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Laura Campisi 1, Shahab Chizari 2,3, Jessica S Y Ho 4, Anastasia Gromova 5,6,7,8, Frederick J Arnold 5,6,7,8, Lorena Mosca 9, Xueyan Mei 10, Yesai Fstkchyan 4, Denis Torre 11,12,13, Cindy Beharry 4, Marta Garcia-Forn 14,15,16,17, Miguel Jiménez-Alcázar 18, Vladislav A Korobeynikov 19, Jack Prazich 2,3, Zahi A Fayad 10, Marcus M Seldin 20, Silvia De Rubeis 14,15,16,17, Craig L Bennett 5,6,7,8, Lyle W Ostrow 21, Christian Lunetta 22,23, Massimo Squatrito 18, Minji Byun 24, Neil A Shneider 25, Ning Jiang 2,3, Albert R La Spada 26,27,28,29, Ivan Marazzi 30,31,32; 1 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. laura.campisi@mssm.edu. 2 Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. 3 Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA. 4 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5 Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. 6 Department of Neurology, University of California, Irvine, Irvine, CA, USA. 7 Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA. 8 UCI Institute for Neurotherapeutics, University of California, Irvine, Irvine, CA, USA. 9 Medical Genetics Unit, Department of Laboratory Medicine, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy. 10 BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 11 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 12 Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 13 Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 14 Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 15 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 16 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 17 Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 18 Seve Ballesteros Foundation Brain Tumor Group, Molecular Oncology Program, Spanish National Cancer Research Centre, Madrid, Spain. 19 Department of Pathology and Cell Biology, Columbia University, New York, NY, USA. 20 Department of Biological Chemistry, Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA. 21 Neuromuscular Division of the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 22 NEMO Clinical Center, Fondazione Serena Onlus, Milan, Italy. 23 Neurorehabilitation Department, Istituti Clinici Scientifici Maugeri, IRCCS, Milan, Italy. 24 Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 25 Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, USA. 26 Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu. 27 Department of Neurology, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu. 28 Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu. 29 UCI Institute for Neurotherapeutics, University of California, Irvine, Irvine, CA, USA. alaspada@hs.uci.edu. 30 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu. 31 Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu. 32 Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ivan.marazzi@mssm.edu.