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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

Lan Y, et al.
September 2021
Authors and Affiliates
Yan Lan 1, Mahmoud Moustafa 2, Maximillian Knoll 3, Chunxiao Xu 4, Jennifer Furkel 3, Adam Lazorchak 4, Tsz-Lun Yeung 4, Sayed-Mohammad Hasheminasab 5, Molly H Jenkins 4, Sarah Meister 3, Huakui Yu 4, Julian Schlegel 3, Bo Marelli 4, Zili Tang 3, Guozhong Qin 4, Carmen Klein 3, Jin Qi 4, Cheng Zhou 6, George Locke 7, Damir Krunic 8, Melissa G Derner 4, Christian Schwager 3, Rachel E Fontana 4, Katharina Kriegsmann 9, Feng Jiang 4, Katrin Rein 3, Mark Kriegsmann 10, Juergen Debus 3, Kin-Ming Lo 4, Amir Abdollahi 11; 1 Department of TIP OIO, EMD Serono Research & Development Institute, 45 Middlesex Turnpike, Billerica, MA 01821, USA; an affiliate of Merck KGaA, Darmstadt, Germany. Electronic address: yan.lan@emdserono.com. 2 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; Department of Clinical Pathology, Suez Canal University, Ismailia 41522, Egypt. 3 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. 4 Department of TIP OIO, EMD Serono Research & Development Institute, 45 Middlesex Turnpike, Billerica, MA 01821, USA; an affiliate of Merck KGaA, Darmstadt, Germany. 5 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, Charité Universitätsmedizin, Berlin, Germany. 6 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. 7 Department of Translational Medicine, EMD Serono Research & Development Institute, Billerica, MA 01821, USA; an affiliate of Merck KGaA, Darmstadt, Germany. 8 Light Microscopy Facility, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. 9 Department of Hematology, Oncology, and Rheumatology, Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. 10 Department of Pathology, Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. 11 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. Electronic address: a.amir@dkfz.de.

Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma

Bräunlein E, et al.
September 2021
Authors and Affiliates
Eva Bräunlein 1, Gaia Lupoli 1, Franziska Füchsl 1, Esam T Abualrous 2, Niklas de Andrade Krätzig 3,4, Dario Gosmann 1, Lukas Wietbrock 5, Sebastian Lange 3,4,6, Thomas Engleitner 3,4, Huan Lan 2, Stefan Audehm 1, Manuel Effenberger 7, Melanie Boxberg 8,9, Katja Steiger 8,10,11, Yinshui Chang 1, Kai Yu 1, Cigdem Atay 1,11, Florian Bassermann 1,4,11, Wilko Weichert 8,9,10,11, Dirk H Busch 7, Roland Rad 3,4,6,11, Christian Freund 2, Iris Antes 5, Angela M Krackhardt 12,4,11; 1 Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 2 Laboratory of Protein Biochemistry, Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. 3 Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 4 Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 5 TUM School of Life Sciences and Center for Integrated Protein Science Munich, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 6 Department of Medicine II, Klinikum rechts der Isar, TUM School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 7 Institute for Medical Microbiology Immunology and Hygiene, Technische Universität München, München, Germany. 8 Institute of Pathology, School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 9 MRI-TUM-Biobank at the Institute of Pathology, School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 10 Core Facility Experimental Pathology, School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 11 German Cancer Consortium (DKTK), partner-site Munich, and German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany. 12 Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar der Technischen Universität München, München, Germany angela.krackhardt@tum.de.

Acute exercise increases immune responses to SARS CoV-2 in a previously infected man

Baker FL, et al.
September 2021
Authors and Affiliates
Forrest L Baker 1,2, Kyle A Smith 1, Tiffany M Zúñiga 1, Helena Batatinha 1, Grace M Niemiro 2, Charles R Pedlar 3, Shane C Burgess 4,5, Emmanuel Katsanis 2,6,5,7,8, Richard J Simpson 1,2,6,5; 1 Department of Nutritional Sciences, University of Arizona, Tucson, AZ, United States. 2 Department of Pediatrics, University of Arizona, Tucson, AZ, USA. 3 Faculty of Sport, Health and Applied Performance Science, St. Mary's University, London, United Kingdom. 4 Department of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, United States. 5 Department of Immunobiology, University of Arizona, Tucson, AZ, United States. 6 The University of Arizona Cancer Center, Tucson, AZ, USA. 7 Department of Medicine, University of Arizona, Tucson, AZ, United States. 8Department of Pathology, University of Arizona, Tucson, AZ, United States.

Simple Measurement of IgA Predicts Immunity and Mortality in Ataxia-Telangiectasia

Zielen S, et al.
Journal of Clinical Immunology
September 2021
Authors and Affiliates
Stefan Zielen 1, Ruth Pia Duecker 2, Sandra Woelke 1, Helena Donath 1, Sharhzad Bakhtiar 3, Aileen Buecker 1, Hermann Kreyenberg 3, Sabine Huenecke 3, Peter Bader 3, Nizar Mahlaoui 4, Stephan Ehl 5, Sabine M El-Helou 5,6,7, Barbara Pietrucha 8, Alessandro Plebani 9, Michiel van der Flier 10, Koen van Aerde 11, Sara S Kilic 12, Shereen M Reda 13, Larysa Kostyuchenko 14, Elizabeth McDermott 15, Nermeen Galal 16, Claudio Pignata 17, Juan Luis Santos Pérez 18, Hans-Juergen Laws 19, Tim Niehues 20, Necil Kutukculer 21, Markus G Seidel 22, Laura Marques 23, Peter Ciznar 24, John David M Edgar 25, Pere Soler-Palacín 26, Horst von Bernuth 27,28,29, Renate Krueger 27, Isabelle Meyts 30, Ulrich Baumann 31, Maria Kanariou 32, Bodo Grimbacher 5,6,33, Fabian Hauck 34, Dagmar Graf 35, Luis Ignacio Gonzalez Granado 36, Seraina Prader 37, Ismail Reisli 38, Mary Slatter 39, Carlos Rodríguez-Gallego 40, Peter D Arkwright 41, Claire Bethune 42, Elena Deripapa 43, Svetlana O Sharapova 44, Kai Lehmberg 45, E Graham Davies 46, Catharina Schuetz 47, Gerhard Kindle 5,48, Ralf Schubert 1; 1 Division of Allergology, Pulmonology and Cystic Fibrosis, Department for Children and Adolescents, Goethe University, Frankfurt, Germany. 2 Division of Allergology, Pulmonology and Cystic Fibrosis, Department for Children and Adolescents, Goethe University, Frankfurt, Germany. RuthPia.Duecker@kgu.de. 3 Division for Stem Cell Transplantation, Immunology and Intensive Care Unit, Department for Children and Adolescents, Goethe University, Frankfurt, Germany. 4 Pediatric Immunology-Hematology and Rheumatology Unit, French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Children's University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France. 5 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 6 RESIST - Cluster of Excellence 2155 To Hanover Medical School, Satellite Center Freiburg, Freiburg, Germany. 7 Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany. 8 Department of Immunology, The Children's Memorial Health Institute, Av. Dzieci Polskich 20, 04-730, Warsaw, Poland. 9 Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili di Brescia, Brescia, Italy. 10 Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. 11 Department of Pediatrics, Amalia's Children Hospital, Radboud University Medical Center, Nijmegen, the Netherlands. 12 Department of Pediatric Immunology and Rheumatology, the School of Medicine, Uludag University, Bursa, Turkey. 13 Department of Pediatrics, Children's Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 14 Center of Pediatric Immunology, Western Ukrainian Specialized Children's Medical Centre, Lviv, Ukraine. 15 Clinical Immunology and Allergy Unit, Nottingham University Hospitals, Nottingham, UK. 16 Department of Pediatrics, Cairo University Specialized Pediatric Hospital, Cairo, Egypt. 17 Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy. 18 Infectious Diseases and Immunodeficiencies Unit, Service of Pediatrics, Hospital Universitario Virgen de Las Nieves, Granada, Spain. 19 Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine University, Duesseldorf, Germany. 20 Centre for Child and Adolescent Health, Helios Klinikum Krefeld, Krefeld, Germany. 21 Faculty of Medicine, Department of Pediatric Immunology, Ege University, Izmir, Turkey. 22 Research Unit for Pediatric Hematology and Immunology, Division of Pediatric Hemato-Oncology, Department of Pediatrics and Adolescent Medicine, Medical University Graz, Graz, Austria. 23 Pediatric Department, Infectious Diseases and Immunodeficiencies Unit, Porto Hospital Center, Porto, Portugal. 24 Pediatric Department, Faculty of Medicine, Children University Hospital in Bratislava, Comenius University in Bratislava, Bratislava, Slovakia. 25 The Royal Hospitals & Queen's University, Belfast, UK. 26 Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall D'Hebron Research Institute, Hospital Universitari Vall D'Hebron, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. 27 Department of Pediatric Pneumology, Immunology and Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. 28 Department of Immunology, Labor Berlin Charité - Vivantes GmbH, Berlin, Germany. 29 Berlin Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany. 30 Department of Pediatrics, University Hospitals Leuven, and the Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. 31 Department of Paediatric Pulmonology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany. 32 Department of Immunology and Histocompatibility, Centre for Primary Immunodeficiencies, "Aghia Sophia" Children's Hospital, Athens, Greece. 33 DZIF-German Center for Infection Research, Satellite Center Freiburg, Freiburg, Germany; Centre for Integrative Biological Signalling Studies, Albert-Ludwigs University, Freiburg, Germany. 34 Department of Pediatrics, Dr. Von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany. 35 MVZ Dr. Reising-Ackermann Und Kollegen, Leipzig, Germany. 36 Primary Immunodeficiencies Unit, Pediatrics, Hospital 12 Octubre, Complutense University School of Medicine, Madrid, Spain. 37 Division of Immunology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. 38 Department of Pediatrics, Division of Pediatric Immunology and Allergy, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey. 39 Primary Immunodeficiency Group, Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Translational and Clinical Research Institute, Great North Childrens' Hospital, Newcastle University, Newcastle upon Tyne, UK. 40 Department of Immunology, Dr. Negrin University Hospital of Gran Canaria, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. 41 Lydia Becker Institute of Immunology and Inflammation, University of Manchester and Royal Manchester Children's Hospital, Manchester, UK. 42 University Hospital Plymouth NHS Trust, Plymouth, UK. 43 National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia. 44 Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk region, Minsk, Belarus. 45 Division for Pediatric Stem Cell Transplantation and Immunology, Clinic for Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 46 Great Ormond Street Hospital and UCL Great Ormond Street Institute of Child Health, London, UK. 47 Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 48 FREEZE Biobank, Center for Biobanking, Medical Center and Faculty of Medicine, University of Freiburg, Breisacher Str. 115, 79106, Freiburg, Germany.

Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor

Öjlert ÅK, et al.
Molecular Oncology
September 2021
Authors and Affiliates
Åsa Kristina Öjlert 1, Daniel Nebdal 1, Igor Snapkov 2, Vibeke Olsen 1, Joel Kidman 3,4, Victor Greiff 2, Jonathan Chee 3,4, Åslaug Helland 1,5,6; 1 Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Norway. 2 Department of Immunology, University of Oslo, Norway. 3 National Centre for Asbestos Related Diseases, Institute of Respiratory Health, University of Western Australia, Perth, WA, Australia. 4 School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia. 5 Department of Clinical Medicine, University of Oslo, Norway. 6 Department of Oncology, Oslo University Hospital, Norway.

CD4+ T cell and M2 macrophage infiltration predict dedifferentiated liposarcoma patient outcomes

Schroeder BA, et al.
Journal for ImmunoTherapy of Cancer
September 2021
Authors and Affiliates
Brett A Schroeder 1,2, Natalie A LaFranzo 3, Bonnie J LaFleur 4, Rachel M Gittelman 5, Marissa Vignali 5, Shihong Zhang 2, Kevin C Flanagan 3, Julie Rytlewski 6, Laura Riolobos 7, Brian C Schulte 8, Teresa S Kim 9, Eleanor Chen 10, Kimberly S Smythe 2, Michael J Wagner 2,11, Jose G Mantilla 12, Jean S Campbell 13, Robert H Pierce 2, Robin L Jones 14, Lee D Cranmer 15, Seth M Pollack 16,17; 1 National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 3 Cofactor Genomics, San Francisco, California, USA. 4 BIO5 Institute, University of Arizona, Tucson, Arizona, USA. 5 Adaptive Biotechnologies Corp, Seattle, Washington, USA. 6 Bristol Myers Squibb, Seattle, Washington, USA. 7 UW Medicine Cancer Vaccine Institute, University of Washington, Seattle, Washington, USA. 8 Division of Oncology, Northwestern University Department of Medicine, Chicago, Illinois, USA. 9 Department of Surgery, University of Washington, Seattle, Washington, USA. 10 Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA. 11 Division of Oncology, University of Washington, Seattle, Washington, USA. 12 Pathology, University of Washington Medical Center, Seattle, Washington, USA. 13 Sensei Bio, Boston, Massachusetts, USA. 14 Sarcoma, Royal Marsden Hospital NHS Trust, London, UK. 15 Seattle Cancer Care Alliance, Seattle, Washington, USA. 16 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Seth.pollack@northwestern.edu. 17 Division of Oncology, Northwestern University, Chicago, Illinois, USA.

SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation

Delmonte OM, et al.
Blood
September 2021
Authors and Affiliates
Ottavia M Delmonte 1, Jenna Ruth Ember Bergerson 1, Tomoki Kawai 2, Hye Sun Kuehn 3, David H McDermott 4, Irene Cortese 5, Michael T Zimmermann 6, Kerry Dobbs 7, Marita Bosticardo 7, Danielle Fink 8, Shamik Majumdar 9, Boaz Palterer 10, Francesca Pala 11, Nikita R Dsouza 12, Marie Pouzolles 13, Naomi Taylor 14, Katherine Rainsford Calvo 15, Stephen R Daley 16, Daniel S Velez 1, Anahita Agharahimi 17, Katherine Myint-Hpu 17, Lesia Dropulic 7, Jonathan J Lyons 18, Steven M Holland 4, Alexandra F Freeman 2, Rajarshi Ghosh 19, Morgan N Similuk 1, Julie E Niemela 20, Jennifer L Stoddard 1, Douglas B Kuhns 21, Raul Urrutia 22, Sergio Rosenzweig 3, Magdalena A Walkiewicz 1, Philip Murphy 23, Luigi D Notarangelo 11; 1 NIH, Bethesda, Maryland, United States. 2 NIAID, NIH, Bethesda, Maryland, United States. 3 Clinical Center, NIH, Bethesda, Maryland, United States. 4 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States. 5 National Institute of Neurological Disorders and Strokes, National Institutes of Health, bethesda, Maryland, United States. 6 Clinical And Translational Sciences Institute, Medical College of Wisconsin, United States. 7 National Institutes of Health, Bethesda, Maryland, United States. 8 SAIC-Frederick, Frederick, United States. 9 National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States. 10 University of Florence, Florence, Italy. 11 NIAID, National Institutes of Health, Bethesda, Maryland, United States. 12 Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, United States. 13 National Cancer Institute, NIH, United States. 14 Institute e Genetique Moleculaire de Montpellier, Centre National de la Recherche Scientifique, France. 15 National Institutes of Health Clinical Center, Bethesda, Maryland, United States. 16 Centre for Immunology and Infection Control, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia. 17 National Institute of Allergy and Infectious Diseases, NIH, bethesda, Maryland, United States. 18 LAD/NIAID/NIH, Bethesda, Maryland, United States. 19 NIAID/NIH, bethesda, Maryland, United States. 20 NIH Clinical Center, Bethesda, Maryland, United States. 21 Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States. 22 Department of Surgery, Medical College of Wisconsin, United States. 23 National Institutes of Health, Bethesda, United States.

HSCT corrects primary immunodeficiency and immune dysregulation in patients with POMP-related auto-inflammatory disease

Martinez CA, et al.
Blood
September 2021
Authors and Affiliates
Caridad A Martinez 1, Frederic Ebstein 2, Sarah K Nicholas 3, Marietta De Guzman 3, Lisa R Forbes 3, Ottavia M Delmonte 4, Marita Bosticardo 5, Riccardo Castagnoli 4, Robert Krance 3, Luigi D Notarangelo 6, Elke Krüger 2, Jordan S Orange 7, M Cecilia Poli 8; 1 Texas Children's Hospital, Houston, Texas, United States. 2 Universitätsmedizin Greifswald, Greifswald, Germany. 3 Texas Children´s Hospital, United States. 4 NIH, Bethesda, Maryland, United States. 5 National Institutes of Health, Bethesda, Maryland, United States. 6 NIAID, National Institutes of Health, Bethesda, Maryland, United States. 7 Columbia University, New York, New York, United States. 8 Baylor College of Medicina, United States.

The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination

Beilinson HA, et al.
Journal of Experimental Medicine
August 2021
Authors and Affiliates
Helen A Beilinson 1, Rebecca A Glynn 2,3, Anurupa Devi Yadavalli 1,4, Jianxiong Xiao 1, Elizabeth Corbett 1, Huseyin Saribasak 1, Rahul Arya 3, Charline Miot 3, Anamika Bhattacharyya 5, Jessica M Jones 5, Jagan M R Pongubala 4, Craig H Bassing 2,3, David G Schatz 1,6; 1 Department of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT. 2 Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 3 Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 4 Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, India. 5 Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC. 6 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.

Immunosequencing of the T-cell receptor repertoire reveals signatures specific for diagnosis and characterization of early Lyme disease

Greissl J, et al.
August 2021
Authors and Affiliates
Julia Greissl *,a, Mitch Pesesky *,b, Sudeb C. Dalai b,c, Alison W. Rebman d, Mark J. Soloski d, Elizabeth J. Horn e, Jennifer N. Dines b, Rachel M. Gittelman b, Thomas M. Snyder b, Ryan O. Emerson b, Edward Meeds a, Thomas Manley b, Ian M. Kaplan b, Lance Baldo b, Jonathan M. Carlson a,†, Harlan S. Robins †,b, John N. Aucott †,d; *Julia Greissl and Mitch Pesesky contributed equally to this study. † Jonathan M. Carlson, Harlan S. Robins, and John N. Aucott contributed equally to the oversight of this study. a Microsoft Research, Redmond, Washington, USA, and Cambridge, UK bAdaptive Biotechnologies, Seattle, Washington, USA c Stanford University School of Medicine, Stanford, California, USA d Lyme Disease Research Center, Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA e Lyme Disease Biobank, Portland, Oregon, USA
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