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Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma

Ravindranathan S, et al.
November 2022
Authors and Affiliates
Sruthi Ravindranathan 1,2, Tenzin Passang 3,4, Jian-Ming Li 3,4, Shuhua Wang 3,4, Rohan Dhamsania 3,4, Michael Brandon Ware 3,4, Mohammad Y Zaidi 3,4, Jingru Zhu 3,4, Maria Cardenas 5, Yuan Liu 4,6, Sanjeev Gumber 7,8, Brian Robinson 7, Anish Sen-Majumdar 9, Hanwen Zhang 3, Shanmuganathan Chandrakasan 10, Haydn Kissick 4,5,11, Alan B Frey 9, Susan N Thomas 12,13, Bassel F El-Rayes 3,4, Gregory B Lesinski 3,4, Edmund K Waller 14,15; 1 Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA. 2 Winship Cancer Institute, Emory University, Atlanta, GA, USA. 3 Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA. 4 Winship Cancer Institute, Emory University, Atlanta, GA, USA. 5 Department of Urology, Emory University School of Medicine, Atlanta, GA, USA. 6 Rollins School of Public Health, Emory University, Atlanta, GA, USA. 7 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA. 8 Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. 9 Cambium Oncology LLC, Atlanta, GA, USA. 10 Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, USA. 11 Emory Vaccine Centre, Emory University, Atlanta, GA, USA. 12 Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. 13 Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. 14 Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA. 15 Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster

Laing KJ, et al.
Nature Communications
November 2022
Authors and Affiliates
Kerry J Laing 1, Werner J D Ouwendijk 2, Victoria L Campbell 3, Christopher L McClurkan 3, Shahin Mortazavi 3, Michael Elder Waters 3, Maxwell P Krist 3, Richard Tu 3, Nhi Nguyen 3, Krithi Basu 3, Congrong Miao 4, D Scott Schmid 4, Christine Johnston 3,5, Georges M G M Verjans 2, David M Koelle 3,5,6,7,8; 1 Department of Medicine, University of Washington, Seattle, WA, USA. laingk@uw.edu. 2 HerpeslabNL of the Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. 3 Department of Medicine, University of Washington, Seattle, WA, USA. 4 Centers for Disease Control and Prevention, Division of Viral Diseases, Atlanta, GA, USA. 5 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. 6 Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. 7 Department of Global Health, University of Washington, Seattle, WA, USA. 8 Department of Translational Research, Benaroya Research Institute, Seattle, WA, USA.

A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Darragh LB, et al.
Nature Cancer
November 2022
Authors and Affiliates
Laurel B Darragh 1,2, Michael M Knitz 1, Junxiao Hu 3, Eric T Clambey 4, Jennifer Backus 1, Andrew Dumit 1, Von Samedi 5, Andrew Bubak 6, Casey Greene 3,7, Timothy Waxweiler 1, Sanjana Mehrotra 5, Shilpa Bhatia 1, Jacob Gadwa 1, Thomas Bickett 1, Miles Piper 1, Kareem Fakhoury 1, Arthur Liu 8, Joshua Petit 8, Daniel Bowles 9, Ashesh Thaker 10, Kimberly Atiyeh 11, Julie Goddard 12, Robert Hoyer 9, Adrie Van Bokhoven 5, Kimberly Jordan 2, Antonio Jimeno 9, Angelo D'Alessandro 7, David Raben 1, Jessica D McDermott 9, Sana D Karam 13,14; 1 Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 2 Department of Immunology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 3 Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA. 4 Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 5 Department of Pathology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 6 Department of Neurology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 7 Department of Biochemistry and Molecular Genetics, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 8 Department of Radiation Oncology, University of Colorado, Poudre Valley Hospital, Fort Collins, CO, USA. 9 Division of Medical Oncology, University of Colorado School of Medicine, Aurora, CO, USA. 10 Department of Radiology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 11 Department of Otolaryngology Head and Neck Surgery, University of Colorado, Memorial South Hospital, Colorado Springs, CO, USA. 12 Department of Otolaryngology Head and Neck Surgery, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. 13 Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. sana.karam@cuanschutz.edu. 14 Department of Immunology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. sana.karam@cuanschutz.edu.

Urinary T cells are detected in patients with immune checkpoint inhibitor-associated immune nephritis that are clonotypically identical to kidney T cell infiltrates

Singh S, et al.
OncoImmunology
November 2022
Authors and Affiliates
Shailbala Singh 1, Leticia C Clemente 2, Edwin R Parra 2, Amanda Tchakarov 3, Chao Yang 4, Yisheng Li 4, James P Long 4, Cassian Yee 1,5, Jamie S Lin 6; 1 Department of Melanoma Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. 2 Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. 3 Department of Pathology and Laboratory Medicine, University of Texas Health Science Center McGovern Medical School, Houston, TX, USA. 4 Department of Biostatistics, Division of Basic Sciences, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. 5 Department of Immunology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. 6 Section of Nephrology, Division of Internal Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.

BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes

Takahashi H, et al.
Science Advances
November 2022
Authors and Affiliates
Hiroyuki Takahashi 1, Willem M Kühtreiber 1, Ryan C Keefe 1, Amanda H Lee 1, Anna Aristarkhova 1, Hans F Dias 1, Nathan Ng 1, Kacie J Nelson 1, Stephanie Bien 2, Danielle Scheffey 2, Denise L Faustman 1; 1 Immunobiology Department, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. 2 Adaptive Biotechnologies, Seattle, WA 98109, USA.

Minimal residual disease in patients with diffuse large B-cell lymphoma undergoing autologous stem cell transplantation.

Merryman RW, et al.
Blood Advances
November 2022
Authors and Affiliates
Reid W. Merryman1, Robert A. Redd2, Eleanor Taranto3, Gulrayz Ahmed4, Erin Jeter1, Kristin M. McHugh1 4 , Jennifer R. Brown1, Jennifer L. Crombie1, Matthew S. Davids1, David C. Fisher1, Arnold S. Freedman1 5 , Eric Jacobsen1, Caron A. Jacobson1, Austin I. Kim1, Ann S. LaCasce1, Samuel Y. Ng1, Oreofe O. Odejide1 6 , Erin M. Parry1, Heather Jacene5, Hyesun Park5, Parastoo B. Dahi6, Yago Nieto7, Robin M. Joyce8, Yi-Bin Chen9 7 , Margaret A. Shipp1, Alex F. Herrera10*, and Philippe Armand1 8 * 1 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 2 Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 3 Department of Medicine, Brigham and Women's Hospital, Boston, MA 4 Medical College of Wisconsin, Milwaukee, WI 5 Department of Imaging/Radiology, Dana-Farber Cancer Institute/Brigham and Women’s Hospital, Boston, MA 6 Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan-Kettering Cancer Center, New York, NY 7 Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 8 Department of Hematologic Malignancy, Beth Israel Deaconess Medical Center, Boston, MA 9 Bone Marrow Transplantation Program, Massachusetts General Hospital, Boston, MA 10 Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA *These authors contributed equally to this work.

Anti-CD19 CAR T cells in combination with ibrutinib for the treatment of chronic lymphocytic leukemia.

Gill S, et al.
Blood Advances
November 2022
Authors and Affiliates
Saar Gill,1,2 Vanessa Vides,3 Noelle V. Frey,1 Elizabeth O. Hexner,1,2 Susan Metzger,2 Megan O’Brien,2 Wei-Ting Hwang,4 Jennifer L. Brogdon,5 Megan M. Davis,2 Joseph A. Fraietta,2,6,9 Avery L. Gaymon,2 Whitney L. Gladney,2 Simon F. Lacey,2 Anne Lamontagne,2 Anthony R. Mato,1 Marcela V. Maus,7 J. Joseph Melenhorst,2,6,9 Edward Pequignot,2 Marco Ruella,1,2 Maksim Shestov,1,2 John C. Byrd,8 Stephen J. Schuster,1 Donald L. Siegel,2,6 Bruce L. Levine,2,6 Carl H. June,2,6,9 and David L. Porter1 1Cell Therapy and Transplant Program, Division of Hematology-Oncology and Abramson Cancer Center and 2Center for Cellular Immunotherapies, University of Pennsylvania,Philadelphia, PA; 3Pennsylvania State University College of Medicine, Hershey, PA; 4Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania,Philadelphia, PA; 5Novartis Institutes for Biomedical Research, Cambridge, MA; 6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia,PA; 7Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA; 8Division of Hematology, The Ohio State University, Columbus, OH; and 9Parker Institute for Cancer Immunotherapy

Hyper-CVAD and sequential blinatumomab for newly diagnosed Philadelphia chromosome-negative B-cell acute lymphocytic leukaemia: a single-arm, single-centre, phase 2 trial.

Jabbour E, et al.
Lancet Haematology
October 2022
Authors and Affiliates
Elias Jabbour*, Nicholas J Short*, Nitin Jain, Philip A Thompson, Tapan M Kadia, Alessandra Ferrajoli, Xuelin Huang, Musa Yilmaz, Yesid Alvarado, Keyur P Patel, Guillermo Garcia-Manero, Walid Macaron, Rebecca Garris, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian *These authors contributed equally Department of Leukemia (Prof E Jabbour MD, N J Short MD, N Jain MD, P A Thompson MBBS, Prof T M Kadia MD, Prof A Ferrajoli MD, M Yilmaz MD, Y Alvarado MD, Prof G Garcia-Manero MD, W Macaron MD, R Garris MS, Prof M Konopleva MD PhD, Prof F Ravandi MD, Prof H Kantarjian MD), Department of Biostatistics (Prof X Huang PhD), and Department of Hematopathology (K P Patel MD), The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Temporal development of T cell receptor repertoires during childhood in health and disease

Mitchell AM, et al.
JCI Insight
September 2022
Authors and Affiliates
Angela M Mitchell 1, Erin E Baschal 1, Kristen A McDaniel 1, Kimber M Simmons 1, Laura Pyle 2, Kathleen Waugh 1, Andrea K Steck 1, Liping Yu 1, Peter A Gottlieb 1, Marian J Rewers 1, Maki Nakayama 1, Aaron W Michels 1; 1 Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, United States of America. 2 Department of Biostatistics and Informatics, University of Colorado School of Pubic Health, Aurora, United States of America.

Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection

Postoak JL, et al.
Journal of Experimental Medicine
September 2022
Authors and Affiliates
J Luke Postoak 1, Wenqiang Song 1, Guan Yang 1, Xingyi Guo 2, Shiyun Xiao 3, Cherie E Saffold 1, Jianhua Zhang 4,5, Sebastian Joyce 1,6, Nancy R Manley 3, Lan Wu 1, Luc Van Kaer 1; 1 Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN. 2 Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN. 3 Department of Genetics, University of Georgia, Athens, GA. 4 Department of Pathology, University of Alabama at Birmingham, Birmingham, AL. 5 Birmingham Veterans Affairs Medical Center, Birmingham, AL. 6 Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN.
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