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Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML
Fujii S, et al.
Molecular Therapy — Oncolytics
December 2022
Authors and Affiliates
Shin-ichiro Fujii 1,2,10, Toyotaka Kawamata 3,10, Kanako Shimizu 1,10, Jun Nakabayashi 4, Satoru Yamasaki 1, Tomonori Iyoda 1, Jun Shinga 1, Hiroshi Nakazato 1, An Sanpei 1, Masami Kawamura 1, Shogo Ueda 1, Jan Dörrie 5, Svetlana Mojsov 6, Madhav V. Dhodapkar 7, Michihiro Hidaka 8, Masanori Nojima 9, Fumitaka Nagamura 9, Shigemi Yoshida 2, Toshio Goto 2, and Arinobu Tojo 3;
1 Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Science (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan
2 Program for Drug Discovery and Medical Technology Platforms, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan
3 Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo (IMSUT): Minato-ku, Tokyo, Japan
4 Department of Mathematics, Tokyo Medical and Dental University, Ichikawa, Chiba, Japan
5 Department of Dermatology, Universitätsklinikum Erlangen, Erlangen, Germany
6 The Rockefeller University, New York, NY, USA
7Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, GA, USA
8Department of Hematology/Oncology, National Hospital Organization Kumamoto Medical Center, Clinical Laboratory: Kumamoto, Kumamoto, Japan
9Center for Translational Research, The Institute of Medical Science, The University of Tokyo (IMSUT), Minato-ku, Tokyo, Japan
Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection
Win TS, et al.
JCI
November 2022
Authors and Affiliates
Thet Su Win 1,2, William J Crisler 1, Beatrice Dyring-Andersen 1, Rachel Lopdrup 2, Jessica E Teague 1, Qian Zhan 1, Victor Barrera 3, Shannan Ho Sui 3, Sotirios Tasigiorgos 2, Naoka Murakami 4, Anil Chandraker 4, Stefan G Tullius 5, Bohdan Pomahac 2, Leonardo V Riella 4, Rachael A Clark 1;
1 Department of Dermatology and.
2 Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
3 Bioinformatics Core, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
4 Schuster Transplantation Research Center and.
5 Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Cross-reactivity of SARS-CoV-2- and influenza A-specific T cells in individuals exposed to SARS-CoV-2
Chaisawangwong W, et al.
JCI Insight
November 2022
Authors and Affiliates
Worarat Chaisawangwong 1, Hanzhi Wang 2, Theodore Kouo 3, Sebastian F Salathe 1, Ariel Isser 4,5, Joan Glick Bieler 1, Maya L Zhang 2, Natalie K Livingston 4, Shuyi Li 1, Joseph J Horowitz 6, Ron E Samet 7, Israel Zyskind 8, Avi Z Rosenberg 1, Jonathan P Schneck 1,4,5,9,10;
1 Department of Pathology, School of Medicine.
2 Department of Biomedical Engineering, Whiting School of Engineering.
3 Department of Pediatrics, Division of Emergency Medicine.
4 Department of Biomedical Engineering, School of Medicine, and.
5 Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
6 ExpressCare Urgent Care, Bel Air, Maryland, USA.
7 Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
8 Department of Pediatrics, NYU Langone Medical Center, New York, New York, USA; Maimonides Medical Center, New York, New York, USA.
9 Institute for Nanobiotechnology and.
10 Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir
Benner SE, et al.
JCI Insight
November 2022
Authors and Affiliates
Sarah E Benner 1, Yolanda Eby 1, Xianming Zhu 1, Reinaldo E Fernandez 2, Eshan U Patel 1,3, Jessica E Ruff 1, Feben Habtehyimer 2, Haley A Schmidt 1, Charles S Kirby 1, Sarah Hussain 2, Darin Ostrander 2, Niraj M Desai 4, Sander Florman 5, Meenakshi M Rana 6, Rachel Friedman-Moraco 7, Marcus R Pereira 8, Shikha Mehta 9, Peter Stock 10, Alexander Gilbert 11, Michele I Morris 12, Valentina Stosor 13, Sapna A Mehta 14, Catherine B Small 15, Karthik Ranganna 16, Carlos Aq Santos 17, Saima Aslam 18, Jennifer Husson 19, Maricar Malinis 20, Nahel Elias 21, Emily A Blumberg 22, Brianna L Doby 23,24, Allan B Massie 14, Melissa L Smith 25, Jonah Odim 26, Thomas C Quinn 2,26, Gregory M Laird 27, Robert F Siliciano 2, Dorry L Segev 4,14, Andrew D Redd 2,26, Christine M Durand 2, Aaron Ar Tobian 1;
1 Department of Pathology and.
2 Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
3 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
4 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
5 Recanati/Miller Transplantation Institute and.
6 Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
7 Department of Medicine, Emory University, Atlanta, Georgia, USA.
8 Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
9 Department of Medicine, University of Alabama Heersink School of Medicine, Birmingham, Alabama, USA.
10 Department of Surgery, University of California, San Francisco, San Francisco, California, USA.
11 Medstar Transplant Institute, Georgetown University School of Medicine, Washington, DC, USA.
12 Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
13 Departments of Medicine and Surgery, Divisions of Infectious Diseases and Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
14 Department of Surgery, New York University Grossman School of Medicine, NYU Langone Health, New York, New York, USA.
15 Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA.
16 Department of Medicine, Drexel University, Philadelphia, Pennsylvania, USA.
17 Divison of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA.
18 Department of Medicine, University of California, San Diego, San Diego, California, USA.
19 Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
20 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
21 Department of Surgery and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
22 Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
23 Positive Rhetoric LLC, Bowling Green, Kentucky, USA.
24 Department of Public Health Sciences, College of Health, Education, and Social Transformation, New Mexico State University, Las Cruces, New Mexico, USA.
25 Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, Kentucky, USA.
26 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
27 AccelevirDx, Baltimore, Maryland, USA.
Immunogenomic profiling of lung adenocarcinoma reveals poorly differentiated tumors are associated with an immunogenic tumor microenvironment
Akhave N, et al.
Lung Cancer
November 2022
Authors and Affiliates
Neal Akhave 1, Jiexin Zhang 2, Erin Bayley 3, Meredith Frank 1, Shin-Heng Chiou 4, Carmen Behrens 5, Runzhe Chen 1, Xin Hu 6, Edwin Roger Parra 7, Won-Chul Lee 6, Stephen Swisher 3, Luisa Solis 7, Annikka Weissferdt 8, Cesar Moran 8, Neda Kalhor 8, Jianhua Zhang 6, Paul Scheet 8, Ara A Vaporciyan 3, Boris Sepesi 3, Don L Gibbons 1, John V Heymach 1, Jack J Lee 9, Ignacio I Wistuba 5, P Andrew Futreal 6, Jianjun Zhang 10, Junya Fujimoto 11, Alexandre Reuben 12;
1 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
2 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
3 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
4 Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 195 Little Albany St, New Brunswick, NJ 08901, USA.
5 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
6 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
7 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
8 Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA; Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
9 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
10 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. Electronic address: jzhang20@mdanderson.org.
11 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. Electronic address: jfujimot@mdanderson.org.
12 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
Combination Nivolumab, CD137 Agonism, and Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma
Hall MS, et al.
Clinical Cancer Research
November 2022
Authors and Affiliates
MacLean S Hall 1, John E Mullinax 1, Cheryl A Cox 1, Amy M Hall 1, Matthew S Beatty 1, Jamie Blauvelt 1, Patrick Innamarato 1, Luz Nagle 1, Holly Branthoover 1, Doris Wiener 1, Benjamin Schachner 1, Alberto J Martinez 1, Allison D Richards 1, Carolyn J Rich 1, Marjorie Colón Colón 1, Michael J Schell 1, Jamie K Teer 2, Nikhil I Khushalani 1, Jeffrey S Weber 3, James J Mule 1, Vernon K Sondak 1, Shari Pilon-Thomas 4, Amod A Sarnaik 1;
1 Moffitt Cancer Center, Tampa, FL, United States.
2 H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States.
3 NYU Langone Medical Center, New York, NY, United States.
4 H Lee Moffitt Cancer Center, Tampa, FL, United States.
Distorted TCR repertoires define multisystem inflammatory syndrome in children
Malik A, et al.
PLOS ONE
November 2022
Authors and Affiliates
Amna Malik 1, Eszter N Tóth 2, Michelle S Teng 2, Jacob Hurst 2, Eleanor Watt 3, Lauren Wise 4, Natalie Kent 4, Jack Bartram 5, Louis Grandjean 6, Margarita Dominguez-Villar 7, Stuart Adams 4, Nichola Cooper 1;
1Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom.
2Etcembly Ltd, Magdalen Centre, Robert Robinson Way, Oxford, United Kingdom.
3Molecular and Cellular Immunology Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
4SIHMDS-Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
5Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
6Paediatric Infectious Diseases, Great Ormond Street Hospital for Children, London, United Kingdom.
7Department of Infectious Diseases, Imperial College London, London, United Kingdom.
Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling
Tuovinen EA, et al.
JCI
November 2022
Authors and Affiliates
Elina A Tuovinen 1 2 3, Sakari Pöysti # 4, Firas Hamdan # 1 5 6, Kim My Le 1 3, Salla Keskitalo 7, Tanja Turunen 7, Léa Minier 1 8, Nanni Mamia 1 3, Kaarina Heiskanen 3 9, Markku Varjosalo 7, Vincenzo Cerullo 1 5 6, Juha Kere 2 10 11, Mikko R J Seppänen 1 3 12, Arno Hänninen 4, Juha Grönholm 13 14;
1Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
2Folkhälsan Research Center, Helsinki, Finland.
3Pediatric Research Center, New Children's Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.
4Department of Clinical Microbiology and Immunology, Turku University Hospital, Turku, Finland.
5Drug Research Program Helsinki (DRP), Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
6Digital Precision Cancer Medicine Flagship (iCAN), University of Helsinki, Helsinki, Finland.
7Systems Biology Research Group and Proteomics Unit, Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
8Faculty of Science and Technology, University of Lille, Lille, France.
9Children's Immunodeficiency Unit, New Children's Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.
10Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
11Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
12Rare Diseases Center and Pediatric Research Center, New Children's Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.
13Translational Immunology Research Program, University of Helsinki, Helsinki, Finland. juha.gronholm@helsinki.fi.
14Pediatric Research Center, New Children's Hospital, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland. juha.gronholm@helsinki.fi.
#Contributed equally.
Evolution and modulation of antigen-specific T cell responses in melanoma patients
Huuhtanen J, et al.
Nature Communications
November 2022
Authors and Affiliates
Jani Huuhtanen 1 2 3 4, Liang Chen 5 6, Emmi Jokinen 4, Henna Kasanen 1 2 3, Tapio Lönnberg 7 8, Anna Kreutzman 1 2 3, Katriina Peltola 3 9, Micaela Hernberg 9, Chunlin Wang 5 6, Cassian Yee 10 11, Harri Lähdesmäki 4, Mark M Davis 12 13 14, Satu Mustjoki 15 16 17 18;
1Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
2Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
3iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.
4Department of Computer Science, Aalto University, Espoo, Finland.
5Department of Immunology and Microbiology, Stanford University, Stanford, CA, USA.
6Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
7Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
8InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
9Department of Oncology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
10Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
11Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
12Department of Immunology and Microbiology, Stanford University, Stanford, CA, USA. mmdavis@stanford.edu.
13Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. mmdavis@stanford.edu.
14Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. mmdavis@stanford.edu.
15Translational Immunology Research Program, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi.
16Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. satu.mustjoki@helsinki.fi.
17iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland. satu.mustjoki@helsinki.fi.
18Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi.