang 2, Jason Cham 1 4, Tao He 5, David Y Oh 1, Nadeem A Sheikh 3, Lawrence Fong 6; 1 Department of Medicine, University of California San Francisco, San Francisco, California. 2 Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, California. 3 Dendreon Pharmaceuticals LLC, Seattle, Washington. 4 Department of Internal Medicine, Scripps Green Hospital, La Jolla, California. 5 Department of Mathematics, San Francisco State University, San Francisco, California. 6 Department of Medicine, University of California San Francisco, San Francisco, California. lawrence.fong@ucsf.edu.

Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing

Coelho CH., et al.
JCI Insight
October 2020
Authors and Affiliates
Camila H Coelho 1, Steven T Nadakal 1, Patricia A Gonzales Hurtado 1, Robert Morrison 1, Jacob D Galson 2, Jillian Neal 1, Yimin Wu 3, C Richter King 3, Virginia Price 3, Kazutoyo Miura 4, Sharon Wong-Madden 1, Justin Ya Dortichamou 1, David L Narum 1, Nicholas J MacDonald 1, Maryonne Snow-Smith 1, Marissa Vignali 5, Justin J Taylor 6, Marie-Paule Lefranc 7, Johannes Trück 8, Carole A Long 4, Issaka Sagara 9, Michal Fried 1, Patrick E Duffy 1; 1 Laboratory for Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, NIH, Rockville, United States of America. 2 Department of Pediatrics, University Children's Hospital Zürich, Zürich, Switzerland. 3 PATH's Malaria Vaccine Initiative, Washington DC, United States of America. 4 Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, United States of America. 5 Adaptive Biotechnologies, Inc., Seattle, United States of America. 6 Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America. 7 Institut de Génétique Humaine, Université Montpellier 2, Montpellier, France. 8 Department of Immunology, University Children's Hospital Zürich, Zürich, Switzerland. 9 Malaria Research and Training Center, University of Bamako, Bamako, Mali.

Circulating α4β7+ Memory T Cells in Pediatric IBD Patients Express a Polyclonal T Cell Receptor Repertoire

Gamliel A., et al.
Clinical and Experimental Gastroenterology
October 2020
Authors and Affiliates
Adir Gamliel 1,2, Lael Werner 1,2, Marina Pinsker 1,3, Naomi Salamon 1, Batia Weiss 1,2, Dror S Shouval 1,2; 1 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat Gan, Israel 2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 3 Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, Israel

Adherent cell depletion promotes the expansion of renal cell carcinoma infiltrating T cells with optimal characteristics for adoptive transfer

Braun MW., et al.
Journal for ImmunoTherapy of Cancer
October 2020
Authors and Affiliates
Mitchell W Braun 1, Haitham Abdelhakim 2, Meizhang Li 1, Stephen Hyter 1, Ziyan Pessetto 1, Devin C Koestler 3, Harsh B Pathak 1,4, Neil Dunavin 5,6, Andrew K Godwin 7,4; 1 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA. 2 Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA. 3 Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA. 4 The University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas, USA. 5 UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA. 6 Division on Hematology and BMT, UCSF, San Francisco, California, USA. 7 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA agodwin@kumc.edu.

T cell repertoire analysis suggest a prominent bystander response in human cardiac allograft vasculopathy

Habal MV., et al.
American Journal of Transplantation
October 2020
Authors and Affiliates
Marlena V Habal 1,2, April M I Miller 1,3, Samhita Rao 1, Sijie Lin 1,4, Aleksandar Obradovic 1, Mohsen Khosravi-Maharlooei 1, Sarah See 1, Poulomi Roy 1, Shihab Ronzon 1, Siu-Hong Ho 1,5, Charles Marboe 6, Yoshifumi Naka 7, Koji Takeda 7, Susan Restaino 2, Arnold Han 1, Donna Mancini 8, Michael Givertz 9, Joren C Madsen 10,11, Megan Sykes 1, Linda Addonizio 12, Maryjane Farr 2, Emmanuel Zorn 1; 1 Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA. 2 Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, NY, USA. 3 Case Western Reserve University School of Medicine, NY, USA. 4 Stanford University, Department of Genetics, NY, USA. 5 Cytek Biosciences, NY, USA. 6 Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. 7 Department of Surgery, Division of Cardiothoracic Surgery, Columbia University Irving Medical Center, New York, NY, USA. 8 Department of Medicine, Mount Sinai Hospital, Icahn School of Medicine, New York, NY, USA. 9 Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 10 Center for Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 11 Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 12 Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Irving Medical Center, New York, NY, USA.