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TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL

Kirsch IR, et al.
Science Translational Medicine
August 2022
Authors and Affiliates
Ilan R Kirsch #,1, Rei Watanabe #,2, John T O'Malley 2, David W Williamson 1, Laura-Louise Scott 2, Christopher P Elco 3, Jessica E Teague 2, Ahmed Gehad 2, Elizabeth L Lowry 2, Nicole R LeBoeuf 2,4, James G Krueger 5, Harlan S Robins 1, Thomas S Kupper 2,4, Rachael A Clark 2,4; 1 Adaptive Biotechnologies, Seattle, WA, USA. 2 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 3 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 4 Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA. 5 Department of Dermatology, Rockefeller University, New York, NY, USA. # Contributed equally.

Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice

Jaini R, et al.
August 2022
Authors and Affiliates
Ritika Jaini 1,2,3, Matthew G Loya 1, Alexander T King 1, Stetson Thacker 1,2, Nicholas B Sarn 1,4, Qi Yu 1, George R Stark 5,2,4, Charis Eng 1,2,4,3; 1 Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. 2 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. 3 Germline High Risk Focus Group, CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. 4 Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. 5 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Genesis of the αβ T-cell receptor

Dupic T, et al.
August 2022
Authors and Affiliates
Thomas Dupic 1,2, Quentin Marcou 2, Aleksandra M Walczak 2, Thierry Mora 2; 1 Laboratoire de physique théorique et hautes énergies, CNRS and Sorbonne Université, 4 Place Jussieu, 75005 Paris, France. 2 Laboratoire de physique de l'ENS, CNRS, Sorbonne Université, and École normale supérieure (PSL), 24 rue Lhomond, 75005 Paris, France.

CTL Clonotypes with Higher TCR Affinity Have Better Ability to Reduce the HIV Latent Reservoir

Lima NS, et al.
Journal of Immunology
August 2022
Authors and Affiliates
Noemia S Lima 1,2,3, Hiroshi Takata 1,2,4, Szu-Han Huang 5,6, Alexander Haregot 1,2, Julie Mitchell 1,2,4, Stephen Blackmore 1,2, Ayanna Garland 1,2, Aaron Sy 1,2, Pearline Cartwright 7, Jean-Pierre Routy 8, Nelson L Michael 1, Victor Appay 9,10, R Brad Jones 5,6, Lydie Trautmann 11,2,4; 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910. 2 Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817. 3 Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814. 4 Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006. 5 Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY 10021. 6 Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037. 7 Vaccine and Gene Therapy Institute-Florida, Port St. Lucie, FL 34987. 8 Division of Hematology and Chronic Viral Illness Service, McGill University, Montreal, Quebec H3A 0G4, Canada. 9 Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Université, INSERM, Paris 75005, France; and. 10 International Research Center of Medical Sciences, Kumamoto University, Kumamoto 860-8555, Japan. 11 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910; trautmly@ohsu.edu.

Comprehensive mapping of immune perturbations associated with severe COVID-19

Kuri-Cervantes L, et al.
Science Immunology
August 2022
Authors and Affiliates
Leticia Kuri-Cervantes #,1,2, M Betina Pampena #,1,2, Wenzhao Meng 3, Aaron M Rosenfeld 3, Caroline A G Ittner 4, Ariel R Weisman 4, Roseline S Agyekum 4, Divij Mathew 1,5, Amy E Baxter 1,5, Laura A Vella 2,6, Oliva Kuthuru 2,5, Sokratis A Apostolidis 2,5,7, Luanne Bershaw 2,5, Jeanette Dougherty 2,5, Allison R Greenplate 2,5, Ajinkya Pattekar 2,8, Justin Kim 2,5, Nicholas Han 2,5, Sigrid Gouma 1,2, Madison E Weirick 1,2, Claudia P Arevalo 1,2, Marcus J Bolton 1,2, Eileen C Goodwin 1,2, Elizabeth M Anderson 1,2, Scott E Hensley 1,2, Tiffanie K Jones 4, Nilam S Mangalmurti 2,4, Eline T Luning Prak 3, E John Wherry 9,5,10, Nuala J Meyer 11, Michael R Betts 12,2; 1 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 2 Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 3 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA19104, USA. 4 Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. 5 Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. 6 Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA. 7 Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. 8 Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. 9 Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu. 10 Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. 11 Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu. 12 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu. # Contributed equally.

Tyrosine kinase inhibition alters intratumoral CD8+ T-cell subtype composition and activity

Tieniber AD, et al.
Cancer Immunology Research
August 2022
Authors and Affiliates
Andrew D Tieniber 1, Andrew N Hanna 1, Benjamin D Medina 2, Gerardo A Vitiello 3, Mark S Etherington 4, Mengyuan Liu 5, Kevin J Do 6, Ferdinand Rossi 7, Ronald P DeMatteo 4; 1 University of Pennsylvania, Philadelphia, PA, United States. 2 Memorial Sloan Kettering Cancer Center, New York, United States. 3 Memorial Sloan Kettering Cancer Center, New York, NY, United States. 4 Hospital of the University of Pennsylvania, Philadelphia, PA, United States. 5 Weill Cornell Medicine, New York, NY, United States. 6 University of Pennsylvania, Philadelphia, Pennsylvania, United States. 7 Hospital of the University of Pennsylvania, Philadelphia, United States.

Combination anti-HIV antibodies provide sustained virological suppression

Sneller MS, et al.
Nature
August 2022
Authors and Affiliates
Michael C Sneller #,1, Jana Blazkova #,1, J Shawn Justement 1, Victoria Shi 1, Brooke D Kennedy 1, Kathleen Gittens 2, Jekaterina Tolstenko 1, Genevieve McCormack 1, Emily J Whitehead 1, Rachel F Schneck 1, Michael A Proschan 3, Erika Benko 4, Colin Kovacs 4, Cihan Oguz 5,6, Michael S Seaman 7, Marina Caskey 8, Michel C Nussenzweig 8,9, Anthony S Fauci 1, Susan Moir #,1, Tae-Wook Chun #,10; 1 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. 2 Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD, USA. 3 Biostatistics Research Branch, NIAID, NIH, Bethesda, MD, USA. 4 Maple Leaf Medical Clinic, Toronto, Ontario, Canada. 5 NIAID Collaborative Bioinformatics Resource, NIAID, NIH, Bethesda, MD, USA. 6 Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. 7 Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 8 Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA. 9 Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. 10 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. twchun@nih.gov. # Contributed equally.

Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet + B cells

Csomos K, et al.
Nature Immunology
August 2022
Authors and Affiliates
Krisztian Csomos 1, Boglarka Ujhazi 2, Peter Blazso 2,3, Jose L Herrera 4,5, Christopher M Tipton 6, Tomoki Kawai 7, Sumai Gordon 2, Maryssa Ellison 2, Kevin Wu 2, Matthew Stowell 2, Lauren Haynes 2, Rachel Cruz 2, Bence Zakota 2, Johnny Nguyen 8, Michelle Altrich 9, Christoph B Geier 10, Svetlana Sharapova 11, Joseph F Dasso 2, Jennifer W Leiding 2, Grace Smith 12, Waleed Al-Herz 13, Mayra de Barros Dorna 14, Olajumoke Fadugba 15, Eva Fronkova 16, Veronika Kanderova 16, Michael Svaton 16, Sarah E Henrickson 17,18, Joseph D Hernandez 19, Taco Kuijpers 20, Snezhina Mihailova Kandilarova 21, Elizaveta Naumova 21, Tomas Milota 22, Anna Sediva 22, Despina Moshous 23,24,25, Benedicte Neven 23,24,26, Tara Saco 27, Ravishankar Sargur 28, Sinisa Savic 29,30, John Sleasman 31, Gauri Sunkersett 32, Brant R Ward 33, Masanobu Komatsu 4,5, Stefania Pittaluga 12, Attila Kumanovics 34, Manish J Butte 35, Michael P Cancro 36, Shiv Pillai 37, Eric Meffre 38,39, Luigi D Notarangelo 7, Jolan E Walter 40,41; 1 Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. kcsomos@usf.edu. 2 Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. 3 Department of Pediatrics, University of Szeged, Szeged, Hungary. 4 Cancer and Blood Disorders Institute and Department of Surgery, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. 5 Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Department of Medicine, Division of Rheumatology, Emory University, Atlanta, GA, USA. 7 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. 8 Department of Pathology & Laboratory Medicine, Johns Hopkins All Children's Hospital, St Petersburg, FL, USA. 9 Eurofins Viracor Laboratories, Lee Summit's, MO, USA. 10 Immunology Outpatient Clinic, Vienna, Austria. 11 Belarusian Research Center for Pediatric Oncology, Minsk, Belarus. 12 Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 13 Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait. 14 Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil. 15 Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 16 Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic. 17 Allergy Immunology Division, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. 18 Institute for Immunology, the University of Pennsylvania, Philadelphia, PA, USA. 19 Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, CA, USA. 20 Deptartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands. 21 Department of Clinical Immunology, University Hospital Alexandrovska, Medical University, Sofia, Bulgaria. 22 Department of Immunology, Second Faculty of Medicine Charles University and University Hospital Motol, Prague, Czech Republic. 23 Université de Paris, Paris, France. 24 Pediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades Université Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. 25 Laboratory of Genome Dynamics in the Immune System, INSERM UMR1163, Institut Imagine, Paris, France. 26 Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR1163, Institut Imagine, Paris, France. 27 Windom Allergy, Asthma and Sinus, Sarasota, FL, USA. 28 Department of Immunology and Allergy, Sheffield Teaching Hospitals, Sheffield, UK. 29 Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, UK. 30 National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK. 31 Division of Allergy, Immunology and Pulmonary Medicine, Duke University School of Medicine, Durham, NC, USA. 32 Cancer and Blood Disorder Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. 33 Division of Allergy and Immunology, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, USA. 34 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 35 Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics and Jeffrey Modell Diagnostic and Research Center, University of California, Los Angeles, Los Angeles, CA, USA. 36 Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 37 Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of technology and Harvard University, Cambridge, MA, USA. 38 Department of Immunobiology, Yale University, New Haven, CT, USA. 39 Section of Rheumatology, Allergy and Clinical Immunology, Yale School of Medicine, New Haven, CT, USA. 40 Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. jolanwalter@usf.edu. 41 Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA, USA. jolanwalter@usf.edu.

A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Wu Y, et al.
Nature Cancer
August 2022
Authors and Affiliates
Yin Wu #1,2,3,4, Dhruva Biswas #1,2,5, Ieva Usaite 1, Mihaela Angelova 2, Stefan Boeing 6, Takahiro Karasaki 1,2, Selvaraju Veeriah 1, Justyna Czyzewska-Khan 1, Cienne Morton 3, Magdalene Joseph 3,4, Sonya Hessey 1,7, James Reading 1,8, Andrew Georgiou 1,8, Maise Al-Bakir 2, TRACERx Consortium, Nicholas McGranahan 1,9, Mariam Jamal-Hanjani 1,7, Allan Hackshaw 10, Sergio A. Quezada 1,8, Adrian C. Hayday 3,4, and Charles Swanton 1,2; 1 Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. 2 Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. 3 Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King’s College London, London, UK. 4 Immunosurveillance Laboratory, The Francis Crick Institute, London, UK. 5 Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK. 6 Bioinformatics & Biostatistics and Software Development & Machine Learning Team, The Francis Crick Institute, London, UK. 7 Cancer Metastasis Lab, University College London Cancer Institute, London, UK. 8 Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK. 9 Cancer Genome Evolution Research Group, University College London Cancer Institute, London, UK. 10 Cancer Research UK & University College London Cancer Trials Centre, University College London, London, UK. # These authors contributed equally

T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma

Wang X, et al.
Journal for ImmunoTherapy of Cancer
August 2022
Authors and Affiliates
Xuefeng Wang 1, Jameel Muzaffar 2, Kedar Kirtane 2, Feifei Song 2, Matthew Johnson 2, Michael J Schell 1, Jiannong Li 1, Sean J Yoder 3, Jose R Conejo-Garcia 4, Jose A Guevara-Patino 4, Marcelo Bonomi 5, Priyanka Bhateja 5, James W Rocco 6, Conor E Steuer 7, Nabil F Saba 7, Christine H Chung 8; 1 Department of Biostatistics and Bioinformatics, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA. 2 Department of Head and Neck-Endocrine Oncology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA. 3 Department of Molecular Genomics Core, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA. 4 Department of Immunology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA. 5 Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. 6 Department of Otolaryngology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. 7 Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA. 8 Department of Head and Neck-Endocrine Oncology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA Christine.chung@moffitt.org.