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Masato Ogishi 1,2, Rui Yang 3, Caner Aytekin 4, David Langlais 5, Mathieu Bourgey 6, Taushif Khan 7, Fatima Al Ali 7, Mahbuba Rahman 7, Ottavia M Delmonte 8, Maya Chrabieh 9,10, Peng Zhang 3, Conor Gruber 11,12,13,14, Simon J Pelham 3, András N Spaan 3, Jérémie Rosain 9,10, Wei-Te Lei 3, Scott Drutman 3, Matthew D Hellmann 15,16, Margaret K Callahan 15,16, Matthew Adamow 17,18, Phillip Wong 17, Jedd D Wolchok 15,16,18,19, Geetha Rao 20, Cindy S Ma 20,21, Yuka Nakajima 22, Tomonori Yaguchi 22, Kenji Chamoto 22, Samuel C Williams 23,24, Jean-Francois Emile 25, Flore Rozenberg 26, Michael S Glickman 27, Franck Rapaport 3, Gaspard Kerner 9,10, Garrett Allington 28,29,30, Ilhan Tezcan 31, Deniz Cagdas 31, Ferda O Hosnut 32, Figen Dogu 33, Aydan Ikinciogullari 33, V Koneti Rao 34, Leena Kainulainen 35, Vivien Béziat 3,9,10, Jacinta Bustamante 3,9,10,36, Silvia Vilarinho #,28,29,30, Richard P Lifton #,28,37, Bertrand Boisson #,3,9,10, Laurent Abel #,3,9,10, Dusan Bogunovic #,11,12,13,14, Nico Marr #,7,38, Luigi D Notarangelo #,8, Stuart G Tangye #,20,21, Tasuku Honjo #,22, Philippe Gros #,39,40, Stéphanie Boisson-Dupuis #,41,42,43, Jean-Laurent Casanova #,44,45,46,47; 1 St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. mogishi@rockefeller.edu. 2 The David Rockefeller Graduate Program, Rockefeller University, New York, NY, USA. 3 St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. 4 Department of Pediatric Immunology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey. 5 Department of Human Genetics, McGill University, Montreal, Quebec, Canada. 6 McGill University Genome Center, Montreal, Quebec, Canada. 7 Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. 8 Immune Deficiency Genetics Section, Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 9 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France. 10 University of Paris, Imagine Institute, Paris, France. 11 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 12 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 13 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 14 Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 15 Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 16 Weill Cornell Medicine, New York, NY, USA. 17 Immune Monitoring Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 18 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. 19 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 20 Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia. 21 St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia. 22 Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan. 23 Laboratory of Investigative Dermatology, Rockefeller University, New York, NY, USA. 24 Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA. 25 Department of Pathology, Assistance Publique-Hôpitaux de Paris, Ambroise Paré Hospital, Boulogne-Billancourt, France. 26 Department of Virology, Cochin Hospital, University of Paris, Paris, France. 27 Immunology Program, Sloan Kettering Institute, New York, NY, USA. 28 Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. 29 Section of Digestive Diseases, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. 30 Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. 31 Department of Pediatric Immunology, Hacettepe University Medical Faculty, Ankara, Turkey. 32 Department of Pediatric Gastroenterology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey. 33 Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey. 34 Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 35 Department of Pediatrics and Department of Medicine, Turku University Hospital, Turku, Finland. 36 Study Center of Immunodeficiencies, Necker Hospital for Sick Children, Paris, France. 37 Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA. 38 College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. 39 McGill Research Centre on Complex Traits, Montreal, Quebec, Canada. 40 Department of Biochemistry, McGill University, Montreal, Quebec, Canada. 41 St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. stbo603@rockefeller.edu. 42 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France. stbo603@rockefeller.edu. 43 University of Paris, Imagine Institute, Paris, France. stbo603@rockefeller.edu. 44 St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. casanova@rockefeller.edu. 45 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France. casanova@rockefeller.edu. 46 University of Paris, Imagine Institute, Paris, France. casanova@rockefeller.edu. 47 Howard Hughes Medical Institute, New York, NY, USA. casanova@rockefeller.edu. # Contributed equally.