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A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires
Ceglia V, et al.
Frontiers in Immunology
January 2022
Authors and Affiliates
Valentina Ceglia 1,2,3, Erin J Kelley 4, Annalee S Boyle 4, Sandra Zurawski 1,3, Heather L Mead 4, Caroline E Harms 4, Jean-Philippe Blanck 1, Anne-Laure Flamar 1,2,3, Jung Hwa Kirschman 4, Paul Ogongo 5, Joel D Ernst 5, Yves Levy 2,3, Gerard Zurawski 1,3, John A Altin 4;
1 Baylor Institute for Immunology Research, Dallas, TX, United States.
2 Université Paris-Est Créteil, Sciences de la Vie et de la Santé, Créteil, France.
3 Vaccine Research Institute, INSERM, Unité U955, Institut Mondor de Recherche Biomédicale, Créteil, France.
4 Translational Genomics Research Institute, Flagstaff, AZ, United States.
5 Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, San Francisco, CA, United States.
Positive and negative selection shape the human naïve B cell repertoire
Chen JW, et al.
Journal of Clinical Investigation
January 2022
Authors and Affiliates
Jeff W Chen 1, Jean-Nicolas Schickel 1, Nikolaos Tsakiris 1, Joel Sng 1, Florent Arbogast 1, Delphine Bouis 1, Daniele Parisi 1, Ruchi Gera 1, Joshua M Boeckers 1, Fabien R Delmotte 1, Margaret Veselits 2, Catharina Schuetz 3, Eva-Maria Jacobsen 3, Carsten Posovszky 3, Ansgar S Schulz 3, Klaus Schwarz 3, Marcus R Clark 2, Laurence Menard 1, Eric Meffre 1;
1 Department of Immunobiology, Yale University, New Haven, United States of America.
2 Department of Medicine, University of Chicago, Chicago, United States of America.
3 Department of Pediatrics and Adolescent Medicine, Ulm University, Ulm, Germany.
Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Mills BN, et al.
Clinical Cancer Research
January 2022
Authors and Affiliates
Bradley N Mills 1, Haoming Qiu 2,3, Michael G Drage 4, Chunmo Chen 4, Jocelyn S Mathew 1, Jesse Garrett-Larsen 1, Jian Ye 1, Taylor P Uccello 5, Joseph D Murphy 5, Brian A Belt 1, Edith M Lord 3,5, Alan W Katz 2,3, David C Linehan 1,3, Scott A Gerber 6,3,5;
1 Department of Surgery, University of Rochester Medical Center, Rochester, New York.
2 Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York.
3 Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York.
4 Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.
5 Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
6 Department of Surgery, University of Rochester Medical Center, Rochester, New York. scott_gerber@urmc.rochester.edu.
Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids
Meng Q, et al.
Journal for ImmunoTherapy of Cancer
January 2022
Authors and Affiliates
Qingda Meng #,1, Shanshan Xie #,1, G Kenneth Gray 2, Mohammad H Dezfulian 3, Weilin Li 1, Ling Huang 1, Dipikaa Akshinthala 1, Elizabeth Ferrer 1, Catherine Conahan 1, Sofia Perea Del Pino 1, Joseph Grossman 1, Stephen J Elledge 3, Manuel Hidalgo 4, Senthil K Muthuswamy 5;
1 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
2 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
3 Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
4 Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, New York, USA smuthusw@bidmc.harvard.edu mah4006@med.cornell.edu.
5 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA smuthusw@bidmc.harvard.edu mah4006@med.cornell.edu.
# Contributed equally.
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer
Chen M, et al.
Nature Communications
January 2022
Authors and Affiliates
Ming Chen #,1,2,3,4, Runzhe Chen #,5,6,7, Ying Jin #,8,9,10, Jun Li #,7, Xin Hu #,7, Jiexin Zhang #,11, Junya Fujimoto 12, Shawna M Hubert 6,7, Carl M Gay 6, Bo Zhu 6,7, Yanhua Tian 6,7, Nicholas McGranahan 13, Won-Chul Lee 7, Julie George 14 15, Xiao Hu 8,9,10, Yamei Chen 8,9,10, Meijuan Wu 8,9,10, Carmen Behrens 6, Chi-Wan Chow 12, Hoa H N Pham 16, Junya Fukuoka 16, Jia Wu 17, Edwin Roger Parra 12, Latasha D Little 7, Curtis Gumbs 7, Xingzhi Song 7, Chang-Jiun Wu 7, Lixia Diao 11, Qi Wang 11, Robert Cardnell 6, Jianhua Zhang 7, Jing Wang 11, Xiuning Le 6, Don L Gibbons 6, John V Heymach 6, J Jack Lee 18, William N William Jr 6, Chao Cheng 19, Bonnie Glisson 6, Ignacio Wistuba 12, P Andrew Futreal 7, Roman K Thomas 20,21,22, Alexandre Reuben 23, Lauren A Byers 24, Jianjun Zhang 25,26;
1 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China. chenming@sysucc.org.cn.
2 The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, 310022, China. chenming@sysucc.org.cn.
3 Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China. chenming@sysucc.org.cn.
4 Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang, 310022, China. chenming@sysucc.org.cn.
5 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
6 Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
7 Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
8 The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, 310022, China.
9 Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
10 Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang, 310022, China.
11 Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
12 Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
13 Cancer Research United Kingdom-University College London Lung Cancer Centre of Excellence, London, WC1E6BT, UK.
14 Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, 50931, Germany.
15 Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Cologne, 50937, Cologne, Germany.
16 Department of Pathology, Nagasaki University Graduate school of Biomedical Sciences, Nagasaki, Japan.
17 Department of Image Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
18 Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
19 Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, 77030, USA.
20 Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, 50931, Germany. roman.thomas@uni-koeln.de.
21 Department of Pathology, Medical Faculty, University Hospital Cologne, Cologne, 50931, Germany. roman.thomas@uni-koeln.de.
22 DKFZ, German Cancer Research Center and German Cancer Consortium (DKTK), Heidelberg, 69115, Germany. roman.thomas@uni-koeln.de.
23 Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. areuben@mdanderson.org.
24 Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. lbyers@mdanderson.org.
25 Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. jzhang20@mdanderson.org.
26 Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. jzhang20@mdanderson.org.
# Contributed equally.
Humoral and T-Cell Responses to SARS-CoV-2 Vaccination in Multiple Sclerosis Patients Treated with Ocrelizumab
Katz JD, et al.
January 2022
Authors and Affiliates
Katz J.D.,1 Bouley A.J., 1 Jungquist R.M., 1 Douglas E.A., 1 O’Shea I.L., 1 Lathi E.S. 1;
1 The Elliot Lewis Center for Multiple Sclerosis Care, Wellesley, MA, USA
A simple assay to quantify mycobacterial lipid antigen-specific T cell receptors in human tissues and blood
Zhou AX, et al.
January 2022
Authors and Affiliates
Angela X Zhou 1,2, Thomas J Scriba 3, Cheryl L Day 4, Deanna A Hagge 5, Chetan Seshadri 1,2;
1 Department of Medicine, University of Washington, Seattle, Washington, United States of America.
2 Tuberculosis Research and Training Center, University of Washington, Seattle, Washington, United States of America.
3 South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
4 Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
5 Mycobacterial Research Laboratories, Anandaban Hospital, Kathmandu, Nepal.
Epstein-Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report
Aran A, et al.
Frontiers in Immunology
January 2022
Authors and Affiliates
Andrea Aran 1, Vicente Peg 2, Rosa Maria Rabanal 3, Cristina Bernadó 4, Esther Zamora 5, Elisa Molina 1, Yago A Arribas 1, Joaquín Arribas 4,6,7,8, José Pérez 9, Carme Roura-Mir 1, Montserrat Carrascal 10, Javier Cortés 5 9, Mercè Martí 1;
1 Immunology Unit, Department of Cell Biology, Physiology and Immunology, Institut de Biotecnologia i Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
2 Translational Molecular Pathology, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain.
3 Unitat de Patologia Murina i Comparada, Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
4 Preclinical and Translational Research Program, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
5 Breast Cancer Unit, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Barcelona, Spain.
6 Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
7 Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.
8 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
9 International Breast Cancer Center (BCC), Quironsalud Group, Barcelona, Spain.
10 Biological and Environmental Proteomics, Institute of Biomedical Research of Barcelona, Spanish National Research Council, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IIBB-CSIC/IDIBAPS), Barcelona, Spain.
Impact of T Cell Repertoire Diversity on Mortality Following Cord Blood Transplantation
Milano F, et al.
Frontiers in Immunology
January 2022
Authors and Affiliates
F Milano 1,2, R O Emerson 3, R Salit 1,2, K A Guthrie 1, L A Thur 1, A Dahlberg 1,4, H S Robins 1,3, C Delaney 1,4;
1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
2 Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States.
3 Adaptive Biotechnologies, Seattle, WA, United States.
4 Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States.