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The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse

Singhania A., et al.
Scientific Reports
January 2021
Authors and Affiliates
Akul Singhania 1, John Pham 1, Rekha Dhanwani 1, April Frazier 1, Juliana Rezende Dutra 2, Karen S Marder 2, Elizabeth Phillips 3,4, Simon Mallal 3,4, Amy W Amara 5, David G Standaert 5, David Sulzer 2,6,7, Bjoern Peters 1,8, Alessandro Sette 1,8, Cecilia S Lindestam Arlehamn 9; 1 Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA. 2 Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA. 3 Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, 6150, Australia. 4 Vanderbilt University School of Medicine, Nashville, TN, 37235, USA. 5 Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA. 6 Department of Psychiatry, Columbia University Medical Center, New York, NY, 10032, USA. 7 Department of Pharmacology, Columbia University Medical Center, New York, NY, 10032, USA. 8 Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA. 9 Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA. cecilia@lji.org.

Distinct T cell receptor repertoire diversity of clinically defined high-grade serous ovarian cancer treatment subgroups

Lee S., et al.
iScience
January 2021
Authors and Affiliates
Sanghoon Lee 1, Li Zhao 2, Latasha D. Little 2, Shannon N. Westin 3, Amir A. Jazarei 3, Nicole D. Fleming 3, Jianhua Zhang 2, P. Andrew Futreal 2, Anil K. Sood 3; 1 Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3 Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Necrotizing enterocolitis induces T lymphocyte-mediated injury in the developing mammalian brain

Zhou Q., et al.
Science Translational Medicine
January 2021
Authors and Affiliates
Qinjie Zhou 1,2, Diego F Niño 1,2, Yukihiro Yamaguchi 1,2, Sanxia Wang 1,2, William B Fulton 1,2, Hongpeng Jia 1,2, Peng Lu 1,2, Thomas Prindle Jr 1,2, David Pamies 3,4, Meaghan Morris 5, Liam L Chen 4, Chhinder P Sodhi 6,2, David J Hackam 6,2; 1 Division of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA. 2 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3 Center for Alternatives to Animal Testing, Johns Hopkins School of Public Health, Baltimore, MD, USA. 4 Department of Biomedical Science, University of Lausanne, Lausanne, Switzerland. 5 Division of Neuropathology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA. 6 Division of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children's Center, Johns Hopkins Hospital, Baltimore, MD, USA. dhackam1@jhmi.edu csodhi@jhmi.edu.

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

Yu J., et al.
Nature Medicine
January 2021
Authors and Affiliates
Jiali Yu 1,2, Michael D Green 3,4,5, Shasha Li 1,2,6, Yilun Sun 7,8, Sara N Journey 9, Jae Eun Choi 10,11, Syed Monem Rizvi 12, Angel Qin 13, Jessica J Waninger 9,11, Xueting Lang 1,2, Zoey Chopra 9, Issam El Naqa 7,14, Jiajia Zhou 1,2, Yingjie Bian 1,2, Long Jiang 2,7, Alangoya Tezel 9, Jeremy Skvarce 9, Rohan K Achar 9,15, Merna Sitto 7, Benjamin S Rosen 7, Fengyun Su 10,11, Sathiya P Narayanan 10,11, Xuhong Cao 10,11,16, Shuang Wei 1,2, Wojciech Szeliga 1,2, Linda Vatan 1,2, Charles Mayo 7, Meredith A Morgan 7, Caitlin A Schonewolf 7, Kyle Cuneo 7, Ilona Kryczek 1,2, Vincent T Ma 13, Christopher D Lao 13, Theodore S Lawrence 7, Nithya Ramnath 17,13, Fei Wen 12, Arul M Chinnaiyan 10,11,16, Marcin Cieslik 6,10,11, Ajjai Alva 2,13, Weiping Zou 18,19,20,21,22; 1 Department of Surgery, University of Michigan, Ann Arbor, MI, USA. 2 Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. 3 Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. migr@med.umich.edu. 4 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA. migr@med.umich.edu. 5 Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA. migr@med.umich.edu. 6 Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA. 7 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA. 8 Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. 9 University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA. 10 Department of Pathology, University of Michigan, Ann Arbor, MI, USA. 11 Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA. 12 Chemical Engineering, University of Michigan, Ann Arbor, MI, USA. 13 Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. 14 Machine Learning Department, Moffitt Cancer Center, Tampa, FL, USA. 15 University of Michigan School of Public Health, Ann Arbor, MI, USA. 16 Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA. 17 Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA. 18 Department of Surgery, University of Michigan, Ann Arbor, MI, USA. wzou@med.umich.edu. 19 Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. wzou@med.umich.edu. 20 Department of Pathology, University of Michigan, Ann Arbor, MI, USA. wzou@med.umich.edu. 21 Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA. wzou@med.umich.edu. 22 Graduate Program in Cancer Biology, University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA. wzou@med.umich.edu.

Image guided lymph node core needle biopsy predicts survival in mycosis fungoides and Sézary syndrome

Calvani J., et al.
British Journal of Dermatology
January 2021
Authors and Affiliates
J Calvani 1, A de Masson 2,3, C de Margerie-Mellon 4, É de Kerviler 4, C Ram-Wolff 2,3, A Gruber 3,5, V Meignin 1, P Brice 6, A Sadoux 5, S Mourah 3,5, M Bagot 2,3, Maxime Battistella 1,3; 1 Pathology Department, Assistance Publique Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France. 2 Dermatology Department, Assistance Publique Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France. 3 INSERM UMR-S976, Université de Paris, Paris, France. 4 Radiology Department, Assistance Publique Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France. 5 Solid tumor genomics Department, Assistance Publique Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France. 6 Hematology Department, Assistance Publique Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France.

Safety and efficacy of consolidation therapy with ipilimumab plus nivolumab after autologous stem cell transplantation

Skarbnik AP, et al.
January 2021
Authors and Affiliates
Alan P Skarbnik 1,2, Michele L Donato 1,3, Rena Feinman 3,4, Scott D Rowley 1,3, David H Vesole 1,3, Andre H Goy 1,3, Pashna N Munshi 3,5, Tatyana Feldman 1,3, Lori A Leslie 1,3, Noa Biran 1,3, Themba Nyirenda 1, Paul A Fields 6, Dante Descalzi-Montoya 4, Joshua Zenreich 1, Robert Korngold 3,4 and Andrew L Pecora 1,3; 1 John Theurer Cancer Center at Hackensack University Medical Center, NJ, USA 2 Novant Health Cancer Institute, NC, USA 3 Consortium Member Georgetown Lombardi Comprehensive Cancer Center 4 Center for Discovery and Innovation at Hackensack Meridian Health, NJ, US 5 Georgetown University Medical Center, DC, USA 6 Adaptive Biotechnologies, WA, USA

Broadly reactive human CD4 + T cells against Enterobacteriaceae are found in the naïve repertoire and are clonally expanded in the memory repertoire

Cassotta A., et al.
January 2021
Authors and Affiliates
Antonino Cassotta 1,2, Jérémie D Goldstein 1, Greta Durini 1, David Jarrossay 1, Franca Baggi Menozzi 3, Mario Venditti 4, Alessandro Russo 5, Marco Falcone 5, Antonio Lanzavecchia 1, Maria Cristina Gagliardi 6, Daniela Latorre 1,2, Federica Sallusto 1,2; 1 Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland. 2 Institute of Microbiology, ETH Zurich, Switzerland. 3 Servizio di Microbiologia EOLAB, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. 4 Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. 5 Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. 6 Center for Gender Specific Medicine, Istituto Superiore di Sanità, Rome, Italy.

Selection influences naive CD8+ TCRβ repertoire sharing

Yiu HH., et al.
December 2020
Authors and Affiliates
Hao H Yiu 1, Louis N Schoettle 2, Marlene Garcia-Neuer 2, Joseph N Blattman 2, Philip Lf Johnson 1; 1 Department of Biology, University of Maryland, College Park, MD, 20742, USA. 2 School of Life Sciences &, The Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.

Population variability in the generation and selection of T-cell repertoires

Sethna Z., et al.
December 2020
Authors and Affiliates
Zachary Sethna 1, Giulio Isacchini 2,3, Thomas Dupic 2, Thierry Mora 2, Aleksandra M Walczak 2, Yuval Elhanati 4; 1 Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America. 2 Laboratoire de physique de l'École Normale Supérieure, PSL University, CNRS, Sorbonne Université, Université de Paris 24 rue Lhomond, Paris, France. 3 Max Planck Institute for Dynamics and Self-organization, Am Faßberg 17, Göttingen, Germany. 4 Computational Oncology, Department of Epidemiology and Biostatistics, and Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

Mobilization of pre-existing polyclonal T cells specific to neoantigens but not self-antigens during treatment of a patient with melanoma with bempegaldesleukin and nivolumab

Veatch JR., et al.
December 2020
Authors and Affiliates
Joshua R Veatch 1, Naina Singhi 2, Brenda Jesernig 2, Kelly G Paulson 2, Jonathan Zalevsky 3, Ernesto Iaccucci 3, Scott S Tykodi 2,4, Stanley R Riddell 2; 1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA jveatch@fhcrc.org. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 3 Nektar Therapeutics, San Francisco, California, USA. 4 Department of Medical Oncology, University of Washington, Seattle, Washington, USA.
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