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Select antitumor cytotoxic CD8 + T clonotypes expand in patients with chronic lymphocytic leukemia treated with ibrutinib

Baptista MJ, et al.
Clinical Cancer Research
April 2021
Authors and Affiliates
Maria Joao Baptista 1, Sivasubramanian Baskar 2, Erika M Gaglione 3, Keyvan Keyvanfar 4, Inhye Ahn 5, Adrian Wiestner 6, Clare Sun 7; 1 Hematology Branch, National Heart Lung and Blood Institute. 2 Hematology Branch, Lymphoid Malignancies Section, National Heart, Lung and Blood Institute, National Institutes of Health. 3 Hematology Branch, NHLBI,NIH. 4 Hematology Branch, NHLBI/NIH. 5 National Heart, Lung and Blood Institute, National Institutes of Health. 6 Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health. 7 Hematology Branch, National Heart Lung and Blood Institute clare.sun@nih.gov.

Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy

Han J, et al.
March 2021
Authors and Affiliates
Jichang Han 1, Yanding Zhao 2, Keisuke Shirai 3,4, Aleksey Molodtsov 1, Fred W. Kolling 3, Jan L. Fisher 4, Peisheng Zhang 3, Shaofeng Yan 5, Tyler G. Searles 3, Justin M. Bader 3, Jiang Gui 3, Chao Cheng 6, Marc S. Ernstoff 7, Mary Jo Turk 1,3 and Christina V. Angeles 3,8,9,10; 1 Departments of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA 2 Departments of Molecular and Systems Biology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA 3 Norris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA 4 Departments of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA 5 Departments of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA 6 Baylor School of Medicine, Houston, TX, USA 7 Roswell Park Cancer Institute, Buffalo, NY, USA 8 Departments of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA 9 University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA 10 Department of Surgery, University of Michigan, Ann Arbor, MI, USA

Predicting recognition between T cell receptors and epitopes with TCRGP

Jokinen E, et al.
March 2021
Authors and Affiliates
Emmi Jokinen 1, Jani Huuhtanen 2,3, Satu Mustjoki 2,3,4, Markus Heinonen 1,5, Harri Lähdesmäki 1; 1 Department of Computer Science, Aalto University, Espoo, Finland. 2 Translational Immunology Research program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. 3 Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. 4 iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland. 5 Helsinki Institute for Information Technology, Espoo, Finland.

Recurrent Myocarditis Induced by Immune-Checkpoint Inhibitor Treatment Is Accompanied by Persistent Inflammatory Markers Despite Immunosuppressive Treatment

Aghel N, et al.
March 2021
Authors and Affiliates
Nazanin Aghel 1,2, Dakota Gustafson 3,4, Ashley Di Meo 5, Milena Music 5, Ioannis Prassas 5, Michael A. Seidman 6, Aaron R. Hansen 7, Paaladinesh Thavendiranathan 1,8, Eleftherios P. Diamandis 4,5,9,10, Diego Delgado 1 and Jason E. Fish 1,3,4; 1 Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, Ted Rogers Program in Cardiotoxicity Prevention, University Health Network, Toronto, ON, Canada 2 Division of Cardiology, Cardio-oncology Program, Juravinski Hospital, McMaster University, Hamilton, ON, Canada 3 Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada 4 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada 5 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada 6 Laboratory Medicine Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada 7 Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada 8 Joint Division of Medical Imaging, Toronto General Hospital, University Health Network, Toronto, ON, Canada 9 Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada 10 Department of Clinical Biochemistry, University Health Network, Toronto, ON, Canada

Utility of high-throughput sequencing of T-cell receptor rearrangements in assessing treatment response in patients with mature T-cell lymphoma

Phull PM, et al.
precision cancer medicine
March 2021
Authors and Affiliates
Pooja M. Phull 1, Carlyn R. Tan 1, Henry C. Fung 1, Paul A. Fields 2, Yang Liu 1, Jasmine Zain 3, Nathan H. Fowler 4, R. Katherine Alpaugh 5, Yasuhiro Ok i4, Stefan K. Barta 1,6; 1 Department of Hematology and Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA 2 Adaptive Biotechnologies, Seattle, WA, USA 3 Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Cancer Center, Duarte, CA, USA 4 Department of Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, TX, USA 5 Protocol Support Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA 6 Department of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA

Complete response to PD-1 blockade following EBV-specific T-cell therapy in metastatic nasopharyngeal carcinoma

Smith C. et al.
npj precision oncology
March 2021
Authors and Affiliates
Corey Smith 1, Margaret McGrath 2, Michelle A Neller 1, Katherine K Matthews 1, Pauline Crooks 1, Laetitia Le Texier 1, Benedict Panizza 2, Sandro Porceddu 2, Rajiv Khanna 3; 1 QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 2 Princess Alexandra Hospital, Faculty of Medicine, University of Queensland, Brisbane, Australia. 3 QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. rajiv.khanna@qimr.edu.au.