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Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage
Wang G, et al.
Genes & Genomics
May 2022
Authors and Affiliates
Guangyu Wang #,1, Yongsi Wang #,2, Shaofeng Jiang #,3, Wentao Fan 2, Chune Mo 1, Weiwei Gong 1, Hui Chen 2, Dan He 2, Jinqing Huang 3, Minglin Ou 4,5, Xianliang Hou 6;
1 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China.
2 Guangzhou Huayin Health Medical Group Co., Ltd, Guangzhou, China.
3 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, 541199, Guangxi, China.
4 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. minglinou@glmc.edu.cn.
5 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, 541199, Guangxi, China. minglinou@glmc.edu.cn.
6 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. houxianliang@zju.edu.cn.
# Contributed equally.
Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy
Towlerton AMH, et al.
Frontiers in Immunology
May 2022
Authors and Affiliates
Andrea M H Towlerton 1, Shashidhar Ravishankar 1, David G Coffey 1,2,3, Camille E Puronen 1,2, Edus H Warren 1,2;
1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
2 Division of Medical Oncology, University of Washington, Seattle, WA, United States.
3 Division of Hematology, University of Miami, Miami, FL, United States.
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
Narayan V, et al.
Nature Medicine
May 2022
Authors and Affiliates
Vivek Narayan 1,2, Julie S Barber-Rotenberg 3, In-Young Jung #,2,3,4, Simon F Lacey #,3,5, Andrew J Rech #,2,3,5,6, Megan M Davis #,3, Wei-Ting Hwang 7, Priti Lal 2,5, Erica L Carpenter 2,6, Shannon L Maude 8,9, Gabriela Plesa 3, Neha Vapiwala 1,2, Anne Chew 3, Michael Moniak 3, Ronnie A Sebro 2,10, Michael D Farwell 2,10, Amy Marshall 3, Joan Gilmore 3, Lester Lledo 3, Karen Dengel 3, Sarah E Church 11, Tyler D Hether 11, Jun Xu 3, Mercy Gohil 3, Thomas H Buckingham 2,6, Stephanie S Yee 2,6, Vanessa E Gonzalez 3, Irina Kulikovskaya 3, Fang Chen 3, Lifeng Tian 3, Kyle Tien 2,6, Whitney Gladney 3, Christopher L Nobles 4, Hayley E Raymond 4, Prostate Cancer Cellular Therapy Program Investigators; Elizabeth O Hexner 1,2,3, Donald L Siegel 3,5, Frederic D Bushman 4, Carl H June #,12,13,14,15, Joseph A Fraietta #,16,17,18,19,20, Naomi B Haas #,21,22;
1 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
2 Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
3 Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
4 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
5 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
6 Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.
7 Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
8 Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
9 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
10 Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
11 NanoString Technologies, Inc., Seattle, WA, USA.
12 Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.
13 Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.
14 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.
15 Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. cjune@upenn.edu.
16 Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu.
17 Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu.
18 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu.
19 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu.
20 Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. jfrai@upenn.edu.
21 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. naomi.haas@pennmedicine.upenn.edu.
22 Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. naomi.haas@pennmedicine.upenn.edu.
# Contributed equally.
Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients
Capelle CM, et al.
Cell Reports Medicine
May 2022
Authors and Affiliates
Christophe M Capelle 1,2, Séverine Ciré 1, Olivia Domingues 1, Isabelle Ernens 3, Fanny Hedin 4, Aurélie Fischer 3, Chantal J Snoeck 1, Wim Ammerlaan 5, Maria Konstantinou 4, Kamil Grzyb 6, Alexander Skupin 6,7, Cara L Carty 8, Christiane Hilger 1, Georges Gilson 9, Aljosa Celebic 10, Paul Wilmes 2,6, Antonio Del Sol 6,11,12, Ian M Kaplan 8, Fay Betsou 5,13, Tamir Abdelrahman 13, Antonio Cosma 4, Michel Vaillant 10, Guy Fagherazzi 3, Markus Ollert 1,14, Feng Q Hefeng 1;
1 Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
2 Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
3 Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.
4 National Cytometry Platform, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
5 Integrated BioBank of Luxembourg (IBBL), Dudelange, Luxembourg.
6 Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg.
7 Department of Neuroscience, University California San Diego, La Jolla, CA, USA.
8 Adaptive Biotechnologies, Seattle, WA, USA.
9 Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.
10 Translational Medicine Operations Hub, Competence Centre for Methodology and Statistics, Luxembourg Institute of Health, Strassen, Luxembourg.
11 CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.
12 IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
13 Laboratoire National de Santé (LNS), Dudelange, Luxembourg.
14 Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), University of Southern Denmark, Odense, Denmark.
A Phase 1/2 Trial Combining Avelumab and Trabectedin for Advanced Liposarcoma and Leiomyosarcoma
Wagner MJ, et al.
Clinical Cancer Research
May 2022
Authors and Affiliates
Michael J Wagner 1, Yuzheng Zhang 2, Lee D Cranmer 1, Elizabeth T Loggers, Graeme Black 3, Sabrina McDonnell 4, Shannon Maxwell 5, Rylee Johnson 5, Roxanne Moore 1, Pedro Hermida de Viveiros 6, Lauri Aicher 4, Kimberly S Smythe 4, Qianchuan He 3, Robin L Jones 7, Seth M Pollack 6;
1 University of Washington, Seattle, WA, United States.
2 Fred Hutchinson Cancer Research Center, Seattle, United States.
3 Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
4 Fred Hutchinson Cancer Research Center, Seattle, Washington, United States.
5 Seattle Cancer Care Alliance, Seattle, United States.
6 Northwestern University, Chicago, IL, United States.
7Royal Marsden Hospital / Institute of Cancer Research, London, Chelsea, United Kingdom.
The T-Cell Response to SARS-CoV-2 Vaccination in Inflammatory Bowel Disease is Augmented with Anti-TNF Therapy
Li D, et al.
Inflamm Bowel Dis
May 2022
Authors and Affiliates
Dalin Li 1, Alexander Xu 2, Emebet Mengesha 1, Rebecca Elyanow 3, Rachel M Gittelman 3, Heidi Chapman 3, John C Prostko 4, Edwin C Frias 4, James L Stewart 4, Valeriya Pozdnyakova 1, Philip Debbas 1, Angela Mujukian 1, Arash A Horizon 5, Noah Merin 2, Sandy Joung 6, Gregory J Botwin 1, Kimia Sobhani 7, Jane C Figueiredo 2, Susan Cheng 6, Ian M Kaplan 2, Dermot P B McGovern 1, Akil Merchant 2, Gil Y Melmed 1, Jonathan Braun 1,7;
1 *F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
2 Cedars Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
3 Adaptive Biotechnologies, Seattle, WA, USA.
4 Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL.
5 Center for Rheumatology Medical Group, Los Angeles, CA, USA.
6 Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
7 Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Bruton’s Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis
Bonami RH, et al.
Frontiers in Immunology
May 2022
Authors and Affiliates
Rachel H Bonami 1,2,3, Christina E Thurman 4, Sonam Verma 5, Camille S Westlake 4, Lindsay E Nyhoff 4, Bridgette B Barron 4, Andrea Reboldi 6, Peggy L Kendall 2,3,4,5;
1 Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
2 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
3 Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4), Nashville, TN, United States.
4 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, United States.
5 Department of Medicine, Division of Allergy and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
6 Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Neoantigen-specific CD4 + T cells in human melanoma have diverse differentiation states and correlate with CD8 + T cell, macrophage, and B cell function
Veatch JR, et al.
Cancer Cell
May 2022
Authors and Affiliates
Joshua R Veatch 1, Sylvia M Lee 2, Carolyn Shasha 3, Naina Singhi 3, Julia L Szeto 3, Ata S Moshiri 4, Teresa S Kim 5, Kimberly Smythe 3, Paul Kong 3, Matthew Fitzgibbon 3, Brenda Jesernig 3, Shailender Bhatia 2, Scott S Tykodi 2, Evan T Hall 2, David R Byrd 5, John A Thompson 2, Venu G Pillarisetty 5, Thomas Duhen 6, A McGarry Houghton 3, Evan Newell 3, Raphael Gottardo 3, Stanley R Riddell 3;
1 Department of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: jveatch@fredhutch.org.
2 Department of Medical Oncology, University of Washington, Seattle, WA, USA.
3 Department of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
4 Department of Dermatology, University of Washington, Seattle, WA, USA.
5 Department of Surgery, University of Washington, Seattle, WA, USA.
6 Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8 + T-cell large granular lymphocytic leukemia
Huuhtanen J, et al.
Nature Communications
May 2022
Authors and Affiliates
Jani Huuhtanen #,1,2,3, Dipabarna Bhattacharya #,1,2, Tapio Lönnberg 4,5, Matti Kankainen 1,2, Cassandra Kerr 6, Jason Theodoropoulos 1,2,3, Hanna Rajala 1,2, Carmelo Gurnari 6, Tiina Kasanen 1,2, Till Braun 7, Antonella Teramo 8,9, Renato Zambello 8,9, Marco Herling 7,10, Fumihiro Ishida 11,12, Toru Kawakami 11,12, Marko Salmi 5,13, Thomas Loughran 14, Jaroslaw P Maciejewski 6, Harri Lähdesmäki 3, Tiina Kelkka 1,2, Satu Mustjoki 15,16,17;
1 Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
2 Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
3 Department of Computer Science, Aalto University, Espoo, Finland.
4Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
5 InFlames Flagship Center, University of Turku, Turku, Finland.
6 Translational Hematology and Oncology Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
7 Department I of Internal Medicine, Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, University of Cologne (UoC), Cologne, Germany.
8 Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine, Padova, Italy.
9 Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.
10 Clinic of Hematology and Cellular Therapy, University of Leipzig, Leipzig, Germany.
11 Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine, Matsumoto, Japan.
12 Division of Hematology, Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
13 MediCity Research Laboratory and Institute of Biomedicine, University of Turku, Turku, Finland.
14 Division of Hematology/Oncology, Department of Medicine, UVA Cancer Center, University of Virginia, Charlottesville, VA, USA.
15 Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. satu.mustjoki@helsinki.fi.
16 Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi.
17 iCAN Digital Precision Medicine Flagship, Helsinki, Finland. satu.mustjoki@helsinki.fi.
# Contributed equally.