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Human-engineered Treg-like cells suppress FOXP3-deficient T cells but preserve adaptive immune responses in vivo
Sato Y., et al.
December 2020
Authors and Affiliates
Yohei Sato 1, Laura Passerini 2, Brian D Piening 3, Molly Javier Uyeda 1,4, Marianne Goodwin 1, Silvia Gregori 2, Michael P Snyder 5, Alice Bertaina 1, Maria-Grazia Roncarolo 1,4,6, Rosa Bacchetta 1,6;
1 Department of Pediatrics Division of Hematology, Oncology Stem Cell Transplantation and Regenerative Medicine Stanford University School of Medicine Stanford CA USA.
2 Mechanisms of Peripheral Tolerance Unit San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) IRCCS San Raffaele Scientific Institute Milan Italy.
3 Earle A Chiles Research Institute Providence Portland Medical Center Portland OR USA.
4 Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of Medicine Stanford CA USA.
5 Department of Genetics Stanford University School of Medicine Stanford CA USA.
6 Center for Definitive and Curative Medicine (CDCM) Stanford University School of Medicine Stanford CA USA.
Antigen-driven clonal selection shapes the persistence of HIV-1 infected CD4+ T cells in vivo
Simonetti FR., et al.
December 2020
Authors and Affiliates
Francesco R Simonetti 1, Hao Zhang 2, Garshasb P Soroosh 1, Jiayi Duan 1, Kyle Rhodehouse 1, Alison L Hill 3, Subul A Beg 1, Kevin McCormick 4, Hayley E Raymond 4, Christopher L Nobles 4, John K Everett 4, Kyungyoon J Kwon 1, Jennifer A White 1, Jun Lai 1, Joseph B Margolick 5, Rebecca Hoh 6, Steven G Deeks 6, Frederic D Bushman 4, Janet D Siliciano 1, Robert F Siliciano 1;
1 Department of Medicine, Johns Hopkins University, Baltimore, United States of America.
2 Department of Molecular Microbiology and immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.
3 Department for Organismic and Evolutionary Biology, Harvard University, Cambridge, United States of America.
4 Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America.
5 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltiomore, United States of America.
6 Division of HIV, Infectious Diseases, and Global Medicine, UCSF, San Francisco, United States of America.
STAT3 Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti-PD-L1
Proia TA., et al.
December 2020
Authors and Affiliates
Theresa A Proia 1, Maneesh Singh 1, Richard Woessner 2, Larissa Carnevalli 3, Gayathri Bommakanti 1, Lukasz Magiera 3, Srimathi Srinivasan 4, Shaun Grosskurth 5, Mike Collins 6, Chris Womack 7, Matthew Griffin 1, Minwei Ye 1, Susan Cantin 1, Deanna Russell 4, Mingchao Xie 4, Adina Hughes 3, Nanhua Deng 8, Deanna A Mele 1, Stephen Fawell 1, Simon Barry 3, Corinne Reimer 1, J Carl Barrett 4, Patricia McCoon 9;
1 Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts.
2 Blueprint Medicines, Cambridge, Massachusetts.
3 Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.
4 Translational Medicine, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts.
5 AbbVie, Lake County, Illinois.
6 Tufts University Graduate School of Biomedical Sciences, Medford, Massachusetts.
7 Womack Consulting, Stamford, UK.
8 GSK, Cambridge, Massachusetts.
9 Translational Medicine, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts. patricia.mccoon@astrazeneca.com.
Adoptive transfer of neoantigen-specific T-cell therapy is feasible in older patients with higher-risk myelodysplastic syndrome
Tanaka TN., et al.
December 2020
Authors and Affiliates
Tiffany N Tanaka 1, Valentina Ferrari 2, Alison Tarke 2, Hannah Fields 2, Luca Ferrari 2, Franco Ferrari 1, Colin L McCarthy 1, Amber P Sanchez 3, Antonella Vitiello 2, Thomas A Lane 2, Rafael Bejar 4;
1 University of California San Diego Moores Cancer Center, La Jolla, California, USA.
2 PersImmune, Inc, San Diego, California, USA.
3 University of California San Diego Apheresis Program and Division of Nephrology, La Jolla, California, USA.
4 University of California San Diego Moores Cancer Center, La Jolla, California, USA. Electronic address: rabejar@health.ucsd.edu.
Identification of HLA-A*02:01-restricted candidate epitopes derived from the non-structural polyprotein 1a of SARS-CoV-2 that may be natural targets of CD8 + T cell recognition in vivo
Takagi A, Matsui M.
December 2020
Authors and Affiliates
Akira Takagi 1, Masanori Matsui 2;
1 School of Medical Technology, Faculty of Health and Medical Care, Saitama Medical University, 1397-1 Yamane, Hidaka-city, Saitama 350-1241, Japan.
2 Department of Microbiology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-cho, Iruma-gun, Saitama 350-0495, Japan mmatsui@saitama-med.ac.jp.
BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes
Peiffer L., et al.
December 2020
Authors and Affiliates
Lukas Peiffer 1,2, Farnoush Farahpour 3, Ashwin Sriram 1 2, Ivelina Spassova 1, Daniel Hoffmann 3, Linda Kubat 1, Patrizia Stoitzner 4, Thilo Gambichler 5, Antje Sucker 6, Selma Ugurel 6, Dirk Schadendorf 6, Jürgen C Becker 7,8,9;
1 Deutsches Konsortium Für Translationale Krebsforschung (DKTK), Partner Site Essen, Translational Skin Cancer Research, University of Duisburg-Essen, Universitätsstr. 1, 45141, Essen, Germany.
2 Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
3 Bioinformatics and Computational Biophysics, University Duisburg-Essen, Essen, Germany.
4 Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
5 Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
6 Department of Dermatology, University Hospital of Essen, Essen, Germany.
7 Deutsches Konsortium Für Translationale Krebsforschung (DKTK), Partner Site Essen, Translational Skin Cancer Research, University of Duisburg-Essen, Universitätsstr. 1, 45141, Essen, Germany. j.becker@dkfz.de.
8 Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. j.becker@dkfz.de.
9 Department of Dermatology, University Hospital of Essen, Essen, Germany. j.becker@dkfz.de.
Diagnostic differentiation of Zika and dengue virus exposure by analyzing T cell receptor sequences from peripheral blood of infected HLA-A2 transgenic mice
Hassert M., et al.
December 2020
Authors and Affiliates
Mariah Hassert 1, Kyle J Wolf 1, Ahmad Rajeh 2, Courtney Shiebout 2, Stella G Hoft 1, Tae-Hyuk Ahn 2 3, Richard J DiPaolo 1, James D Brien 1, Amelia K Pinto 1;
1 Department of Molecular Microbiology and Immunology, Saint Louis University- School of Medicine, Saint Louis, Missouri, United States of America.
2 Program in Bioinformatics and Computational Biology, Saint Louis University, Saint Louis, Missouri, United States of America.
3 Department of Computer Science, Saint Louis University, Saint Louis, Missouri, United States of America.
Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature
Kelkka T., et al.
December 2020
Authors and Affiliates
Tiina Kelkka 1,2,3,4, Paula Savola 1,2,3,4, Dipabarna Bhattacharya 1,2,3,4, Jani Huuhtanen 1,2,3,4, Tapio Lönnberg 5, Matti Kankainen 1,2,4, Kirsi Paalanen 6, Mikko Tyster 1,2,3,4, Maija Lepistö 7, Pekka Ellonen 7, Johannes Smolander 5, Samuli Eldfors 7, Bhagwan Yadav 1,2,3,4, Sofia Khan 5, Riitta Koivuniemi 8, Christopher Sjöwall 9, Laura L. Elo 5,10, Harri Lähdesmäki 11, Yuka Maeda 12, Hiroyashi Nishikawa 12, Marjatta Leirisalo-Repo 8, Tuulikki Sokka-Isler 6,13 and Satu Mustjoki 1,2,3,4;
1 Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland
2 Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
3 Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
4 Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
5 Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
6 Rheumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
7 Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
8 Rheumatology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland
9 Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden
10 Institute of Biomedicine, University of Turku, Turku, Finland
11 Department of Computer Science, Aalto University School of Science, Espoo, Finland
12 Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan
13 University of Eastern Finland, Faculty of Health Sciences, Kuopio, Finland
Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma
Anagnostou V., et al.
December 2020
Authors and Affiliates
Valsamo Anagnostou 1,2, Daniel C Bruhm 1, Noushin Niknafs 1, James R White 1, Xiaoshan M Shao 1, John William Sidhom 1,2, Julie Stein 2,3, Hua-Ling Tsai 1, Hao Wang 1, Zineb Belcaid 1,2, Joseph Murray 1,2, Archana Balan 1, Leonardo Ferreira 1, Petra Ross-Macdonald 4, Megan Wind-Rotolo 4, Alexander S Baras 2,3, Janis Taube 2,3, Rachel Karchin 1, Robert B Scharpf 1, Catherine Grasso 5,6, Antoni Ribas 5,7, Drew M Pardoll 1,2, Suzanne L Topalian 1,2,8, Victor E Velculescu 1,2,3;
1 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
2 The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
3 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
4 Bristol-Myers Squibb, Princeton, NJ 08540, USA.
5 Jonsson Comprehensive Cancer Center at the University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
6 Cedars-Sinai Medical Center, Los Angeles, CA, USA.
7 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
8 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.