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Phase 1 TRANSCEND CLL 004 study of lisocabtagene maraleucel in patients with relapsed/refractory CLL or SLL.
Siddiqi T, et al.
Blood
March 2022
Authors and Affiliates
Tanya Siddiqi,1 Jacob D. Soumerai,2 Kathleen A. Dorritie,3 Deborah M. Stephens,4 Peter A. Riedell,5 Jon Arnason,6 Thomas J. Kipps,7 Heidi H. Gillenwater,8 Lucy Gong,8 Lin Yang,8 Ken Ogasawara,9 Jerill Thorpe,8 and William G. Wierda10
1Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA; 2Department of Medicine, Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA, USA; 3 Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; 4Internal Medicine/Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; 5Hematopoietic Cellular Therapy Program, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA; 6Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 7Moores Cancer Center, Evelyn and Edwin Tasch Chair in Cancer Research, University of California San Diego, San Diego, CA, USA; 8Bristol Myers Squibb, Seattle, WA, USA; 9Bristol Myers Squibb, Princeton, NJ, USA; and 10Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Understanding T-cell responses to COVID-19 is essential for informing public health strategies
S. Vardhana, et al.
Science Immunology
March 2022
Authors and Affiliates
Santosha Vardhana, Lance Baldo, William G. Moriceii, and E. John Wherry
An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia
Geron I, et al.
Nature Communications
March 2022
Authors and Affiliates
Ifat Geron #,1,2,3, Angela Maria Savino #,1,2,3, Hila Fishman 1,2,3, Noa Tal 1,2, John Brown 4, Virginia A Turati 4, Chela James 4, Jolanda Sarno 5, Michal Hameiri-Grossman 3, Yu Nee Lee 1,6, Avigail Rein 1,2,3, Hillary Maniriho 1,3, Yehudit Birger 1,2,3, Anna Zemlyansky 3, Inna Muler 2, Kara L Davis 5, Victoria Marcu-Malina 7, Nicole Mattson 8, Oren Parnas 9, Rabea Wagener 10, Ute Fischer 10, João T Barata 11, Catriona H M Jamieson 12, Markus Müschen 8, Chun-Wei Chen 8, Arndt Borkhardt 10, Ilan Richard Kirsch 13, Arnon Nagler 1,14, Tariq Enver 4, Shai Izraeli 15,16,17,18;
1 Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.
2 Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel.
3 The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
4 Department of Cancer Biology, UCL Cancer Institute, UCL, London, UK.
5 Department of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, CA, USA.
6 Pediatric Department and the Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital Sheba Medical Center, Tel-Hashomer, Israel.
7 Cytogenetic Unit laboratory of Hematology, Chaim Sheba Medical Center Tel Hashomer, Tel Hashomer, Israel.
8 Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA.
9 The Concern Foundation Laboratories at the Lautenberg Center for immunology and Cancer Research, IMRIC, Hebrew University Faculty of Medicine, Jerusalem, Israel.
10 Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
11 Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
12 UC San Diego, Moores Cancer Center, Division of Regenerative Medicine, Department of Medicine and Sanford Stem Cell Clinical Center, Ja Jolla, CA, USA.
13 Adaptive Biotechnologies, Inc., Seattle, WA, USA.
14 Hematology Division BMT and Cord Blood Bank Chaim Sheba Medical Center Tel-Hashomer, Tel-Hashomer, Israel.
15 Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel. sizraeli@gmail.com.
16 Institute of Pediatric Research, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer, Israel. sizraeli@gmail.com.
17 The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children's Medical Center of Israel, Petach Tikva, Israel. sizraeli@gmail.com.
18 Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA. sizraeli@gmail.com.
# Contributed equally
Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia
Bhattacharya D, et al.
Blood Cancer Journal
March 2022
Authors and Affiliates
Dipabarna Bhattacharya #,1,2, Antonella Teramo #,3, Vanessa Rebecca Gasparini #,3, Jani Huuhtanen #,1,2,4, Daehong Kim 1,2, Jason Theodoropoulos 1,2,4, Gianluca Schiavoni 5, Gregorio Barilà 3, Cristina Vicenzetto 3, Giulia Calabretto 3, Monica Facco 3, Toru Kawakami 6, Hideyuki Nakazawa 6, Brunangelo Falini 5, Enrico Tiacci 5, Fumihiro Ishida 7, Gianpietro Semenzato 3, Tiina Kelkka 1,2, Renato Zambello 3, Satu Mustjoki 8,9,10;
1 Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
2 Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
3 Department of Medicine, Hematology and Clinical Immunology Branch, University of Padova and Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.
4 Department of Computer Science, Aalto University, Espoo, Finland.
5 Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
6 Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine, Matsumoto, Japan.
7 Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine, Matsumoto, Japan.
8 Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. satu.mustjoki@helsinki.fi.
9 Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi.
10 iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland. satu.mustjoki@helsinki.fi.
# Contributed equally.
Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate
Lagattuta KA, et al.
Nature Immunology
March 2022
Authors and Affiliates
Kaitlyn A Lagattuta 1,2,3,4,5, Joyce B Kang 1,2,3,4,5, Aparna Nathan 1,2,3,4,5, Kristen E Pauken 6,7, Anna Helena Jonsson 3, Deepak A Rao 3, Arlene H Sharpe 5,6,7, Kazuyoshi Ishigaki #,8,9,10,11, Soumya Raychaudhuri #,12,13,14,15,16,17;
1 Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
2 Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
3 Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
4 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
5 Broad Institute of MIT and Harvard, Cambridge, MA, USA.
6 Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
7 Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
8 Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. kazuyoshi.ishigaki@riken.jp.
9 Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. kazuyoshi.ishigaki@riken.jp.
10 Broad Institute of MIT and Harvard, Cambridge, MA, USA. kazuyoshi.ishigaki@riken.jp.
11 Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. kazuyoshi.ishigaki@riken.jp.
12 Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. soumya@broadinstitute.org.
13 Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
14 Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
15 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
16 Broad Institute of MIT and Harvard, Cambridge, MA, USA. soumya@broadinstitute.org.
17 Centre for Genetics and Genomics Versus Arthritis, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. soumya@broadinstitute.org.
# Contributed equally.
Lack of association between pandemic chilblains and SARS-CoV-2 infection
Gehlhausen JR, et al.
PNAS
March 2022
Authors and Affiliates
Jeff R Gehlhausen 1, Alicia J Little 1, Christine J Ko 1,2, Marc Emmenegger 3, Carolina Lucas 4, Patrick Wong 4, Jon Klein 4, Peiwen Lu 4, Tianyang Mao 4, Jillian Jaycox 4, Eric Wang 4, Yale IMPACT Team; Nelson Ugwu 1, Cate Muenker 5, Dilgash Mekael 1, Rhonda Q Klein 1,6, Robert Patrignelli 7, Richard Antaya 1, Jennifer McNiff 1,2, William Damsky 1,2, Kathy Kamath 8, John Shon 8, Aaron M Ring 4, Inci Yildirim 5,9,10, Saad Omer 5,9,11, Albert I Ko 5,11, Adriano Aguzzi 3, Akiko Iwasaki 12,4,13,14;
1 Yale Department of Dermatology, Yale University, New Haven, CT 06510.
2 Yale Department of Pathology, Yale University, New Haven, CT 06510.
3 Institute of Neuropathology, University Hospital of Zürich, 8091 Zürich, Switzerland.
4 Yale Department of Immunobiology, Yale University, New Haven, CT 06510.
5 Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510.
6 Modern Dermatology, Westport, CT 06880.
7 Patrignelli Dermatology Private Practice, Trumbull, CT 06611.
8 Serimmune, Inc., Santa Barbara, CA 93117.
9 Yale Institute for Global Health, Yale University, New Haven, CT 06510.
10 Department of Pediatrics, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06510.
11 Yale Department Medicine, Section of Infectious Diseases, Yale University, New Haven, CT 06510.
12 Yale Department of Dermatology, Yale University, New Haven, CT 06510; akiko.iwasaki@yale.edu.
13 Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06510.
14 HHMI, Chevy Chase, MD 20815.
Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Sacco K, et al.
Nature Medicine
February 2022
Authors and Affiliates
Keith Sacco #,1, Riccardo Castagnoli #,1,2, Svetlana Vakkilainen #,1, Can Liu #,3,4, Ottavia M Delmonte 1, Cihan Oguz 5,6, Ian M Kaplan 7, Sara Alehashemi 1, Peter D Burbelo 8, Farzana Bhuyan 1, Adriana A de Jesus 1, Kerry Dobbs 1, Lindsey B Rosen 1, Aristine Cheng 1, Elana Shaw 1, Mikko S Vakkilainen 9, Francesca Pala 1, Justin Lack 3,5, Yu Zhang 1, Danielle L Fink 10, Vasileios Oikonomou 1, Andrew L Snow 11, Clifton L Dalgard 12,13, Jinguo Chen 14, Brian A Sellers 14, Gina A Montealegre Sanchez 15, Karyl Barron 16, Emma Rey-Jurado 17, Cecilia Vial 17, Maria Cecilia Poli 17,18, Amelia Licari 2, Daniela Montagna 2,19, Gian Luigi Marseglia 2, Francesco Licciardi 20, Ugo Ramenghi 20, Valentina Discepolo 21, Andrea Lo Vecchio 21, Alfredo Guarino 21, Eli M Eisenstein 22, Luisa Imberti 23, Alessandra Sottini 23, Andrea Biondi 24, Sayonara Mató 25, Dana Gerstbacher 26, Meng Truong 1, Michael A Stack 1, Mary Magliocco 27, Marita Bosticardo 1, Tomoki Kawai 1, Jeffrey J Danielson 1, Tyler Hulett 28, Manor Askenazi 28, Shaohui Hu 28, NIAID Immune Response to COVID Group; Chile MIS-C Group; Pavia Pediatric COVID-19 Group; Jeffrey I Cohen 29, Helen C Su 1, Douglas B Kuhns 10, Michail S Lionakis 1, Thomas M Snyder 7, Steven M Holland 1, Raphaela Goldbach-Mansky 1, John S Tsang 3 30, Luigi D Notarangelo 31;
1 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
2 Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
3 Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
4 Graduate Program in Biological Sciences, University of Maryland, College Park, MD, USA.
5 NIAID Collaborative Bioinformatics Resource (NCBR), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
6 Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA.
7 Adaptive Biotechnologies, Seattle, WA, USA.
8 National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
9 Department of Computer Science, Aalto University, Helsinki, Finland.
10 Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
11 Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
12 Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
13 The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
14 Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), National Institutes of Health, Bethesda, MD, USA.
15 Intramural Clinical Management and Operation Branch (ICMOB), Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
16 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
17 Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
18 Unidad de Inmunología y Reumatología, Hospital de niños Dr. Roberto del Río, Santiago, Chile.
19 Laboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
20 Department of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, University of Turin, Turin, Italy.
21 Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Napoli, Italy.
22 Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.
23 CREA Laboratory (AIL Center for Hemato-Oncologic Research), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.
24 Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN, University of Milano Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy.
25 Randall Children's Hospital at Legacy Emanuel, Portland, OR, USA.
26 Division of Pediatric Rheumatology, Stanford Children's Hospital, Stanford, CA, USA.
27 Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
28 CDI Laboratories, Antygen Division, Baltimore, MD, USA.
29 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
30 NIH Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
31 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. luigi.notarangelo2@nih.gov.
# Contributed equally.
Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case
Vannelle KM, et al.
Frontiers in Immunology
February 2022
Authors and Affiliates
Kevin M Vannella 1,2, Cihan Oguz 3,4, Sydney R Stein 1,2, Stefania Pittaluga 5, Esra Dikoglu 5, Arjun Kanwal 6, Sabrina C Ramelli 7, Thomas Briese 8, Ling Su 9, Xiaolin Wu 9, Marcos J Ramos-Benitez 1,2,10, Luis J Perez-Valencia 1,2, Ashley Babyak 1,2, Nu Ri Cha 11, Joon-Yong Chung 5, Kris Ylaya 5, Ronson J Madathil 12, Kapil K Saharia 13, Thomas M Scalea 14, Quincy K Tran 15, Daniel L Herr 16, David E Kleiner 5, Stephen M Hewitt 5, Luigi D Notarangelo 17, Alison Grazioli 18, Daniel S Chertow 1,2;
1 Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
2 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
3 National Institute of Allergy and Infectious Diseases Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.
4 Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.
5 Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
6 Division of Cardiology, Westchester Medical Center, Valhalla, NY, United States.
7 Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
8 Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, United States.
9 Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.
10 Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, United States.
11 Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
12 Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
13 Department of Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, MD, United States.
14 Department of Surgery, Program in Trauma, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States.
15 Department of Emergency Medicine, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States.
16 Department of Medicine, Program in Trauma, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States.
17 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
18 Kidney Diseases Branch, Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Activation and expansion of T-follicular helper cells in chronic lymphocytic leukemia nurselike cell co-cultures
Vaca AM, et al.
February 2022
Authors and Affiliates
Alicia M Vaca 1, Nikolaos Ioannou 2, Mariela Sivina 1, Elisavet Vlachonikola 3, Karen Clise-Dwyer 4, Ekaterina Kim 1, Dan Li 4, Qing Ma 4, Alessandra Ferrajoli 1, Zeev Estrov 1, William G Wierda 1, Piers E M Patten 2, Alan G Ramsay 2, Jan A Burger 5;
1 Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
2 School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
3 Institute of Applied Biosciences, Center for Research and Technology Hellas, Thessaloniki, Greece.
4 Department of Stem Cell Transplantation and Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
5 Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jaburger@mdanderson.org.