Browse our 650+ Publications
Latest Publications
The molecular and phenotypic makeup of fetal human skin T lymphocytes
Reitermaier R, et al.
October 2021
Authors and Affiliates
René Reitermaier 1, Tanya Ayub 1, Julia Staller 1, Philip Kienzl 1, Nikolaus Fortelny 2, Pablo Augusto Vieyra-Garcia 3, Christof Worda 4, Christian Fiala 5 6, Clement Staud 7, Wolfgang Eppel 4, Anke Scharrer 8, Thomas Krausgruber 9, Adelheid Elbe-Bürger 1;
1 Department of Dermatology, Medical University of Vienna, Austria.
2 Department of Biosciences, University of Salzburg, Salzburg, Austria.
3 Department of Dermatology, Medical University of Graz, Graz, Austria.
4 Department of Obstetrics & Gynecology, Medical University of Vienna, Austria.
5 Gynmed Clinic, Vienna, Austria.
6 Department of Women's and Children's Health, Division of Obstetrics and Gynaecology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
7 Department of Surgery, Division of Plastic and Reconstructive Surgery, Medical University of Vienna, Austria.
8 Department of Pathology, Medical University of Vienna, Austria.
9 CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Intrathymic differentiation of natural antibody-producing plasma cells in human neonates
Cordero H, et al.
October 2021
Authors and Affiliates
Hector Cordero 1, Rodney G King 2, Pranay Dogra 1,3, Chloe Dufeu 1, Sarah B See 1, Alexander M Chong 4, Anne-Catrin Uhlemann 4, Siu-Hong Ho 1, David M Kalfa 5, Emile A Bacha 5, John F Kearney 2, Emmanuel Zorn 6;
1 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 10032, USA.
2 Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
3 Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA.
4 Division of Infectious Diseases in the College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, 10032, USA.
5 Division of Cardiac, Thoracic and Vascular Surgery, Columbia University Medical Center, New York, NY, 10032, USA.
6 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 10032, USA. ez2184@cumc.columbia.edu.
Deep learning-based prediction of the T cell receptor–antigen binding specificity
Lu T, et al.
October 2021
Authors and Affiliates
Tianshi Lu 1,6, Ze Zhang 1,6, James Zhu 1, Yunguan Wang 1, Peixin Jiang 2, Xue Xiao 1, Chantale Bernatchez 3, John V. Heymach 2, Don L. Gibbons 2, Jun Wang 4, Lin Xu 1, Alexandre Reuben 2 and Tao Wang 1,5;
1 Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
2 Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
3 Department of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
4 Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
5 Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA.
6 These authors contributed equally: Tianshi Lu, Ze Zhang
Integrated analysis toolset for defining and tracking alloreactive T-cell clones after human solid organ and hematopoietic stem cell transplantation
Obradovic A, et al.
October 2021
Authors and Affiliates
Aleksandar Obradovic a,b, Yufeng Shen b, Megan Sykes a,c,d, Jianing Fu a;
a Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, United States
b Department of Systems Biology, Columbia University, New York, NY 10032, United States
c Department of Surgery, Columbia University, New York, NY 10032, United States
d Department of Microbiology & Immunology, Columbia University, New York, NY 10032, United States
Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19
Lee JW, et al.
September 2021
Authors and Affiliates
Jihoon W Lee 1, Yapeng Su 2,3,4, Priyanka Baloni 5, Daniel Chen 5, Ana Jimena Pavlovitch-Bedzyk 6, Dan Yuan 5, Venkata R Duvvuri 5, Rachel H Ng 5, Jongchan Choi 5, Jingyi Xie 5, Rongyu Zhang 5, Kim Murray 5, Sergey Kornilov 5, Brett Smith 5, Andrew T Magis 5, Dave S B Hoon 7, Jennifer J Hadlock 5, Jason D Goldman 8,9,10, Nathan D Price 5,11, Raphael Gottardo 12,13,14, Mark M Davis 6,5,16, Leroy Hood 5,9, Philip D Greenberg 17,18, James R Heath 19,20;
1 Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
2 Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. suyapeng.tju@gmail.com.
3 Institute for Systems Biology, Seattle, WA, USA. suyapeng.tju@gmail.com.
4 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. suyapeng.tju@gmail.com.
5 Institute for Systems Biology, Seattle, WA, USA.
6 Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
7 St. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA.
8 Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, USA.
9 Providence St. Joseph Health, Renton, WA, USA.
10 Division of Allergy & Infectious Diseases, University of Washington, Seattle, WA, USA.
11 Department of Bioengineering, University of Washington, Seattle, WA, USA.
12 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
13 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
14 Department of Statistics, University of Washington, Seattle, WA, USA.
15 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
16 The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
17 Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. pgreen@uw.edu.
18 Departments of Immunology and Medicine, University of Washington, Seattle, WA, USA. pgreen@uw.edu.
19 Institute for Systems Biology, Seattle, WA, USA. jim.heath@isbscience.org.
20 Department of Bioengineering, University of Washington, Seattle, WA, USA. jim.heath@isbscience.org.
Tumor associated antigen specific T cells with nivolumab are safe and persist in vivo in rel/ref Hodgkin Lymphoma
Dave H, et al.
September 2021
Authors and Affiliates
Hema Dave 1, Madeline Terpilowski 2, Mimi Mai 3, Keri Toner 4, Melanie Grant 5, Maja Stanojevic 1, Christopher Andrew Lazarski 2, Abeer Shibli 1, Stephanie Ann Bien 6, Philp Maglo 1, Fahmida Hoq 7, Reuven Schore 4, Martha J Glenn 8, Boyu Hu 9, Patrick J Hanley 2, Richard F Ambinder 10, Catherine M Bollard 4;
1 Children's National Hospital, Washington, District of Columbia, United States.
2 Children's National Medical Center, Washington, District of Columbia, United States.
3 The George Washington school of Medicine, United States.
4 The George Washington University School of Medicine, United States.
5 Emory University School of Medicine, United States.
6 Adaptive Biotechnologies, Seattle, Washington, United States.
7 CNMC, Laytonsville, Maryland, United States.
8 University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, United States.
9 Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States.
10 Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Self-mediated positive selection of T cells sets an obstacle to the recognition of nonself
Koncz B, et al.
September 2021
Authors and Affiliates
Balázs Koncz 1, Gergő M Balogh 1, Benjamin T Papp 1,2, Leó Asztalos 1,2, Lajos Kemény 1,3,4, Máté Manczinger 5,3,4,6;
1 Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary.
2 Szeged Scientists Academy, 6720 Szeged, Hungary.
3 Magyar Tudományos Akadémia - Szegedi Tudományegyetem (MTA-SZTE) Dermatological Research Group, Eötvös Loránd Research Network (ELKH), University of Szeged, 6720 Szeged, Hungary.
4 Hungarian Centre of Excellence for Molecular Medicine - University of Szeged (HCEMM-USZ) Skin Research Group, 6720 Szeged, Hungary.
5 Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary; manczinger.mate@med.u-szeged.hu.
6 Biological Research Centre, Institute of Biochemistry, Synthetic and Systems Biology Unit, Eötvös Loránd Research Network (ELKH), 6726 Szeged, Hungary.
Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion
Lan Y, et al.
September 2021
Authors and Affiliates
Yan Lan 1, Mahmoud Moustafa 2, Maximillian Knoll 3, Chunxiao Xu 4, Jennifer Furkel 3, Adam Lazorchak 4, Tsz-Lun Yeung 4, Sayed-Mohammad Hasheminasab 5, Molly H Jenkins 4, Sarah Meister 3, Huakui Yu 4, Julian Schlegel 3, Bo Marelli 4, Zili Tang 3, Guozhong Qin 4, Carmen Klein 3, Jin Qi 4, Cheng Zhou 6, George Locke 7, Damir Krunic 8, Melissa G Derner 4, Christian Schwager 3, Rachel E Fontana 4, Katharina Kriegsmann 9, Feng Jiang 4, Katrin Rein 3, Mark Kriegsmann 10, Juergen Debus 3, Kin-Ming Lo 4, Amir Abdollahi 11;
1 Department of TIP OIO, EMD Serono Research & Development Institute, 45 Middlesex Turnpike, Billerica, MA 01821, USA; an affiliate of Merck KGaA, Darmstadt, Germany. Electronic address: yan.lan@emdserono.com.
2 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; Department of Clinical Pathology, Suez Canal University, Ismailia 41522, Egypt.
3 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany.
4 Department of TIP OIO, EMD Serono Research & Development Institute, 45 Middlesex Turnpike, Billerica, MA 01821, USA; an affiliate of Merck KGaA, Darmstadt, Germany.
5 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, Charité Universitätsmedizin, Berlin, Germany.
6 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
7 Department of Translational Medicine, EMD Serono Research & Development Institute, Billerica, MA 01821, USA; an affiliate of Merck KGaA, Darmstadt, Germany.
8 Light Microscopy Facility, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
9 Department of Hematology, Oncology, and Rheumatology, Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany.
10 Department of Pathology, Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany.
11 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. Electronic address: a.amir@dkfz.de.
Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma
Bräunlein E, et al.
September 2021
Authors and Affiliates
Eva Bräunlein 1, Gaia Lupoli 1, Franziska Füchsl 1, Esam T Abualrous 2, Niklas de Andrade Krätzig 3,4, Dario Gosmann 1, Lukas Wietbrock 5, Sebastian Lange 3,4,6, Thomas Engleitner 3,4, Huan Lan 2, Stefan Audehm 1, Manuel Effenberger 7, Melanie Boxberg 8,9, Katja Steiger 8,10,11, Yinshui Chang 1, Kai Yu 1, Cigdem Atay 1,11, Florian Bassermann 1,4,11, Wilko Weichert 8,9,10,11, Dirk H Busch 7, Roland Rad 3,4,6,11, Christian Freund 2, Iris Antes 5, Angela M Krackhardt 12,4,11;
1 Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
2 Laboratory of Protein Biochemistry, Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
3 Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
4 Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
5 TUM School of Life Sciences and Center for Integrated Protein Science Munich, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
6 Department of Medicine II, Klinikum rechts der Isar, TUM School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
7 Institute for Medical Microbiology Immunology and Hygiene, Technische Universität München, München, Germany.
8 Institute of Pathology, School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
9 MRI-TUM-Biobank at the Institute of Pathology, School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
10 Core Facility Experimental Pathology, School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany.
11 German Cancer Consortium (DKTK), partner-site Munich, and German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.
12 Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar der Technischen Universität München, München, Germany angela.krackhardt@tum.de.