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Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small cell lung cancer

Federico L, et al.
November 2021
Authors and Affiliates
L Federico 1, D J McGrail 2, S-E Bentebibel 3, C Haymaker 4, A Ravelli 3, M-A Forget 3, T Karpinets 5, P Jiang 6, A Reuben 6, M V Negrao 6, J Li 5, R Khairullah 6, J Zhang 5, A Weissferdt 7, A A Vaporciyan 8, M B Antonoff 8, G Walsh 8, S-Y Lin 2, A Futreal 5, I Wistuba 4, J Roth 8, L A Byers 6, P-O Gaudreau 9, N Uraoka 4, A F Cruz 4, H Dejima 4, R N Lazcano 4, L M Solis 4, E R Parra 4, J J Lee 10, S Swisher 8, T Cascone 6, J V Heymach 6, J Zhang 11, B Sepesi 12, D L Gibbons 13, C Bernatchez 14; 1 Therapeutics Discovery Division. 2 Department of Systems Biology. 3 Department of Melanoma Medical Oncology. 4 Department of Translational Molecular Pathology. 5 Department of Genomic Medicine. 6 Department of Thoracic and Head & Neck Medical Oncology. 7 Department of Pathology. 8 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. 9 Department of Oncology, Queens' University and the Canadian Cancer Trials Group; Kingston, Ontario, Canada. 10 Department of Biostatistics. 11 Department of Genomic Medicine; Department of Thoracic and Head & Neck Medical Oncology. Electronic address: jzhang20@mdanderson.org. 12 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. Electronic address: bsepesi@mdanderson.org. 13 Department of Thoracic and Head & Neck Medical Oncology; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. Electronic address: dlgibbon@mdanderson.org. 14 Department of Melanoma Medical Oncology. Electronic address: cbernatchez@mdanderson.org.

A Phase I, Open-Label, Dose-Escalation Study of the OX40 Agonist Ivuxolimab in Patients With Locally Advanced or Metastatic Cancers

Diad A, et al.
November 2021
Authors and Affiliates
Adi Diab 1, Omid Hamid 2, John A Thompson 3, Willeke Ros 4, Ferry A L M Eskens 5, Toshihiko Doi 6, Siwen Hu-Lieskovan 7, Samuel J Klempner 8, Bishu Ganguly 9, Catherine Fleener 10, Xiao Wang 11, Tenshang Jo 11, Ken Liao 12, Shahram Salek-Ardakani 13, Carrie Turich Taylor 9, Jeffrey Chou 14, Anthony B El-Khoueiry 15; 1 Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center adiab@mdanderson.org. 2 Research, The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate. 3 Medicine/Medical Oncology, University of Washington. 4 Netherlands Cancer Institute. 5 Department of Medical Oncology, Erasmus MC Cancer Institute. 6 Department of Experimental Therapeutics, National Cancer Center Hospital East. 7 David Geffen School of Medicine at UCLA. 8 Oncology, Massachusetts General Hospital. 9 Pfizer Inc. 10 Translational Medicine, Xencor Inc. 11 Pfizer (United States). 12 Clinical Pharmacology, Pfizer (United States). 13 Cancer Immunology Discovery, Pfizer (United States). 14 WRDM, Pfizer (United States). 15 Division of Medical Oncology, USC Norris Comprehensive Cancer Center.

An allogeneic multiple myeloma GM-CSF-secreting vaccine with lenalidomide induces long-term immunity and durable clinical responses in patients in near complete remission

Biavat L, et al.
November 2021
Authors and Affiliates
Luca Biavati 1, Carol Ann Huff 2, Anna Ferguson 3, Amy Sidorski 4, M Amanda Stevens 5, Lakshmi Rudraraju 6, Cristina Zucchinetti 1, Syed Abbas Ali 2, Philip Imus 1, Christian B Gocke 2, Rachel M Gittelman 7, Sarah Johnson 8, Catherine Sanders 9, Marissa Vignali 10, Anita Gandhi 11, Xiaobu Ye 3, Kimberly A Noonan 6, Ivan Borrello 12; 1 Oncology, Johns Hopkins Medicine. 2 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine. 3 Oncology, Johns Hopkins University. 4 Johns Hopkins University School of Medicine. 5 Hematologic Malignancies, Johns Hopkins Medicine. 6 Johns Hopkins Medicine. 7 Adaptive Biotechnologies (United States). 8 Computational Biology, Adaptive Biotechnologies (United States). 9 Business Development, Adaptive Biotechnologies (United States). 10 Adaptive Biotechnology. 11 Bristol-Myers Squibb (United States). 12 Oncology, Johns Hopkins University School of Medicine iborrell@jhmi.edu.

T cell receptor repertoires as potential diagnostic markers for patients with COVID-19

Hou X, et al.
November 2021
Authors and Affiliates
Xianliang Hou 1, Wentao Fan 2, Guangyu Wang 3, Xiaoyan Chen 4, Chune Mo 1, Yongsi Wang 2, Weiwei Gong 1, Xuyan Wen 5, Hui Chen 2, Dan He 2, Lijun Mo 6, Shaofeng Jiang 7, Minglin Ou 8, Haonan Guo 9, Hongbo Liu 10; 1 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. 2 Guangzhou Huayin Health Medical Group Co., Ltd (Guangzhou, China). 3 College of Laboratory Medicine, Guilin Medical University, Guilin, 541199, China. 4 Department of State owned Assets Management, Affiliated Hospital of Guilin Medical University, Guilin, 541001, China. 5 Department of pathology, Affiliated Hospital of Guilin Medical University, Guilin, 541001. 6 Clinical Laboratory, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199. 7 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, 541199, China. 8 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. Electronic address: minglinou@glmc.edu.cn. 9 Department of Clinical Laboratory, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, China. Electronic address: guohaonan@glmc.edu.cn. 10 Department of Laboratory Medicine, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. Electronic address: hbliu@glmc.edu.cn.

K 2P 18.1 translates T cell receptor signals into thymic regulatory T cell development

Ruck T, et al.
November 2021
Authors and Affiliates
Tobias Ruck #,1,2, Stefanie Bock #,3, Steffen Pfeuffer 4, Christina B Schroeter 4, Derya Cengiz 4,3, Paul Marciniak 4,3, Maren Lindner 3, Alexander Herrmann 4, Marie Liebmann 3, Stjepana Kovac 3, Lukas Gola 3, Leoni Rolfes 4, Marc Pawlitzki 4 3, Nils Opel 5, Tim Hahn 5, Udo Dannlowski 5, Thomas Pap 6, Felix Luessi 7, Julian A Schreiber 8,9, Bernhard Wünsch 8, Tanja Kuhlmann 10, Guiscard Seebohm 9, Björn Tackenberg 11, Patricia Seja 12, Frank Döring 13, Erhard Wischmeyer 13, Achmet Imam Chasan 14, Johannes Roth 14, Luisa Klotz 3, Gerd Meyer Zu Hörste 3, Heinz Wiendl 3, Tobias Marschall 15, Stefan Floess 16, Jochen Huehn 16, Thomas Budde 17, Tobias Bopp 18, Stefan Bittner 7, Sven G Meuth 4,3; 1 Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. tobias.ruck@med.uni-duesseldorf.de. 2 Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany. tobias.ruck@med.uni-duesseldorf.de. 3 Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany. 4 Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. 5 Institute for Translational Psychiatry, University of Münster, Münster, Germany. 6 Institute of Experimental Musculoskeletal Medicine (IMM), University of Münster, Münster, Germany. 7 Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. 8 Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany. 9 Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases (IfGH), University of Münster, Münster, Germany. 10 Institute of Neuropathology, University of Münster, Münster, Germany. 11 Department of Neurology, Philipps-University, Marburg, Germany. 12 Laboratory of Neurobiology, University of Helsinki, Helsinki, Finland. 13 Molecular Electrophysiology, Institute of Physiology and Center of Mental Health, University of Würzburg, Würzburg, Germany. 14 Institute of Immunology, University of Münster, Münster, Germany. 15 Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. 16 Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany. 17 Institute for Physiology I, University of Münster, Münster, Germany. 18 Institute of Immunology, Focus Program Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. # Contributed equally.

Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer

Liu X, et al.
November 2021
Authors and Affiliates
Xinjian Liu #,1,2, Xuhui Bao #,1, Mengjie Hu 1, Hanman Chang 1, Meng Jiao 1, Jin Cheng 3, Liyi Xie 4, Qian Huang 3, Fang Li 1, Chuan-Yuan Li 5,6,7; 1 Department of Dermatology, Duke University Medical Center, Durham, NC, USA. 2 Department of Biochemistry, Molecular Cancer Research Center, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China. 3 Molecular Diagnostic Laboratory of Cancer Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 4 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. 5 Department of Dermatology, Duke University Medical Center, Durham, NC, USA. Chuan.Li@duke.edu. 6 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA. Chuan.Li@duke.edu. 7 Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA. Chuan.Li@duke.edu. # Contributed equally.

Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma

Lie S, et al.
November 2021
Authors and Affiliates
Sixue Liu,1,14 Hannah M. Knochelmann,2,3,14 Shirley H. Lomeli,1 Aayoung Hong,1 Mary Richardson,4 Zhentao Yang,1 Raymond J. Lim,5,6 Yan Wang,1 Camelia Dumitras,5 Kostyantyn Krysan,5,7 Cynthia Timmers,8 Martin J. Romeo,9 Carsten Krieg,10 Elizabeth C. O’Quinn,9 Joshua D. Horton,12 Steve M. Dubinett,5,6,7 Chrystal M. Paulos,3,11,15 David M. Neskey,9,12,13,15 and Roger S. Lo1,6,7,15,16,*; 1 Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA 2 Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA 3 Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA 4 Department of Pathology, Medical University of South Carolina, Charleston, SC 29425, USA 5 Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA 6 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA 7 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA 8 Incyte Pharmaceuticals, Wilmington, DE 19803, USA 9 Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA 10 Department of Immunology and Microbiology, Medical University of South Carolina, Charleston, SC 29425, USA 11 Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA 12 Department of Otolaryngology – Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA 13Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA 14 These authors contributed equally 15 Senior author 16 Lead contact * Correspondence: rlo@mednet.ucla.edu

Minimal Residual Disease Dynamics after Venetoclax-Obinutuzumab Treatment: Extended Off-Treatment Follow-up From the Randomized CLL14 Study.

Al-Sawaf O, et al.
Journal of Clinical Oncology
November 2021
Authors and Affiliates
Othman Al-Sawaf, MD1,2,3; Can Zhang, PhD1; Tong Lu, PhD4; Michael Z. Liao, PhD4; Anesh Panchal, MSc5; Sandra Robrecht, PhD1; Travers Ching, PhD6; Maneesh Tandon, MBChB5; Anna-Maria Fink, MD1; Eugen Tausch, MD7; Christof Schneider, MD7; Matthias Ritgen, MD8; Sebastian Bottcher, MD ¨ 9; Karl-Anton Kreuzer, MD1; Brenda Chyla, PhD10; Dale Miles, PhD4; Clemens-Martin Wendtner, MD11; Barbara Eichhorst, MD1; Stephan Stilgenbauer, MD7,12; Yanwen Jiang, PhD4; Michael Hallek, MD1; and Kirsten Fischer, MD1 1University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, German CLL Study Group, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, Germany 2The Francis Crick Institute, London, United Kingdom 3UCL Cancer Institute, University College London, London, United Kingdom 4Genentech, San Francisco, CA 5Roche Products Ltd, Welwyn Garden City, United Kingdom 6Adaptive Biotechnologies Corp, Seattle, WA 7 Department of Internal Medicine III, Ulm University, Ulm, Germany 8Department II of Internal Medicine, University of Schleswig- Holstein, Kiel, Germany 9Clinic III, Special Hematology Laboratory, Rostock University Medical School, Rostock, Germany 10AbbVie Inc, Chicago, IL 11Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, Munich Clinic Schwabing, Munich, Germany 12Department of Internal Medicine I, Saarland University Medical Center, Homburg, Germany

AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein-specific Th1 response with a diverse TCR repertoire

Swanson PA, et al.
October 2021
Authors and Affiliates
Phillip A Swanson 2nd 1, Marcelino Padilla 1, Wesley Hoyland 1, Kelly McGlinchey 2, Paul A Fields 3, Sagida Bibi 4, Saul N Faust 5, Adrian B McDermott 1, Teresa Lambe # 6, Andrew J Pollard # 4, Nicholas M Durham # 7, Elizabeth J Kelly # 8, AstraZeneca/Oxford/VRC Study Group; 1 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 2 Discovery, Research and Early Development, Oncology R&D, AstraZeneca, Gaithersburg, MD 20878, USA. 3 Adaptive Biotechnologies, Seattle, WA 98102, USA. 4 Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford OX4 6PG, UK. 5 NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO16 6YD, UK. 6 The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK. 7 Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, MD 20878, USA. 8 Translational Medicine, Microbial Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA. # Contributed equally.

Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer

Westcott PMK, et al.
October 2021
Authors and Affiliates
Peter M. K. Westcott 1, Nathan J. Sacks 1, Jason M. Schenkel 1,2,3, Zackery A. Ely 1, Olivia Smith 1, Haley Hauck 1, Alex M. Jaeger 1, Daniel Zhang 1, Coralie M. Backlund 1, Mary C. Beytagh 1, J. J. Patten 1, Ryan Elbashir 1, George Eng 1,4, Darrell J. Irvine 1,5,6,7,8, Omer H. Yilmaz 1,4,9 and Tyler Jacks 1,9; 1 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. 2 Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA. 3 Harvard Medical School, Boston, MA, USA. 4 Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. 5 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. 6 Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. 7 Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. 8 Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. 9 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.